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AIDSPrepared By : Ahmadullah Sial Niazi and Sadullah Nihal Niazi
GHALIB UNIVERSTIYKABUL
AFGHANISTAN
Introduction Epidemiology Etiology Structure of HIV Life Cycle of HIV Clinical Features
Contents :
AIDS : Acquired Immunodeficiency Syndrome HIV : Human Immunodeficiency Virus
Retroviral disease caused by HIV
Depletion of CD4+ T lymphocyte
Opportunistic infection and neoplasms
Introduction :
African green monkey (SIV) , Sootey mangabey (HIV-2) , Chimpanzee (HIV-1)
Sexual Transmission - Homosexual - Heterosexual
Parenteral Transmission - Intravenous drug abusers - Hemophiliacs - Blood transfusion
Epidemiology
Mother-to-Infant Transmission - During Pregnancy - During Delivery - Breast Feeding
HIV can’t be transmitted through:1- Air2-personal contact3-insect bites4-saliva 5-tears
AIDS is caused by HIV belonging to Lentivirus family.
HIV-1 HIV-2
Etiology :
Structure of HIV virus
Life cycle of HIV
Virus-induced self destruction
Targeting by the body own immune system cells
How are CD4 T-cells depleted?
Acute Phase - 50-70% affected people - 3-6 weeks - Sore throat, Myalgia, skin rash, Fever ,Aseptic meningitis
Clinical Features :
Chronic Phase - may last for several years - patient often asymptomatic or often (Lymphadenopathy , (candida) , herpes zoster)
Clinical Features :
Crisis Phase - breakdown of host defenses , Viremia and clinical diseases - Fever (30 + days), fatigue, weight loss and diarrhea - CD4 cells less than 500 cells /
Clinical Features :
Antiretroviral Therapy
Acupuncture
Treatment :
AIDS caused by HIV which kills CD4 T-cells.
Transmission (sexual , blood , mother to infant)
HIV penetrate in CD4 T-cells and replicates
CD4 cells killed directly or killed by body immune sys
Three stages of AIDS : 1-Acute 2-Chronic 3-Crisis
Summary :
THANKS!!!