POINTS ABOUT

DRUGS medpgnotes

POINTS ABOUT DRUGS

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1

Contents ANTICHOLINESTERASE .................................................................................................................................................................................................................................. 2

AUTACOIDS .......................................................................................................................................................................................................................................................... 2

BETA BLOCKERS ................................................................................................................................................................................................................................................ 2

BISPHOSPHONATES ......................................................................................................................................................................................................................................... 2

CATARACT NUGGETS ....................................................................................................................................................................................................................................... 3

CONDITION AND SPECIFIC DRUG ............................................................................................................................................................................................................... 4

CONDITION AND SPECIFIC SURGERY ....................................................................................................................................................................................................... 5

DIABETES NUGGETS ........................................................................................................................................................................................................................................ 6

DIFFERENT USAGE OF DRUGS ..................................................................................................................................................................................................................... 7

DRUG OF CHOICE ............................................................................................................................................................................................................................................... 7

DRUG KINETICS ............................................................................................................................................................................................................................................... 11

FEW DRUG INTERACTIONS ........................................................................................................................................................................................................................ 11

MECHANISM OF ACTION OF DRUGS ....................................................................................................................................................................................................... 12

MONOCLONAL ANTIBODIES ...................................................................................................................................................................................................................... 19

NITRATES NUGGET ....................................................................................................................................................................................................................................... 19

OPIOID NUGGET .............................................................................................................................................................................................................................................. 20

PRODRUGS ........................................................................................................................................................................................................................................................ 20

SAFEST DRUGS IN PREGNANCY NUGGET ............................................................................................................................................................................................. 21

STEROID DRUGS ............................................................................................................................................................................................................................................. 21

TREATMENT OF CHOICE ............................................................................................................................................................................................................................. 22

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2 ANTICHOLINESTERASE

ANTICHOLINESTERASE Naturally occurring Anticholinesterase Lipid Soluble Anticholinesterase Blood brain barrier crossing Anticholinesterase

Physostigmine

Anticholinesterase used in Myasthenia Gravis Neostigmine/Pyridostigmine

Anticholinesterase used for Diagnosis of Mtasthenia Gravis

Edrophonium

Anticancer showing Anticholinesterase Property Irinotecan

AUTACOIDS FUNCTION AUTAOIDS

Most Important chemical elevating Hypothalamic setpoint

PGE2

Vasoconstrictor PGF2

Prostaglandins causing Renal Vasodilataion PGI2,PGE2

Vasodilatation in blood vessels PGI2,PGE2,PGF2α

Platelet Aggregation TXA2

Inhibition of Platelet aggregation PGI2

Chemotactic LTB4

Bronchoconstrictor Slow reacting substance of anaphylaxis(SRSA)

LTC4 LTD4 LTE4

BETA BLOCKERS Most Cardioselective Vasodilator Property

Nebivolol

K+ Blocking Property Sotalol

K+ Opening Property Tilsolol

Selective β2 blocker Butoxamine

Non Catecholamine acting selectively on β Prenalterenol

BISPHOSPHONATES 1

st Bisphosphonate Approved Etindronate

Treatment of Postmenopausal Osteoporosis Alendronate Risendronate

Prevention of Steroid Induced Osteoporosis Risendronate

Unique Administration Technique Once Yearly i.v/Once Monthly Oral

Zolendronate Idandronate

Most Potent Drug for Treatment & Prevention of Osteoporosis

Bisphosphonates

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3 CATARACT NUGGETS

CATARACT NUGGETS Anterior Polar Perforation of corneal ulcer

Anterior Capsular Vossious ring

Anterior Subscapular Glaucoma

Posterior Polar Mittendorf dot

Posterior Capsular

Posterior Subcapsular Steroid

MC cause of blindness in India Cataract

MC cause of blindness in Adults Cataract

MC cause of blindness in children Keratomalacia

MC cause of cataract Age Related

MC Type of Congenital Cataract Punctate cataract

MC Health Disorder among Geriatrics Visual Impairment/Cataract

MC visually significant Congenital cataract Lamellar/Zonular cataract

Lens changes in Anterior Uveitis Complicated Cataract with Posterior Capsular Opacities

Second Sight Nuclear Cataract

Fluctuation of Refractory Error Diabetic Cataract

Complication of Intumescent Cataract Phacomorphic Glaucoma

Complication of Morgagnian cataract Phacolytic Glaucoma

Complication of Hypermature Sclerotic Cataract Subluxation/Dislocation of Lens Phacoanaphylactic Uveitis

Cataract in Galactosemia is due to accumulation of Galactitiol

Cataract in Diabetes due to accumulation of Sorbitol

Galactosemia Oil Drop Cataract

MC Ocular Complication of Systemic Steroid Cataract

SPECIFIC CATARACT

Snow Flake Cataract Diabetes Mellitus

Sunflower Cataract Wilson’s disease Chalcosis Penetrating trauma

Vossious ring on anterior surface of lens Rossette Shaped Cataract

Blunt Trauma

Christmas Tree cataract Myotonica Dystrophica

Oil drop Cataract Galactosemia

Morgagnian Cataract Hypermature Senile Cataract

Rainbow cataract Breadcrumb Cataract Polychromatic Lusture

Complicated Cataract

Snow Blindness Ultraviolet

Glass Blower’s Cataract Infrared