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Clinical and TranslationalScience Institute / CTSIat the University of California, San Francisco
CTSI Annual Retreat 2011A Tale of Summer
S. Claiborne Johnston, MD, PhD
Associate Vice Chancellor of Research & CTSI Director
“Daddy, why does the train stop
here?”
- Teo Johnston, Age 8
Evolution of an Industry
• Start-up/building phase
– Hire
– Build basic structures
– Start slow but accelerate
1857
Investors
• European investment groups.
1850 1860 1870 1880 1890
New England 2,507 3,660 4,494 5,982 6,831
Middle States 3,202 6,705 10,964 15,872 21,536
Southern
States2,036 8,838 11,192 14,778 29,209
Western
States and
Territories
1,276 11,400 24,587 52,589 62,394
Pacific States
and
Territories
23 1,677 4,080 9,804
Totals 9,021 30,626 52,914 93,301 129,774
US Regional Miles of Railroad
Railroads in 1918
1918
Number of industry-sponsored clinical
trials
0
20
40
60
80
100
120
140
160
180
200
new amendment No cost extensions
2009
2010
# c
on
tra
cts
n = 374
n = 423
Median Cycle Time for Industry Contractsfrom internal documents complete to final award – industry clinical trials
Ca
len
da
r d
ays
0
10
20
30
40
50
60
70
80
New Amendments no cost extensions
2008
2009
2010
IRB Approval Times
2009 139 days
2010 71 days
“Daddy, why does the train stop
here?”
- Teo Johnston, Age 8
Railroads in 1918
1918
2006
Evolution of an Industry
• Start-up/building phase
– Hire
– Build basic structures
– Start slow but accelerate
• Sustainability phase
– Prepare for change; keep eyes on future
– Consider more flexible approaches
– Continue to innovate
CTSI Retreat 2011
12:45-3:00 “CTSI Idol”
3:00-3:20 Break
3:20-4:00 Defining Success
4:00-4:20 Early Stage Translation
4:20-4:40 Improving the Health of SF
4:40-5:00 Closing Discussion
5:00-6:00 Reception
