TRANSBIO. Oportunidades de negocio y nuevas fuentes de ingreso

BioTRANSformation of by-products from fruit and vegetable processing industry into valuable

BIOproducts

This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 289603

BRUNO SOMMER FERREIRACEO – BIOTREND SA

Vitoria-Gasteiz, 03-11-2015Biotrend SA Slide 0

Presentation outline

- Industrial Biotechnology

- Bio-based economy

- Feedstock

- Beyond 1st generation

- Biorefinery concept

- Examples

- About Biotrend



Industrial biotechnology

Food additives

BiopolymersRenewableresources

Micro-organisms

IndustrialBiotechnology

Fuels & Chemicals

And more, much more…

A plethora of products:




Starch

Lignin

Oil

Protein

Biomass Feedstocks

Intermediate Platforms

Building Blocks

Products/Uses

Biobased Syn Gas

Sugars Glucose Fructose Xylose Arabinose Lactose Sucrose Starch

Ethanol Glycerol Lactic acid Succinic acid Fumaric acid Propionic acid Malic acid Furfural Aspartic acid Glucaric acid Glutamic acid Itaconic acid Levulinic acid Malic acid Hydroxy propionic acid Sorbitol Xylitol Arabinitol

Textiles Carpets, Fibers, fabrics, fabric coatings, foam cushions, upholstery, drapes, lycra, spandex

Safe Food Supply Food packaging, preservatives, fertilizers, pesticides, beverage bottles, appliances, beverage can coatings, vitamins

Transportation Fuels, oxygenates, anti-freeze, wiper fluids molded plastics, car seats, belts hoses, bumpers, corrosion inhibitors

Housing Paints, resins, siding, insulation, cements, coatings, varnishes, flame retardents, adhesives, carpeting

Recreation Footgear, protective equipment, camera and film, bicycle parts & tires, wet suits, CD’s, DVD’s, golf equipment, camping gear, boats

Health and Hygiene Plastic eyeglasses, cosmetics, detergents, pharmaceuticals, suntan lotion, medical-dental products, disinfectants, aspirin

Environment Water chemicals, flocculants, chelators, cleaners and detergents

Communication Molded plastics, computer casings, optical fiber coatings, liquid crystal displays, pens, pencils, inks, dyes, paper products

Industrial Corrosion inhibitors, dust control, boiler water treatment, gas purification, emission abatement, specialty lubricants, hoses, seals

Sec chemicals

Intermediates

Cellulose

Hemicellulose

Olefins Diacids Esters Dilactide Acrylate PDO BDO Furane THF Caprolactam Carnitine Phenolics

Methanol

Ether

Direct polymers

Fuel additives Solvents Emulsifiers Polymers Resins




0

1

2

3

4

1983 1986 1989 1992 1995 1998 2001 2004 2007 2010 2013*

Sugar Wheat Corn Soybean oil Palm oil Crude oil

Drivers for adoption

- Reduce dependence on oil-derived raw-materials;

- Use renewable resources;

- Reduce use of water

- Lower energy consumption and CO2 emissions.




Drivers for adoption

Balance between use and generation of carbon-rich resources



Bio-based economy

World chemicals market, excluding pharma: 3000 billion USD/yearBio-based share of chemicals market (USDA, 2008)

R&D expenditures vs. future markets (OECD, 2009)

!!

0%

10%

20%

30%

2005 2010 2025

Biobased Share



Bio-based economy

Global renewable chemicals and materials market to be approximately $2.5 billion (~1.2 million metric tons) in 2012, excluding oleochemicals

Price: ~$2/kg mostly high-volume, low value products (mainly biofuels)



Bio-based economy



Bio-based economy

,814

,927

1,019

Bio-basedbulkchemicals

Other bulkchemicals

2017

1.132

113

2012

960

342007

826

12

CAGR(2012-17F)

27.5%

€ B

1.9%

Bulk chem icals m arket Specialty chem icals m arket

€ B

CAGR(2012-17F)

17.5%

4.5%

,494

,622

,776

2012

692

70

Bio-basedspecialtychemicals

Otherspecialtychemicals

2017

934

157

2007

521

26

Source: G. Festel (EFIB 2009, OECD 2010)



Bio-based economy

Sources: Research and Markets, 2013; Transparency Research, 2013

Specialty Area CAGR (%)

Biopolymers 14.3

Synthetic lubricants 2.5

Bioplastics 24.3

Biosurfactants 3.5



Bio-based economy

20

Substitutes • PLA, starch‐ based plastics

“Drop‐in” Replacements • PE, PP, PET, solvents, polymers

Improvements • Spider silk, living materials

Butanol

Adipic acid Isoprene

Succinic acid

Terephthalic acid Butadiene

BDO

PDO

Acrylic acid

Furans



Bio-based economy



Feedstock



Beyond 1st generation

Many sources are underutilized:Wood, agro-waste, manure, household waste, wastewater sludge, industrial waste.

