REBRANDING HEMP FOR THE NEUTRACEUTICAL MARKET

CANTERPENE AS A HEALTHSPAN EXTENSION SUPPLEMENT

Lifespan Pharma Inc.

Morris Johnson, CTO, Founder

Terry Grossman, M.D., Medical Director

Silas Kanning,

Co-founder

REBRANDING HEMP AS CANTERPENE MAKES SENSE FOR THE NATURAL HEALTH PRODUCT/ DSHEA FOOD SUPPLEMENT MARKETS

35 YEARS AGO RAPESEED EXPERIENCED THE SAME PROBLEMS AFFECTING HEMP TODAYGrowers needed to rebrand something that was associated with a machine oil regarded as too toxic for humans to consume

Low Erucic Acid Rapeseed (LEAR)?

“CANadian source of OLeic Acid” became CANOLA

It was promoted as a safe, nutritious, multi-purpose human and animal food ingredient

Hemp is undergoing a similar identity crisisHemp is undergoing a similar identity crisis i in the n the minds of many todayminds of many today

When you Google “hemp” you get a large When you Google “hemp” you get a large number of “POT” hitsnumber of “POT” hits

Purveyors of recreational and medicinal Purveyors of recreational and medicinal marijuana use “hemp” indiscriminately when marijuana use “hemp” indiscriminately when speaking about marijuanaspeaking about marijuana

SOME CANADIAN HEMP PRODUCTS SOME CANADIAN HEMP PRODUCTS ASSOCIATE HEMP WITH MARIJUANAASSOCIATE HEMP WITH MARIJUANA

ASSOCIATING HEMP WITH MARIJUANA IS CREATING CONSUMER CONFUSION

• Solutions:• Litigate?

• Regulate?

• Educate?

• Ignore?

AFTER MUCH CONSIDERATION WE AFTER MUCH CONSIDERATION WE CONCLUDED NONE OF THE ABOVE CONCLUDED NONE OF THE ABOVE SOLUTIONS ARE PRACTICAL OR COST SOLUTIONS ARE PRACTICAL OR COST EFFECTIVEEFFECTIVE

Some hemp manufacturers Some hemp manufacturers want to capitalize on the science want to capitalize on the science which has popularized the which has popularized the term “Medical Marijuana” term “Medical Marijuana”

The best solution: The best solution: REBRANDING REBRANDING

REBRAND CANADIAN HEMP AS REBRAND CANADIAN HEMP AS CANTERPENECANTERPENE

We link Canadian Hemp with the message

“Extend Health-span and Life-span naturally with cannabis chemistry

WE HAVE PATENTED CANTERPENE WE HAVE PATENTED CANTERPENE AS A PROPRIETARY FORMULATION AS A PROPRIETARY FORMULATION OF MILLED HEMPSEEDOF MILLED HEMPSEED

AGING CAN BE BRUTAL

IT IS POSSIBLE TO GROW OLDER WITHOUT AGING AT ANY AGE

60 yrs old 80 yrs old

ANTIAGING IS AN ENORMOUS MARKET

76 million baby boomers in the US

6 million “boomies” in Canada

Boomers now 48 – 64 and have begun to experience the “aging process” firsthand

This generation has redefined each stage of their lives and is currently redefining aging

BOOMERS REGARD AGING IS A DISEASE …

… THAT AFFECTS EVERYONE

… AND IS 100 PERCENT FATAL

THIS IS THE NEW VIEW OF AGING

Bob Delmonteque, age 84

THE TWO PILLARS OF HEALTH

Prevention EarlyDetection

CANTERPENE CAN HELP AS A PREVENTIVE ANTIAGING STRATEGY

Science has linked numerous Cannabis Science has linked numerous Cannabis compounds found in Canterpene with compounds found in Canterpene with beneficial effects on the diseases resulting beneficial effects on the diseases resulting from “normal” agingfrom “normal” aging

Canterpene captures much that other Canterpene captures much that other conventional hemp supplements have conventional hemp supplements have ignoredignored

Can Canterpene work as a lifespan Can Canterpene work as a lifespan enhancement tool?enhancement tool?

  

THE MEDICAL BENEFITS

CANTERPENE

NUMEROUS BIOCHEMICAL BENEFITS OF CANNABINOIDS IN HEMP

SOME DISEASES/CONDITIONS ASSOCIATED WITH AGING

Oxidative stress

Arthritis

Central nervous system degeneration

Parkinson’s

Alzheimer’s

Cannabidiol (CBD) the major cannabinoid in hemp has been shown to be of benefit in each of these and many other conditions

OXIDATIVE STRESSCBD treatment significantly reduced oxidative stress; decreased the levels of tumor necrosis factor, vascular endothelial growth factor, and intercellular adhesion molecule-1; and prevented retinal cell death and vascular hyperpermeability in the diabetic retina. Consistent with these effects, CBD treatment also significantly inhibited p38 MAP kinase in the diabetic retina. These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals.

EL Remessey AB et al. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol. 2006 Jan;168(1):235-44.

ARTHRITIS

These potentially anti-inflammatory properties of CBD, together with the lack of psychotropic effect and low toxicity prompted us to test the potential of CBD as a therapeutic agent in collagen-induced arthritis (CIA).

RESULTS: “We report that CBD has a beneficial therapeutic action on established CIA.”

Malfait AM et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9561-6.

PARKINSON’S DISEASEEvidence suggests that cannabinoids may prove useful in Parkinson's disease by inhibiting the excitotoxic neurotransmitter glutamate and counteracting oxidative damage to dopaminergic neurons

Croxford JL. Therapeutic potential of cannabinoids in CNS disease. CNS Drugs. 2003;17(3):179-202.

It seems that cannabinoids could delay or even stop progressive degeneration of brain dopaminergic systems, a process for which there is presently no prevention. In combination with currently used drugs, cannabinoids might represent, qualitatively, a new approach to the treatment of PD, making it more effective.

Sevcik J, Masek K Potential role of cannabinoids in Parkinson's disease DRUG AGING 16 (6): 391-395 JUN 2000

ALZHEIMER’S DISEASEMemory loss, the first and primary symptom of Alzheimer’s disease, can be slowed down significantly in mice by cannabidiol.

In a study at the Cajal Institute in Madrid, Spain, mice were injected with a molecule found in the brain of humans suffering from Alzheimer’s disease, and then treated for one week with cannabidiol.

Those mice injected with cannabidiol successfully performed the task within 25-30 seconds, compared to control mice, who took almost double the amount of time, 45-50 seconds, to complete the task.

See also: Iuvone T, Esposito G, Esposito R, et al. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells J NEUROCHEM 89 (1): 134-141 APR 2004

CANTERPENE AS AN ANTIAGING STRATEGY

GOOD SCIENCE WITHOUT A METHOD TO GOOD SCIENCE WITHOUT A METHOD TO COMMERCIALIZE IT WILL NOT BENEFIT COMMERCIALIZE IT WILL NOT BENEFIT ANYONEANYONE

Morris/Greg/Leah/Erin Rod Fisher Steve Burnside