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BACTERIAL

INFECTION AND

IMMUNE

SYSTEM

RESPONSE

DIANA AGUDELO JARAMILLO

MEDICINE STUDENT

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INTRODUCTION

CELLS

Eukaryotic

Nuclear membrane and cytoplasm

organelles.Human cells

Prokaryotes

Doesn’t have a nuclear membrane and the genetic material is

dispersed in the cytoplasm

Bacteria

Pathogenic bacteria to the body.

No pathogenic Bacteria on the body.

+TYPHOID FEVER: A RACE AGAINST TIME

Constantly the body istrying to protect himselfof the pathogenicmicroorganism that canaffect significantly.

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TYPHOID FEVER:

A RACE AGAINST

TIME

Neutrophils and monocytesenclose the bacteria to formabscess. But some of them canescape and continue infecting

+TYPHOID FEVER: A RACE

AGAINST TIME

Although the immune cells

kill a lot of bacteria

Salmonella, there are others

that evade that abscess and

escape, guaranteed his

survival and his replicates in

all the body.

+ TYPHOID FEVER: A

RACE AGAINST TIME

Salmonella

Food or water contaminates

Begins on the intestine and then invades other organs

typhoid fever particularly insidious

CONSTANTLY ANTIBIOTIC RESISTANT

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STUDENT OBSERVATION

It is important to

further scientific

development in

these areas to

achieve eradicate

Salmonella, who

generate resistance

even faster than the

creation of new

antibiotics.

+ Steps leading to necrotizing

fasciitis revealed, opening way to

possible new treatments for

bacterial infections

Group A Streptococcus (GAS) or S.

Pyogenes, is a silent bacteria that colonize

the body without produce any symptoms and

can be mortal in a lot of cases such as toxic

shock syndrome and streptococcal

necrotizing fasciitis (flesh-eating disease)

+ STEPS LEADING TO NECROTIZING

FASCIITIS REVEALED, OPENING WAY TO

POSSIBLE NEW TREATMENTS FOR

BACTERIAL INFECTIONS

Once the bacteria

enter to the

cell, liberates two

streptolysins that

inhibit the synthesis

of proteins in the

cytoplasm.

BACTERI

A

CELL

STREPTOLYSINS

mRNA

+ STEPS LEADING TO NECROTIZING

FASCIITIS REVEALED, OPENING WAY TO

POSSIBLE NEW TREATMENTS FOR

BACTERIAL INFECTIONS

The human cells

increases the

production of the

amino acid

asparagine as a

method of defence

that alters gene

expression of

GASand increases

his virulence. ASPARAGINE

+STEPS LEADING TO

NECROTIZING FASCIITIS

REVEALED, OPENING

WAY TO POSSIBLE NEW

TREATMENTS FOR

BACTERIAL INFECTIONS

Asparaginase degrades

asparagina. Thats why they use

it to reduce the growth of GAS

in human blood and mouse

models of human infection.

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Asparaginase has never before used to treat GAS infections.

Knowing the metabolic changes occurring between the

pathogen and its host´s infection can lead to develop a few of

effective treatment against infection diseases.

STUDENT OBSERVATION

+MEDICAL UTILITY

The doctors, food distributors,

among many other companies,

are straining to maintain the

necessary hygiene for disease

control in clients, workers or

patients.

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MEDICAL UTILITY

As health workers, we should

alert people about this kind of

diseases that are so contagious

and how they can prevent

them.

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Someexamples can betaking care of his ownbody, washing hands with avery good disinfectant andnot consuming food whichhas expired date ofcaducity, also prevent thetransmission, trying to coverthe mouth whensneezing, or not share stuffthat can have contact withfluids or blood of our body.

MEDICAL UTILITY

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With the development of the studies about the virulence of

those bacterias and how can they affect us, we can investigate

more about a lot treatments that can helps to control the early

effects that cause a lot of damage even if we don't feel any

symptom, reducing the annual number of deaths.

MEDICAL UTILITY

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REFERENCES

1. 1. MARTÍNEZ SANCHEZ, LinaMaría; et alt. Biología molecular. 7th ed. Medellín, Col: Universidad PontificiaBolivariana; 2012.

2. BROOKS, GF; CARROLL, KAREN; BUTEL, JANET; MORSE, STEPHEN; MIETZNER, TIMOTHY. Jawetz, Melnick y Adelberg, MicrobiologíaMédica. (2010). 25 Edición. Mc Graw Hill. Mexico, DF. PP: 145,147,159,160.

3. niversität Basel (2014, January 16). Typhoid fever: A race against time. ScienceDaily. Retrieved January 25, 2014, from http://www.sciencedaily.com­/releases/2014/01/140116085053.htm.

4. The Hebrew University of Jerusalem. (2014, January 20). "Steps leading to necrotizing fasciitis revealed, opening way to possible new treatments for bacterial infections." Medical News Today. Retrieved fromhttp://www.medicalnewstoday.com/releases/271385

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“As we look higher, we get higher”