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Overview on CELFIX DNA products.
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Carefree Skincare
CONFIDENTIAL
BY
Our Company
International skincare company based in the US
Focused on developing and commercializing innovative and highly efficacious anti-aging products that enhance the health and appearance of aging skin
Markets and sells cosmeceutical products to aesthetic professionals in order to meet the rapidly growing patient demand for skin rejuvenation products
Boasts an accomplished management team with 35+ years industry experience
CONFIDENTIAL
Our Philosophy
To provide our customers with cutting edge products that are sold through aesthetic professionals to meet the needs of the rapidly growing skin rejuvenation market
To produce only high quality products, having partnered with an FDA-approved manufacturer, to ensure excellence in product development and formulations
To be an industry leader in customer service excellence
To be a leading player in the aesthetic skincare marketplace worldwide
CONFIDENTIAL
Our Core Team
CONFIDENTIAL
Greg Chanitz
Randy Kriech
• Managing Partner• Founder
• Managing Partner• Founder
• VP of Sales/Marketing, PRIORI Skincare• VP of Sales/Marketing, Percos India• Regional Sales Director, Triax Pharma• Sr. Sales/Marketing Mgr, SkinMedica• Regional Sales Director, Elan Dermatology
• National Sales Director , AGI /Remergent• National Sales Director, Pierre Fabre / Avene• Regional Sales Director, Elan Dermatology• Director Business Development, Topiderm
The Skincare Revolution
CONFIDENTIAL
DNA repair is at the center of the coming revolution
Molecular biology applied to skin Most important risk to skin DNA is
the sun Sunlight causes DNA damage DNA repair enzymes excise DNA
containing damage Patched by the body’s natural repair
process
Point of Distinction
CONFIDENTIAL
UV
DNA Youth Recovery
DNA Damage Free Radicals
DNA Oxidation CellOxidation
ANTIOXIDANTSantioxidants
10x more thanoxidation
DNA Damage is 10 times more prevalent than free radical damage
The Next Wave in the Skincare Revolution
CONFIDENTIAL
Potent DNA repair enzymes Powerful antioxidants Unique formulas Next generation ingredients Precise delivery technologies Exceptional Results
Photodamage is Complex
Wrinkles Increased UV spots Loss of elasticity Hypo- and hyperpigmentation Increased skin cancer risk
CONFIDENTIAL
What is DNA Damage? The familiar double helix known as DNA is subject to thousands
of daily assaults: from the outside by radiation, pollutants and thermal damage; from the inside by replication errors and the body’s normal processes.
DNA is particularly susceptible to UV damage. While the skin’s own melanin and added sunscreen reflect or absorb a certain amount of light, enough solar radiation invariably gets through to the cell’s nucleus to directly damage DNA.
The skin is not defenseless. There are many DNA repair enzymes that spring into action when the cell is alerted to damage. The damaged strand is recognized and snipped out, and polymerases takes over, using the opposite strand as a template to guide the correction.
CONFIDENTIAL
In a 24 hour period, your body can only repair 50% of photodamage
DNA Damage (cont.) Everyone Needs DNA Repair Enzymes Some enzymes known as endonucleases assist in repairing the DNA by
seeking out the damaged DNA and sending a rallying call for the body’s own repair enzymes to remove lesions. Micrococcus luteus is one of the most UV-resistant microbes known to science.
Liposome delivery of this marine microbe recognizes cellular UV damage and accelerates the skin’s repair and recovery process.
Arabidopsis thaliana, also known as OGG1, is a second endonuclease repair enzyme found in the mustard plant. It targets both the nucleus and the energy-making mitochondria of the cell. OGG1 seeks out a common type of free radical damage to DNA and helps the body’s natural process by initiating the cellular repair process.
Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs. About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage.
The key to the effectiveness of these topically applied enzymes is their liposome delivery system, which transports them directly to the cells.
