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Adichunchanagiri
Institute of Medical
Sciences
Chief Patron
Paramapoojya
Sri Sri Sri
Nirmalanandanatha
Mahaswamiji
Chief Advisor
Dr. Shivaramu M.G.
Principal A.I.M.S.
Chief Editor
Dr. Aliya Nusrath.
Professor & Head
Dept. of Biochemistry
Editorial Board
Dr. N. Asha Rani.
Asst. Professor
Dr. Prathibha K.
Asst. Professor
Dr Namitha D.
Tutor cum PG
Members
Dr. Rajeshwari A.
Assoc. Professor
Dr. Chikkanna D.
Assoc. Professor
Sri. Somashekar G.N.
Asst. Professor
Dr. Shilpashree Y.D.
Asst. Professor
Dr. Reshma D.
Asst. Professor
Mrs Rafiya Begum.
Tutor
Contact information:
Biochemistry - Medicine at molecular level
Biomed Dept of Biochemistry
___________________________________________________
News letter VOLUME 2 ISSUE 1 JAN 2015
___________________________________________________
From Editor’s Desk Greetings
“The doctor of future will give no medicine but will interest
her or his patients in the care of human frame, in a proper diet and in
the cause and prevention of disease”– Thomas Edison.
In todays world of rising prevalence of noncommunicable
diseases due to adverse lifestyle and unhealthy dietary habits, creating
awareness of ideal nutrition and its relation with health and disease
was never more important than before. Hence in our first community
extension service, we actively celebrated the nutrition week by giving
seminar to school children on importance of nutrition.
Department staff Front Row (from left to right): Dr Reshma D, Dr. N Asha Rani, Dr Chikkanna D, Mr Somashekhar GN, Dr Rajeshwari A,
Dr Aliya Nusrath, Mrs Rafiya Begum, Dr Prathibha K, Dr Namitha D
and Dr Shilpashree YD.
Back Row (from left to right): Mr HongereGowda, Mr Mahalinge
Gowda, Mr Shankere Gowda, Mr Krishne Gowda and Mr Yateesh NR.
Vitamin P is a noble discovery
Vitamin P was discovered by Nobel Prize winning scientist Albert Szent-Gyorgyi in1936. Vitamin P is
also known as flavonoids. Bioflavonoids are powerful anti-oxidants, which slashes cancer risk, and
slows tumor growth. Two important bioflavonoid are well known and these are quercetin and rutin.
Quercetin has been found to be active against cancers: breast, prostate, colon, gastric, head and neck,
leukemia, lung, melanoma, liver, ovarian, and cervical. Rutin is known for its ability to strengthen
capillary walls. Clinically, bruises that easily occur may be a sign of weak capillary walls.
Bioflavonoids according to some of the latest scientific findings are responsible for an infinite array of
protective effects. The list of benefits include: better circulation, stimulates bile production, prevents and
may reverse cataracts, strengthens capillaries, reduces stroke risk, and lowers LDL (bad) cholesterol.
Rutin treats varicose veins, glaucoma, hay fever, haemorrhoids, and reduces allergy symptoms.
Food Sources: The dietary options include the most commonly eaten foods. Vitamin P is essential to the
absorption and utilization of vitamin C. One of the best sources of bioflavonoid is in vitamin C rich
foods such as citrus. The perfect way to get vitamin P and C together is in oranges, grapefruits, lemons,
tangerines, and tangelos. The vitamin P is in the white material beneath the citrus peel. Other vitamin P-
rich foods include green peppers, broccoli, buckwheat, nuts, seeds, grains, legumes, cacao, and red wine.
The unrivalled list of foods with some bioflavonoid include: apples, apricots, black currants, cherries,
grapes, green tea, milk thistle, onions, strawberries, tomatoes, mango, and prunes.
Dr Prathibha K, Asst. Professor, Dept. Of Biochemistry
Laminin Subunit alpha -5
Laminin subunit alpha-5 is a protein that is encoded by the LAMA5 gene. Laminin-5 (α3β3γ2;
laminin-332), abbreviated as LN5, is a major laminin isoform in the skin basement membrane and
expressed in other epithelial tissues as a relatively minor component. Human LN5 is synthesized and
secreted as a precursor form consisting of a 190-kDa α3 chain, a 135-kDa β3 chain, and a 150-kDa γ2
chain. After secretion, the α3 and γ2 chains undergo specific extracellular proteolytic processing to
convert to the mature form containing a 160-kDa α3 chain and a 105-kDa γ2 chain, respectively. The
proteolytic cleavage of the 190-kDa α3 chain, which occurs between the LG3 and LG4 modules in the G
domain, increases the biological activity of LN5. The processing of the 150-kDa γ2 chain to the 105-
kDa mature form decreases the cell adhesion activity but increases the cell migration activity of LN5.
