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Folate
Introduction
• Folate, commonly known as folic acid, functions together with a group of related water-soluble compounds, called folacin,
• It is critical to cellular division b/c it is necessary in DNA synthesis DNA synthesis
• Folate, maintains the cell’s genetic code and transfer inherited traits from one cell to another
• It is vitally important for the fetal development of nerve cells, and its deficiency during pregnancy has been linked to several birth defects
• Supplements of folic acid should be considered by all women of reproductive age
Causes of FD
• Is caused primarily by inadequate dietary intake• Typical folate intakes are suboptimal in the diets of many
women of childbearing age, • folate intake is further limited by cooking losses and
poor bioavailablity,poor bioavailablity,• Folate deficiency can also be a consequence of medical
conditions that increase the need for folate or result in increased excretion of folate, including
• pregnancy, lactation, alcoholism, malabsorption, kidney dialysis, liver disease, certain anaemias and medications that interfere with folate metabolism
Consequences
• Hemolytic and megaloblastic• Irritability • Lack of energy, Weakness • Sleeping difficulties Sleeping difficulties • Paleness • Sore red tongue • NTD in the fetus• Mild mental symptoms, such as forgetfulness and
confusion • Diarrhea
Food SourcesPLANTS ANIMALS
• Cereals (Wheat, Rice, Wheat germ)
• Legumes (Peas, Soybeans, Split peas,
Lentil, Garbanzo beans, (chickpeas)
Calves' liver
• Fruits (Orange juice, Oranges)
• Vegetables (GLV , Sprouts)
Functions
• Promotes normal red blood cell formation. • Maintains nervous system, intestinal tract, sex organs,
white blood cells, and normal patterns of growth• Regulates embryonic and foetal development of nerve
cells• Promotes normal growth and development• Promotes normal growth and development• Acts as co-enzyme for normal DNA synthesis. • Functions as part of co-enzyme in amino acid and
nucleoprotein synthesis. • Promotes normal red blood cell formation• Essential for the methylation of important substrates
(methylation of myeline basic protein) –methylation cycle
Summarized Functions
Global magnitude
• Folate deficiency is a serious problem that affects women worldwide
• Up to a third of all pregnant women reported by WHO in the world have folate deficiencies
• The problem is high in developing countries • The problem is high in developing countries with more cases from SSA
Cont…
National Status• Information on the prevalence of folate
deficiency is limited to one study ofpregnantwomen
• To date, the first large assessment of women’s nutritional status in Ethiopia was undertaken in nutritional status in Ethiopia was undertaken in 1995
• Forty-six per cent of women had severe FD (≤ 4 ng/mL) and,
• 21.2% had marginal FD(> 4–6.6 ng/mL) with unequal prevalence across the country
Risk groups
• At greatest risk for a folate deficiency are the elderly, women taking birth control pills, long-term antibiotic patients, and alcoholics
• Additionally, evidence is emerging that folatedeficiency may be implicated in the development of deficiency may be implicated in the development of osteoporosis as a result of elevated homosysteine.
• Due to the overwhelming evidence of folacin’simpact on preventing NTD, the FDA is now recommending its food fortification
Folate investigation
• RBC Morphology• Neutrophil segmentation index• Serum folic acid• vitamin B12• vitamin B12• homocysteine
Control and prevention
• Supplementation• Fortification • Dietary diversification• Education• EducationN.B: Vitamin B-12 should always be included in a
folacin supplement program b/c folacinsupplementation can mask an underlying B-12 deficiency
Folate RDA0 - 6 months 6 - 12 months 1 - 3 years 4- 6 years 7- 10 years
25mcg35mcg50mcg75mcg100mcg7- 10 years 100mcg
Females 11-14 years15+ years
150mcg 1 80mcg
Pregnant 400mcg