CONFIDENTIAL
DNA Repair Enzymes
CONFIDENTIAL
Anacystis nidulans Micrococcus luteus Arabidopsis thaliana
Enzyme Photolyase Endonuclease OGG1
Source Plankton Marine Micorbe Mustard Plant
Human Repair Photoreactivation Base Excision Repair
Base Excision Repair
Light Dependent Independent Independent
Speed Instant with Light 4-6 hours 4-6 hours
Immune System Protection Protection Not Known
Skin Protection Erythema Peeling Not Known
DNA Repair Enzyme - Micrococcus luteus
CONFIDENTIAL
Untreated
Treated with Micrococcus luteus Micrococcus luteus: liposome
delivery of this enzyme, sourced from marine microbes, recognizes cellular UV damage and accelerates the skin repair and recovery process
DNA Damage
DNA Repair Enzyme - Anacystis nidulans
CONFIDENTIAL
UV causes DNA damageLiposomes deliver photolyase into skinPhotolyase activity recognizes DNA
damageAbsorbs visible light and UVAReverses DNA damage
T T
DNA Repair Enzyme - Anacystis nidulans
CONFIDENTIAL
Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs.
About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage.
UV
UV+Photosomes
Human skin UVBDNA damage (green)
Anacystis nidulans light activation
DNA Repair Enzyme – Anacystis nidulans
CONFIDENTIAL
Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs.
About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage.
It takes 45+ minutes to reach sunburn with Anacystis nidulans vs. 15 minutes without
Micrococcus luteus and Anacystis nidulans
CONFIDENTIAL
Untreated
Treated with M. luteus & A. nidulans Micrococcus luteus + Anacystis
nidulans + visible light 6 hour results
DNA Damage
DNA Repair Enzyme – Arabidopsis thaliana
CONFIDENTIAL
Arabidopsis thaliana, also known as OGG1, is a second endonuclease repair enzyme found in the mustard plant.
It targets both the nucleus and the energy-making mitochondria of the cell.
OGG1 seeks out a common type of free radical damage to DNA and helps the body’s natural process by initiating the cellular repair process.
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Repairs oxidative damage to DNA• 90% elimination in 2 hrs
Liposome Delivery Most useful for being able to transfer and deliver active ingredients to the
application site of topical products
The liposome wall is very similar, physiologically, to the material of cell membranes
When a product containing liposomes is applied to the skin, the liposomes are deposited on the skin and begin to merge with the cellular membranes
In the process, the liposomes release their payload of active materials into the cells
As a consequence, not only is delivery of the actives very specific--directly into the intended cells--but the delivery takes place over a longer period of time
Liposomes are manufactured from various fatty substances that are used to encapsulate, or to create a sphere around, active materials, acting as a delivery system
CONFIDENTIAL
Restore & Defend with DNA Focused Skincare
CONFIDENTIAL
CONFIDENTIAL
CELFIX CosmeceuticalsDNA Youth Recovery
Facial Serum
DNA Youth Recovery CELFIX Cosmeceuticals: DNA Youth Recovery
Facial Serum50 ml / 1.7 oz.
Benefits: DNA technology for daily skincare 3 DNA Repair Enzymes Repair of UV and free radical damage Calms skin while speeding recovery Indicated for photo-damaged skin, lines, wrinkles,
& uneven skin tones
CONFIDENTIAL
DNA Youth Recovery cont. Makes use of targeted repair enzymes that are derived from
natural sources such as marine plankton and other plants Utilizes an encapsulated, liposomal delivery system to drive
the enzymes into the nucleus of the skin cell Employs a Chinese Evodia plant derivative which has been
proven through clinical studies to help calm and soothe irritated skin
Uses hyaluronic acid, which has the ability to retain 1000 times its weight in water, to help the skin maintain its youthful appearance
Has a non-comedogenic, paraben-free formula
CONFIDENTIAL
DNA Youth Recovery (cont.) Speeds up the DNA repair process, therefore, assisting in the
recovery from non-invasive procedures
Provides faster DNA recovery, which offers added protection to the UV damage suffered from sun exposure