Bone morphogenic protein-1/mammalian Tolloid metalloproteinase family, including mammalian
Tolloid-like-1 and mammalian Tolloid-like-2, are thought to be responsible for the γ2 chain processing
in human LN5.Furthermore, many immunohistochemical studies have shown that the laminin γ2 chain is
overexpressed at the invasion front of human cancers. In vitro, LN5 strongly promotes cellular
scattering, migration, and adhesion through the interaction with integrins α3β1, α6β1, and α6β4. The cell
adhesion activity of LN5 contributes to the tight adhesion of basal keratinocytes to the underlying
connective tissue in the skin, which is mediated by the association of LN5 with integrin α6β4 in the
hemidesmosome structures. Therefore, structural defects of LN5 subunits, integrin α6β4, or other
hemidesmosome components cause severe skin blistering in humans and experimental animals. In
contrast, the cell migration-promoting activity of LN5 is thought to contribute to wound healing and
tumor invasion.
Dr Namitha D. Post Graduate. Dept. Of Biochemistry
Important Events in the Department Celebration of Nutrition week: “Let food be thy medicine and medicine be thy food.” ― Hippocrates
The need of the hour
in higher education is
innovative teaching practices
and community based
services. First week of
September is celebrated as
nutrition week to create
awareness regarding the
importance of nutrition and
diet in health and disease.
The department takes pride
in the celebration of
Nutrition week in its first
community extension
service. A seminar was
organized on “Importance
of Nutrition in health and
disease” on 8th
September
2014 at the premises of BGS
Model Public School to
create an awareness
regarding nutrition and its
importance in health and
disease among 1st standard
(5-6 year old) school
children. The speakers of the
day were Dr. N. Asha Rani, Dr Shilpashree Y D and Dr Reshma
D, Assistant Professors in the department.
Hearty Congratulations
1. Our staff Dr Shilpashree YD,
Asst. Professor secured Gold
Medal in Preclinical Post Graduate
examination from JSS university,
Mysore. A hearty congratulations.
2. Our own Post Graduate Dr.
Prathibha K, joined the
department as Assistant professor.
We welcome her back to our
family of Biochemistry.
.
Dr Shilpashree YD. receiving the Gold medal Dr Prathibha K
from Mr. Ananthkumar
Guest Lecture: Another feather in our cap was organization of Guest lecture on 31
st October 2014 on “Genetic
Engineering: Making Molecular Biology Work for Preclinical Research” by eminent speaker Dr.
Raghavendra Prahallad Rao, Lead scientist, Connexios life science Pvt. Ltd. Bangalore.
Integrated Seminar: “In learning you will teach and in teaching you will learn” – Phil Collins.
Integrated students seminars are important tools of teaching learning. Integrating the basic sciences
with clinical skills helps in complete understanding of all the concepts of a medical condition, thus
contributing to total management of this medical condition in patient care. The department is
conducting integrated seminar not only for undergraduates but also postgraduates.
1. To mark the celebration of World diabetes day on 14th
November 2014, an integrated post
graduate seminar between our department and Medicine department was organized in the department.
Dr. Namitha D, 2nd
year Post Graduate, Dept of Biochemistry presented lecture on ‘Biochemical
alterations and role of Laboratory Medicine in Diabetes Mellitus” and Dr. Vikas Naik, final year Post
Graduate, Dept of Medicine presented lecture on “Approach to management of Type 2 Diabetes
Mellitus”
2. An integrated undergraduate seminar will be organized in collaboration with Anatomy and
Physiology department (pre clinical departments) on 29th
January 2015 for the topic Thyroid gland.
The good Physcian treats the disease, the great phycian treats the person
who has the disease – William Osler
Students Projects : Effective teaching in medical
field requires that teachers
address learner’s needs. In
present day, the teachers are
considered as facilitators who
guide the students and motivate
the students in self directed
learning. If teachers use a
variety of teaching methods and
styles, learners are exposed to
both familiar and unfamiliar
ways of learning which provide
both comfort and tension during
the process, ultimately giving
learners multiple ways to excel.
