SDUMC-Path-CSBRP

Hyaline changeDr.CSBR.Prasad, M.D.

SDUMC-Path-CSBRP

Hyaline changeHyaline change (HC) (HC)

Def: Homogeneous glassy pink material in H&E stained sections which can occur both intra and extracellularly

Hyaline derived from Greek word ‘HyalosHyalos’HyalosHyalos = Glass

HC can result from accumulation of a variety different substances

It’s a descriptive histologic term not a It’s a descriptive histologic term not a specific marker of cell injuryspecific marker of cell injury

SDUMC-Path-CSBRP

Hyaline changeHyaline change (HC) (HC)

Intracellular hyaline change:Mallory bodiesHyaline droplets in Renal tubular cells in NSAlcoholic hyaline in LiverViral inclusionsRussel bodies

SDUMC-Path-CSBRP

Hyaline changeHyaline change (Russel bodies) (Russel bodies)

SDUMC-Path-CSBRP

Hyaline changeHyaline change (glomerular sclerosis) (glomerular sclerosis)

SDUMC-Path-CSBRP

Hyaline changeHyaline change (Protein droplets in (Protein droplets in renal tubular cells in NS)renal tubular cells in NS)

SDUMC-Path-CSBRP

Hyaline changeHyaline change (Mallory hyaline) (Mallory hyaline)

SDUMC-Path-CSBRP

Hyaline changeHyaline change (Mallory hyaline - IF) (Mallory hyaline - IF)

SDUMC-Path-CSBRP

Pituitary adenoma with Crooke's hyaline change Pituitary adenoma with Crooke's hyaline change

SDUMC-Path-CSBRP

Hyaline changeHyaline change (A1AT deficiency) (A1AT deficiency)

SDUMC-Path-CSBRP

Hyaline changeHyaline change (Viral inclusions)(Viral inclusions)

Molluscum contagiosum

SDUMC-Path-CSBRP

Hyaline changeHyaline change• Extracellular hyalin: occurs in connective tissue• Collagenous fibrous tissue in old scars may

appear hyalinized, but the physiochemical mechanism underlying this change is not clear.

• Hyaline arteriosclerosis of renal vessels in HTN• Hyalinization of glomeruli of kidney in chronic

renal disease• Also seen in RA, aging, chronic infection et.c.

SDUMC-Path-CSBRP

Hyaline changeHyaline change• Extracellular hyalin: occurs in connective

tissue

NOTE:• Amyloid should not be included under this

category as it’s a well studied different entity

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SDUMC-Path-CSBRP