Holds off collagen degradation in the lower layers of the skin, therefore helping to reduce the appearance of fine lines and wrinkles
Is a must if you are concerned about overall skin health
CONFIDENTIAL
Key Ingredients Micrococcus luteus: liposome delivery of this enzyme, sourced from
marine microbes, recognizes cellular UV damage and accelerates the skin repair and recovery process
Arabidopsis thaliana: liposome delivery of the repair enzyme known as OGG1, sourced from mustard seed, recognizes DNA damage and helps the body’s natural process by initiating the cellular repair process
Anacystis nidulans: liposome delivery of the repair enzyme photolyase, sourced from plankton, that can absorb and assist in reversing the effects of UV induced skin damage
Hyaluronic acid has the ability to retain 1000x’s its weight in water which contributes significantly to the skin maintaining its youthful appearance
Evodia rutaecarpa fruit extract is derived from the Chinese Evodia plant and has been proven to calm and soothe irritated skin
L-ergothioneine is a powerful antioxidant that absorbs free radical chain initiators and inhibits ROS triggered by environmental exposure
CONFIDENTIAL
To Be Clear CELFIX Cosmeceuticals: DNA Youth Recovery
First and foremost, the product does not repair damaged DNA
It assists in speeding up the body’s natural process to repair damaged DNA
Liposome-delivered enzymes adhere to the damage, extract the damage, and allow the DNA to repair itself
This is what the body naturally does
However, the body can only repair 50% of the damage it receives in any given day
DNA Youth Recovery helps repair the other 50%
CONFIDENTIAL
How It Works Plant-derived enzymes mimic the body’s natural response
Enzymes are encapsulated in a liposomal delivery system which drives the enzymes into the nucleus of the skin cell
The cargo is released into the cell, searches and adheres to the damaged DNA strand only (search & destroy)
Damage is then extracted or cut out similar to the body’s natural response
DNA mimics clean strand and replicates to a healthy cell
CONFIDENTIAL
Who Needs CELFIX Cosmeceuticals: DNA Youth Recovery
Anyone concerned with overall skin health
Anyone overexposed to the sun, past and present
Anyone exposed to environmental pollutants
Anyone concerned with fines lines, wrinkles and UV spots
Anyone recovering from a non-invasive procedure
Everyone needs help repairing damaged DNA
DNA Youth Recovery is engineered to fit with all skin types and current protocols, therefore, anyone can use it
CONFIDENTIAL
Benefits CELFIX Cosmeceuticals: DNA Youth Recovery By assisting in DNA repair, it helps the skin recover from non-
invasive procedures Because it helps the skin repair the “other” 50% of damaged
DNA, it provides faster DNA recovery, which offers added protection/prevention to the UV damage suffered from sun exposure
Holds off collagen degradation in the lower layers of the skin, therefore, helping to reduce the appearance of fine lines and wrinkles
Has a non-comedogenic, paraben-free formulation Fits perfectly with all skincare regimens Attacks both past and present damage!!
CONFIDENTIAL
CONFIDENTIAL
CELFIX Cosmeceuticals DNA Ceramide Renewal
Nourishing Cream
Skin Barrier Barrier function in the skin depends on ceramide lipids. Ceramides are fatty cells essential to a strong barrier
They are located in stratum corneum of skin and are an important part of the lipid barrier of the human skin which plays an essential role keeping the protective function of the skin against external insults and the hydration balance needed for its good conservation
Barrier is outer layer of skin and should be strong not necessarily thick
Protects the skin from the UV rays and environmental insults Building a better skin barrier:
– Apply topical ceramides– Accelerate keratinocyte maturation- late stage ceramide production– Stimulate keratinocyes to increase ceramides
CONFIDENTIAL
DNA Ceramide Renewal CELFIX Cosmeceuticals: DNA Ceramide
Renewal Nourishing Cream 50 ml / 1.7 oz.
Benefits Contains 1 DNA Repair Enzyme Builds upper skin barrier w/ ceramides
and antioxidants Strengthens lower collagen layer Reduce irritation and keeps skin moisturized Stronger protection from the inside out!
