Question 1:Can we identify an individual marker of brain maturity using whole-brain gray matter volume?

Fran

ke e

t al, 2

01

2

Spin into potential hemispheric specific maturation

R T

oro

Testing Feasibility

Question 2What are the volumetric subcortical relationships with age (amygdala, thalamus caudate, hyppocampus)

…..to be continued

Question 3a:What is the trajectory and

nature of abnormal neurodevelopment in

ASD?

Question 3b: And what are the most

sensitive metrics for measuring

neurodevelopment?

Question 4:Will group differences between a young cohort A and an older cohort B be “the same” as differences seen between two other randomly selected, age-matched cohorts C and D?

* Outcomes of interest: 1. overall brain volume 2. volume of subcortical structures