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www.crescendus.com ゥ Crescendus™ 2012-2013. All Rights Reserved. 1 Crescendus™ Crescendus™ Business Development Consulting Services Pharmaceuticals|Biotechnology|Generics|Biosimilars|Biologics| Companion Biomarkers & Diagnostics (In-Vivo/In-Vitro)

Crescendus™- Business Development for Biotech, Pharma, Generics & Diagnostics Companies

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Use Crescendus™ to assist your complex Healthcare Business Development needs in the USA. With increasing pressures from R&D productivity, Innovation, Health Outcomes, Declining Reimbursement and Patent Cliffs, it is imperative that companies strengthen their business intelligence and business development functions. The presentation highlights our expertise in the following areas- DISEASE EXPERTISE: Cancer | Alzheimers | Diabetes | Parkinsons | Heart Disease | Skin Disease | Infectious Diseases, etc. DRUG DISCOVERY & DEVELOPMENT BUSINESS DEVELOPMENT EXPERTISE: Small Molecules | Biologics | Generics | Biosimilars | Vaccines | Diagnostics | Biomarkers This presentation will be useful for the following audience: 1. CEO & CFO looking for strategic help and flexibility 2. Core Business Development & Alliances teams 3. Investors (Venture Capital and Private Equity) 4. US and Non-US Companies planning to expand their business development functions in the USA.

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Page 1: Crescendus™- Business Development for Biotech, Pharma, Generics & Diagnostics Companies

www.crescendus.com© Crescendus™ 2012-2013. All Rights Reserved.

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Crescendus™Crescendus™

Business Development Consulting ServicesPharmaceuticals|Biotechnology|Generics|Biosimilars|Biologics|Companion Biomarkers & Diagnostics (In-Vivo/In-Vitro)

Page 2: Crescendus™- Business Development for Biotech, Pharma, Generics & Diagnostics Companies

www.crescendus.com© Crescendus™ 2012-2013. All Rights Reserved.

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Crescendus™ Outline

Industry Expertise 3

Services 4-7

Select Approaches to Working with Clients 8-9

Benefits to Clients 10

Contact Information 11

Pharmaceuticals|Biotechnology|Generics|Biosimilars|Biologics|Companion Biomarkers & Diagnostics (In-Vivo/In-Vitro)

Page 3: Crescendus™- Business Development for Biotech, Pharma, Generics & Diagnostics Companies

www.crescendus.com© Crescendus™ 2012-2013. All Rights Reserved.

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Crescendus™ Industry Expertise

Cancer

Alzheimer's

Diabetes

HeartDisease

InfectiousDiseases

COPD

AsthmaArthritis

SkinDiseaseParkinsons

Parkinsons

Obesity

AnimalHealth

SmallMolecules

Biologics

Generics

Biosimilars

CompanionBiomarkers

Vaccines

Diagnostics

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www.crescendus.com© Crescendus™ 2012-2013. All Rights Reserved.

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Crescendus™Services

1. In & Out-Licensing Agreements• Upfront Payments• Co-Development/Collaboration• Co-Marketing• Manufacturing• Technology Transfer• Territory Rights across the Globe• Milestone Payments• Pre-clinical• Phase-I• Phase-II• Phase-III• Royalties (incl. tiered)• Joint Committee Management• Opt-In Rights for Future Molecules• Rights for First Refusal• Negotiations• Exclusive/ Non-Exclusive2. Valuation Analysis• rNPV• DCF• Real Options• Risk

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Crescendus™Services

3. Strategy• Build-Buy-Partner-Divest• Strategic Alliances• M&A• Minority Investment• Divestiture• Spin-off• Carve-out• Split-off• Hostile Takeovers• Appropriate Defense (e.g. Poison Pill)4. Complex Deal Structures• Revenue Sharing• Contingency Value Rights (CVR), Earnouts, Collars• Cross-border transactions• Upfront, Milestone, Royalties• Acquisition Rights• Territory Specific Contingency Clauses• Reimbursement Outcomes specific Terms• Companion Biomarker (In-vitro & In-vivoDiagnostics)-Therapeutics