CONFIDENTIAL
DNA Ceramide Renewal One pump for face, throat and decollete
Once or twice daily, morning & night after cleansing and other treatments, before sunscreen
Patient Types:
Any patient post procedure
Men: post shave
Any patient w/ a compromised skin barrier
Any patient concerned with overall skin
health
CONFIDENTIAL
Key Ingredients Rosemary extract or ursolic acid is a natural component that provides a
boost to the skin’s natural ability to increase ceramide production Lactomide is an aqueous patented liposome dispersion containing a
naturally derived ceramide (Ceramide-3) as well as milk lipids. Lactomide improves the constitution and structure of the barrier and therefore has a positive effect on skin hydration and reversing the signs of aging
Arabidopsis thaliana: liposome delivery of the repair enzyme known as OGG1, sourced from mustard seed, recognizes DNA damage and helps the body’s natural process by initiating the cellular repair process
L-ergothioneine is a powerful antioxidant that absorbs free radical chain initiators and inhibits ROS triggered by environmental exposure
Evodia rutaecarpa fruit extract is derived from the Chinese Evodia plant and has been proven to calm and soothe irritated skin
Glycerin is a highly “hygroscopic” ingredient that helps to balance or maintain moisture levels in the skin
CONFIDENTIAL
Rosemary Extract Increases Ceramides
CONFIDENTIAL
Per
cen
t C
eram
ides
Skin Lipids Increased Ceramides
30% Increase in 11 Days
Antioxidant ORAC Scores
CONFIDENTIAL
CELFIX Testimonial
CONFIDENTIAL
Tina S. Alster, MD, FAAD Director, Washington Institute of Dermatologic Laser Surgery Clinical Professor of Dermatology, Georgetown University Medical Center
“The impressive science-based technology of CELFIX DNA Youth Recovery makes it an important component of my patients’ anti-aging skin care regimens. The formulation can easily be incorporated into a variety of existing skin care protocols to enhance the skin’s appearance.”
CELFIX Testimonial
CONFIDENTIAL
Vivian Bucay, MD, FAAD Medical, Surgical & Cosmetic Dermatology San Antonio, TX
“As a stage IV melanoma survivor, the topic of DNA repair intrigues me. In clinical practice, I have found a product known as CELFIX DNA Youth Recovery (Carefree Skincare) to be very similar to the original Remergent DNA repair. An unpublished study performed in my clinic involving approximately 100 patients demonstrated that after three months of twice daily application, a 40-50 percent reduction in UV spots was achieved as measured by the VISIA Complexion Analysis.”
Clinical Analysis of CELFIX Products
CONFIDENTIAL
VISIA Complexion Analysis (Canfield Imaging Systems) Multi-spectral imaging, using
standard & UV photography Quantitative assessment of
sub-surface conditions Fixed positioning & lightening
to ensure accurateness of images between time points
20% Reduction in UV Spots in 4 Weeks
CONFIDENTIAL
Before: 342 UV Spots After: 4 Weeks: 271 UV Spots
Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.
41% Reduction in UV Spots in 8 Weeks
CONFIDENTIAL
Before: 228 UV Spots After: 8 Weeks: 135 UV Spots
Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.
70% Reduction in UV Spots in 12 Weeks
CONFIDENTIAL
Before: 217 UV Spots After: 12 Weeks: 64 UV Spots
Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.
CONFIDENTIAL
CELFIX CosmeceuticalsDNA iQuad Infusion
Total Eye Complex
DNA iQuad Infusion CELFIX Cosmeceuticals: DNA iQuad Infusion
Total Eye Complex15 ml / 0.5 oz.
Benefits: 1 DNA Repair Enzyme Reduces appearance of lines & wrinkles Diminishes dark circles Treats photodamage Lessens the appearance of puffiness
CONFIDENTIAL
DNA iQuad Infusion cont. Matrixyl 3000, a combination of peptides that helps regulate
cell activity and works together to help restore and maintain the skin’s youthful appearance. Studies show a 45% reduction of wrinkles in 8 weeks.
Haloxyl is a combination of peptides that helps activate the elimination of blood originated pigments responsible for dark under-eye circles and puffiness while reinforcing firmness of the eye area.
Photolyase Liposomes, an organic DNA recovery enzyme derived from plankton which helps reverse photo damage and eliminate the appearance of UV spots on the skin.
CONFIDENTIAL
Key Ingredients
CONFIDENTIAL
Reduces Lines & Wrinkles
Diminishes Dark Circles
Lessens Puffiness
Combats Photodamage
Smoothes Skin Protects Moisturizes
Matrixyl 3000 X X Haloxyl X X Photolyase X X Caffeine X X X X Sunflower Seed Oil X XIvy Extract X Green Tea Extract X Sodium Hyaluronate X X XLicorice Extract X X Ergothioneine X Tocopherol X X XUbiquinone X X X X
45% Reduction of Wrinkles in 8 Weeks
CONFIDENTIAL
Baseline Week 8
Under-eye Circles Reduced in More Than 60% of Patients
CONFIDENTIAL
Dark circles significantly reduced by 19% in 8 weeks.
The Next Wave In The Skincare Revolution
CONFIDENTIAL