By Ifsha Akhlaq

New suggested treatment of

Definition Symptoms Causes Risk factors Complications Mechanism of vitamine D production Mechanism of rickets Present treatment My suggestion

Contents

Rickets is the softening and weakening of bones in children, usually because of an extreme and prolonged vitamin D deficiency.

Definition

Delayed growth Pain in the spine, pelvis and legs Muscle weakness Bowed legs Thickened wrists and ankles Breastbone projection

Symptoms

Deficiency in Vitamin D Calcium phosphorous

Caused by

Age Dark skin Premature birth Anti-seizure medications Exclusive breast-feeding.

Risk factors

If left untreated, rickets may lead to: Failure to grow Abnormally curved spine Skeletal deformities Dental defects Seizures

Complications

Mechanism of vitamine D production

In rickets condition

 vitamin D and calcium supplements Surgical and other procedures

Present treatment

During breast feeding give oral vitamin D daily(400 IU drops)

Increase the activity of 1 α hydroxylase Decreased the activity of 24 hydroxylase

My suggested treatment

Rocaltrol Which is commonly used in managment of

hyperparathyriodismAlso enhances calcium absorption

Use other drugs

Calderol commonly used as hypoparathyroid agents in some areas also used as vitamin d in the

treatment of rickets

PTH increases the activity of 1-α-hydroxylase enzyme, which converts 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, the active form of vitamin D.

Role of parathyroid hormone in rickets

We can increase the production of parathroid hormone

Suggested treatment

http://www.mayoclinic.com http://www.betterhealth.com http://www.rxlist.com Journal of immunology Baltimore,Md:1950

Referances