Challenge:transform complex andheterogeneous materialsinto usable industrialraw materials.

€ 0-50/ton

> €400/ton

€0-50/ton



13

First generation feedstocks • Corn, cane, vegetable oils

Cellulosic materials • Bagasse, corn stover, woody biomass

Waste feedstocks • MSW, CO2, flue gas

Pro: commercially available, existing supply chains today, easy to convert Con: competes with food; price volatility

Pro: low cost; sometimes collected/aggregated; doesn’t compete with food Con: difficult to release sugars; high capital cost conversion; often left in field

Pro: negative cost today; doesn’t compete with food or agriculture; available near fuel demand Con: heterogeneous; costs likely rising; impurities; difficult to convert





17.5%75% RESIDUES LEFT ON FIELD

5% HUSBANDRY2.5% POWER

914 million tons of residues will be availablein eight selected regions

2030 figuresagriculturalresidues only

Source: Bloom berg New Energy Finance, “Moving towards a next -generat ion ethanol economy” 2012



Biorefinery concept

fuel

Source: Arlan Peters, WCIB 2014, Philadelphia.



Potential raw-materials

Lignocellulosic residues- agriculture- forestry

Cheese whey

Glycerol- by-product of biodiesel

Wastewater sludge



Transbio’s contribution



Lignocellulosic residues for PHA



Lignocellulosic residues for PLA

Polymeriza on Fermenta on

Con nuous opera on is possible. The monomer is a erwards polymerized into PLA.

Cell‐free stream towards lac c acid

purifica on Lignocellulosic hydrolysate

sugars

Cell recycle

Micro or ultra‐filtra on membrane

Frac ona on Photosynthesis

Free carbon (CO2)

Plant biomass

Sugar frac on

Purifica on

Fermenta on broth

Bio‐based monomer Biopolymer



Lignocellulosic residues for PLA

Source; Hans van der Pol, WCIB 2014,

Philadelphia



Lignocellulosic residues for PE



Cheese whey

Regional market dynamics matters.Whey was a huge problem in Europe a decade ago. Today there is shortage of whey.



Crude glycerol



Wastewater sludge

- Food waste- Olive and palm oil mills effluents- Diary effluent- Paper mill effluents- Fruit and tomato cannery effluents- Brewery effluent- Municipal wastewaters

Open, mixed cultures.



Development - Building blocks

Source: Bonaire Le,July 10, 2014(Nexant Blogs)



Building blocks

Source: Babette Petersen, WCIB 2014, Philadelphia.



Integration



Biotrend

Bioprocesses for a sustainable and profitable industry



Highly qualified and experienced team• Staff with international experience

(Portugal, The Netherlands, Canada, France, Germany, Switzerland)

State‐of‐the‐art facilities• Process development, optimization, integration• Process scale-up, de-risking and validation

(2-250L and beyond)



Biotrend

Example projects for clients

Large pulp and paper company, world leader in premium office paper:Fermentation-based valorization of carbon-rich liquid waste streams from pulp and paper mills.

Leading confectionery multinational and leading plastics research institute:Deconstruction and transformation of carbohydrate-rich solid residues into materials suitable for packaging applications.

Innovative enzyme engineering company: Increase the productivity and reduce the cost of the production of the enzyme.

Marine biotech start-up: Increase the yield and productivity of the production of cell extracts with cosmetic use.

Beverage company: Increase the robustness and scale-up of the production of an innovative fermented beverage.



• Ex. Marine bacteria extract production

Process intensification Improve the economics of the process

0

10

20

30

40

50

60

0 20 40 60

Prod

ucon

(OD

units)

Time (h)

Client

Biotrend 1

Biotrend 2

Clients: from small start‐ups to multi‐billion USD multinationals



0

100

200

300

400

500

0 10 20 30 40

Prod

uct (AU

)

Time (h)

Client

Biotrend‐1

Biotrend‐2

Biotrend‐3

Process intensification Improve the economics of the process• Ex. Industrial enzyme production

Clients: from small start‐ups to multi‐billion USD multinationals

€1300 /AU

€200 /AU



Biotrend

Collaborative R&D

At the forefront of scientific development• 7 EU co-funded large collaborative projects with partners across the industrial

biotechnology value chain (~3 million USD)• 49 companies

• 29 universities and RTDs

• 25 countries, 3 continents



Biotrend

Contacts:

Bruno Sommer Ferreira+351 231 410 [email protected]