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Crescendus™Services5. Supply Agreements• Manufacturing• Reagents/Molecules for R&D• Clinical Trials• Outsourcing6. Commercial Agreements• Market Size Estimations• Pricing by Territory• Revenue Sharing• Level of Effort by participating parties• Go-to-Market Approaches7. Partner/Target Identification• Target Identification• Target Contacts• Target Negotiations• Deal Structuring (Licensing, Joint Ventures, M&A,Divestitures)

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Crescendus™Services

8. Mergers & Acquisitions (M&A)• Buyer/Target Identification & Marketing• Site Visits, Initial Discussions, Coaching Teams• Due Diligence, Data Rooms• Valuation• Deal Structuring• Negotiations• Financing• Closing• Post-Merger Integration (Governance, SynergyCapture, Execution)9. Global Industry Intelligence• Deals• Business Development activities of industryleaders & your competitors• Investor activities in new ventures• Technologies available for licensing by country• Contacts• Industry events and developments• Pipeline/Portfolio Analysis

Page 8: Crescendus™- Business Development for Biotech, Pharma, Generics & Diagnostics Companies

www.crescendus.com© Crescendus™ 2012-2013. All Rights Reserved.

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Crescendus™ Select Approaches to Working with Clients

PRE-SEED STARTUPSPRIVATE EQUITY FIRMSVENTURE CAPITAL FIRMSUNIVERSITYACCELERATORS

(do not have existing BusinessDevelopment and/or ExecutiveResources)

1. Company formation services include licensing technologies from IPholder and performing wide range of services (business development& other extended list of offerings from Crescendus™ during theirstealth mode). This includes handling initial management/executiveroles within the new company (including buyout companies of privateequity firms).

2. Pricing- Hourly Rates ($250-$550/hr, depending upon taskcomplexity & expertise of personnel).

3. Duration- 6-9 months.

ESTABLISHED COMPANIES& STARTUPS

(have existing BusinessDevelopment Resources)

1. Provide business development advisory services depending upon thespecific needs of the client, and their time bandwidth and industryexpertise.

2. Pricing- Hourly Rates ($250-$550/hr, depending upon taskcomplexity & expertise of personnel).

3. Duration- 3-6 months.

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Crescendus™

1. Provide business development advisory services along with USArepresentation. This includes handling all aspects of client’sbusiness development in USA via our local office.

2. Pricing- Hourly Rates ($250-$550/hr, depending upon taskcomplexity & expertise of personnel).

3. Duration- 6-12 months.

FOREIGN COMPANIES

(Seeking access to USBusiness DevelopmentOpportunities)

Select Approaches to Working with Clients

Page 10: Crescendus™- Business Development for Biotech, Pharma, Generics & Diagnostics Companies

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Crescendus™ Benefits to Clients

1. Strategic Flexibility• Companies can continue their operations without worrying about hiring full time employees &incurring direct/in-direct costs on their books• This will be important in 2013 and beyond when global economic conditions are expected to eitherslow or deteriorate2. On-Demand Industry Expertise• Ready access to industry trends, intelligence & expert resources• Especially useful while negotiating complex deals• Scouting for new growth opportunities (across the globe)3. Company Formation Options• IP holders can readily form companies using Crescendus™ expertise & run them in stealth mode• Acts as a strategic bridge before the company can hire its management team• Preserve stock ownership4. USA Representation for Foreign Companies• Low risk approach to enter the US market and explore opportunities without incurring real estateand personnel costs• Ready access to a local partner who can represent their interests in complex deal scouting, clientvisits, deal structuring/negotiations and closing

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www.crescendus.com© Crescendus™ 2012-2013. All Rights Reserved.

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Crescendus™

Email:[email protected]

Web:www.crescendus.com

Phone:1-(865)-332-0942

(Non-US companies- Dial 001 prior tothe 865 area code)

Contact Information