Curcumin’s Therapeutic Effects On

Inflammatory Bowel DiseaseReview paper presentation

Angélica M. González SánchezDecember 2, 2011.

BIOL 3095 - UPR Cayey

What is IBD? Severe inflammation of the gastrointestinal wall.

Rare condition statistically - its implications on people’s quality of life make it a relevant field for investigations.

Unknown causes – linked to genetic, environmental and immunological factors

- Stress response

- uncontrolled pathways of molecules related to the immune system.

,

Healthy Colon

Ulcerative Colon

Healthy Small Bowel

Images from: virtualmedicalcentre.com, bidmc.org, hopkins-gi.org

Crohn’s disease Small

Bowel

Types of IBD

Complications and treatments:

Images from: ehow.com, doccarnahan.blogspot.com

What is curcumin?Diferuloylmethane

Image from: Anand P, Thomas S, Kunnumakkara A, Sundaram C, Harikumar K, Sung B, Tharakan S, Misra K, Priyadarsini I, Rajasekharan K, Aggarwal B. 2008. Biological activities of curcumin and its

analogues (Congeners) made by man and Mother Nature. Biochemical Pharmacology Journal. 76(1):1590-1611.

Obtained from the roots of the herb Curcuma longa.

Traditionally used in foods as a component of the spice turmeric and as an herbal remedy for several illnesses.

Image from: aliexpress.com

Antioxidant, anti-inflammatory, antimicrobial and anti-carcinogenic activities.

(Anand et al., 2008)

Reasons for its capacities are not well known.-Linked to its ability to bind to several proteins and regulatory enzymes and to inhibit oxidation chain reactions. (Srivastava et al., 2011)

Regulates the presence of several molecules.

- cellular processes → stress response. - Transcription factors, enzymes and

proteins→ directly related to immunity and

inflammation.

Macroscopic effects of curcumin on IBD

Decrease of inflammation

on the intestinal tissues

Weight gainIncrease in the rate of

survival

Related to microscopic processes of the cell

(Jian et al., 2005) (Salh et al., 2003)

Deregulated molecules on IBD

Deregulated molecules that cause inflammation

on IBD

NF-κB

cytokines:- inflammatory ones (as IL-1β) are

over expressed- anti-inflammatory ones (as IL-10)

are under expressed

chemokines

p38 MAPK

lymphocytes

chemokines

cyclooxygenases & lipoxygenases

MPO hypoclorous acid radical & tyrosyl radical

(Jian et al., 2005) (Salh et al., 2003)(Srivastava et al., 2011)

Microscopic effects of curcumin on IBD

- Regulates the NF-κB pathway, therefore, reduces IL-1β expression & increases IL-10

expression.

- Inhibits the excessive proliferation of white blood cells.

-Diminishes the activation of p38 MAPK, therefore controlling the production of

lymphocytes, chemokines, cyclooxygenases and lipoxygenases.

- Inhibits the oxidation of MPO by oxidizing itself, therefore, preventing that the free

radicals run freely in the body and reducing the oxidation chain reactions.

(Rajasekaran, 2011)(Srivastava et al., 2011)(Salh et al., 2003)

Curcumin’s usage and limitations

(Anand et al., 2008)(Srivastava et al., 2011)(Rajasekaran, 2011)(Yadav et al., 2009)

Conclusions Not so many researches = many aspects not

well comprehended = more research is needed.

Not all of the research has concluded curcumin’s effects in all the same molecules, but all of them have related its outcomes on its regulatory properties.

Good modulator of the appropriate quantities of molecules needed for stress response → related to IBD.

ReferencesAnand P, Thomas S, Kunnumakkara A, Sundaram C, Harikumar K, Sung B, Tharakan S, Misra K, Priyadarsini I, Rajasekharan K, Aggarwal B. 2008. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochemical Pharmacology Journal. 76(1):1590-1611.

Jian Y, Mai G, Wang J, Zhang Y, Luo R, Fang Y. 2005. Preventive and therapeutic effects of NF-kappaB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid. World Journal of Gastroenterology. 11(12):1747-1752.

Pithadia A, Jain S. 2011. Treatment of inflammatory bowel disease (IBD). Pharmacological Reports. 63(1):629-642.

Rajasekaran S. 2011. Therapeutic potential of curcumin in gastrointestinal diseases. World Journal of Gastrointestinal Pathophysiology. 2(1): 1-14.

Salh B, Assi K, Templeman V, Parhar K, Owen D, Gómez A, Jacobson K. 2003. Curcumin attenuates DNB-induced murine colitis. American Journal of Physiology Gastrointestinal and Liver Physiology. 285:G235-G243.

Srivastava R, Singh S, Dubey S, Misra K, Khar A. 2011. Immunomodulatory and therapeutic activity of curcumin. International Immunopharmacology Journal. 11(1):331-341.

Yadav V, Suresh S, Devi K, Seema Y. 2009. Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model. AAPS PharmSciTech. 10(3):752-762.

Questions?

Image from: ibstreatmentcenter.blogspot.com

Thanks for your

attention!