The department thus
recognizes the needs of slow,
moderate and fast learners and
approaches these students with
different teaching methods.
Apart from remedial classes the
students are involved in a
variety of student activities
including model making.
The students highlighted
importance of balanced diet by
making food pyramid models.
Model making by Ms Anitha K, Ms
Babishiya, Ms Brunda, Ms
Chaitanya, Ms Cliffin, Ms Deepiga,
Ms Gowri, Ms Hajira, Ms
Madhumitha, Ms Manisha and Ms
Priyadarshini.
Chart making by Ms Praphita SP
and team, Mr Sachin P Shaji and
team, Ms Sayanvtha M and team,
and Sreenu CP and team.
List of Publications in 2014
1. Aliya Nusrath, Prathibha K, Rajeshwari A. Evaluation of Cardiovascular Risk Factors in Psoriasis
Patients.International Journal of Recent Trends in Science And Technology 2014;9(3):328-31.
2. Mahantesh Patil, Nirmal Kumar, Aliya Nusrath, Shubha Jayaram, Rajeshwari A. Association of HbA1c with serum
lipid profile and lipoprotein (a) in type 2 Diabetes Mellitus. Int J Cur Res Rev, 2014; 6(6): 20-24.
3. Divija DA, A Rajeshwari and Aliya Nusrath. Correlation of serum sialic acid with glycemic status in diabetic
nephropathy International journal of bioassay,2014;3(2) :1789-93
4. Maithri CM, Aliya Nusrath, Shrinivasa BM, Rajeshwari A .Correlation of Glycemic status with Oxidative/antioxidant
status in diabetic retinopathy. International journal of contemporary Medicine.2014;2(1):66-9
5. Shilpashree Y.D., Devaki R. N., Suma M. N., Prashanth V. Appraisal of oxidative stress markers and antioxidant
status in diabetic Neuropathy. International Journal of Recent Trends in Science and Technology 2014;11(3):313-315.
6. Suma M N, Reshma D, Evaluation of Serum Uric Acid and Serum Gamma Glutamyl Transferase in Patients with
Metabolic Syndrome. IOSR Journal of Dental and Medical Sciences 2014; 13(7): 98-103.
7. Shilpashree Y.D., Suma M. N., Devaki R. N., Prashanth. Evaluation of oxidative stress markers and antioxidant status
in diabetic retinopathy. International Journal of Recent Trends in Science and Technology 2014;12(2):239-242
8. N. Asha Rani, J N Naidu, Krishnamma. Evaluation of Nitric Oxide and Reduced Glutathione Levels in Preeclampsia.
IJBRITISH 2014;1(4):13-17.
Fun and Learn Biomed Crossword
(Crossword on Carbohydrates) Across
3. carbohydrate of plants (6)
6. An aldopentose (6)
7. A storage disease (4)
8. A product of anaerobic pathway (7)
9. A carbohydrate used in media (4)
10. The sugar of life (7)
12. A carbohydrate partially soluble in water,
good for bowls (6)
15. A splitting enzyme in carbohydrates (8)
16. Abbreviation of a substrate of TCA cycle
(3)
17. First synthesized pentose in alternate
pathway of glucose oxidation (8)
Down
1. An intermediate in carbohydrate
metabolism which acts as catalyst (12)
2. Storage form of Glucose (8)
4. Random carbohydrate levels in blood (3)
(Abbreviation)
5. An activator of lipoprotein lipase (7)
7. A hexasaccharide (6)
11. The sugar of genetic material (6)
13. Name of a disease as well as a cycle (4)
14. The other name of sialic acid (4)
(Abbreviation)
By Dr Aliya Nusrath, Prof and HOD Answers will be given in next issue
1 2 3 4 5
6
7
8
9
10
11
12
13 14
15 16
17
Results of 1st MBBS 2013-14 Batch
We are proud of the performance of 2013- 14 batch
which passed out with flying colours with an
excellent pass percentage of 83.5%. Forty (30%)
students secured Distinction (≥75%) and fifty one
(38%) students secured 1st class.
The batch topper was Mr Rahul Jain with 79.8 %.
Biochemistry subject topper was Mr Pramit
Mukherjee with 84%.
Mr. Pramit Mukherjee Mr. Rahul Jain
