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MahatmaGandhiUniversity,Kottayam

M.SC.DEGREE(CSS)EXAMINATION,APRIL2010

SecondSemester

FacultyofSciences,BranchVI‐Botany

PC8–GENETICSANDBIOCHEMISTRY

(2012Admissiononwards)

Time:ThreeHours MaximumWeight:30

I. Answeranysixofthefollowinginnotlessthan50words.Weight1each1. Differentiatebetweennon‐competitiveanduncompetitiveinhibition2. Whatisstrainanddistortiontheory?3. Explainthefollowing:‐

a. Penetranceb. Polygenesc. Oncogenesd. Interference

4. WhatisHardy‐Weinberglaw?5. Describethefollowing:‐

a. Allostericinhibitionb. Biotinc. Proteoglycand. Kw

6. Nameanytwosulfurcontainingaminoacid.7. Whatareessentialfattyacids?8. WhatisRamachandranplot?

II. Answeranysevenofthefollowinginnotlessthan100words.Weight2each9. Explainthefollowing:

a. Geneticpolymorphismb. SimpleQTc. Over‐dominanced. Centi‐morgan

10. Brieflyexplainthestructureandfunctionsofmembranelipids11. Explaingeneticmappinginhumanpedigrees.12. Explainthefollowing:

a. Acid‐basecatalysiswww.easy

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b. pKac. Activatord. ATP

13. Writeanoteonforcesthatstabilizetertiarystructureofproteins14. Explaintheclassificationofaminoacidsbasedonpolarity.15. Describedifferentmechanismsofsexdeterminationinanimals?16. Brieflyexplainthebiosynthesisofalkaloids17. Whataretumorsuppressorgenesandhowdotheycheckthegrowthofcancerous

cellsinnormaltissuesandallowtheuncontrolleddivisioninacanceroustissue?18. Drawthestructureofsucroseandlactose.

III. Answeranytwoofthefollowinginnotlessthan250words.Weight5each19. BrieflyexplainMichaelis‐Mentonconstantanditskinetics.Addanoteonthe

significanceofLineweaver‐Burkplotinenzymekinetics.20. Giveanaccountoffactorsthatalterallelicfrequenciesinapopulation.21. Describesynthesisofpurinenucleotidesbysalvagepathway.Addanoteon

functionsofnucleotides.

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