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Detecting Viral Infections Using
MicroarraysNacho Caballero
Connor LabWednesday, September 26, 12
RIG-I
Lassa
Wednesday, September 26, 12
RIG-I
Lassa
uninfected
Wednesday, September 26, 12
RIG-I
Lassa
uninfected
1.30
-0.74
Wednesday, September 26, 12
RIG-I
Lassa
uninfected
3 dpi
1.10
2.83
1.30
-0.74
Wednesday, September 26, 12
RIG-I
Lassa
uninfected
3 dpi
1.10
2.83
1.30
-0.74
Marburg
3 dpi
uninfected
4.72
3.24 4.30
2.37
Wednesday, September 26, 12
Wednesday, September 26, 12
uninfected-2 dpi 3 dpi-12 dpi
Wednesday, September 26, 12
uninfected-2 dpi 3 dpi-12 dpi
LassaMarburg
Wednesday, September 26, 12
uninfected-2 dpi 3 dpi-12 dpi
TP34
TN38
FP0
FN0
LassaMarburg
Wednesday, September 26, 12
uninfected-2 dpi 3 dpi-12 dpi
TP34
TN38
FP0
FN0
LassaMarburg
Wednesday, September 26, 12
uninfected-2 dpi 3 dpi-12 dpi
TP34
TN38
FP0
FN0
LassaMarburg
Sensitivity: 1 Specificity: 1
Wednesday, September 26, 12
uninfected-2 dpi 3 dpi-12 dpi
LassaLassa Marburg MarburgTP34
TN53
FP0
FN33
Sensitivity: 0.5 Specificity: 1
LassaMarburgBlind
Wednesday, September 26, 12
uninfected-2 dpi 3 dpi-12 dpi
LassaLassa Marburg MarburgTP38
TN29
FP4
FN6
Sensitivity: 0.86 Specificity: 0.88
LassaMarburgBlind
BlindMarburg
Wednesday, September 26, 12
Next Steps
Wednesday, September 26, 12
Next Steps
Use Agilent v2 microarraysto distinguish between Lassa and Marburg
Wednesday, September 26, 12
Next Steps
Use Agilent v2 microarraysto distinguish between Lassa and Marburg
Use RNA-Seqto identify non-coding RNAsand obtain better resolution of transcriptome
Wednesday, September 26, 12
