IMPLANTABLE POLYMER BASED DELIVERY SYSTEM FOR TAILORED DRUG RELEASE PROFILE

By Tamasree Majumder Reg No. 152772310030 ,1st sem M.Pharm (Pharmaceutics) NSHM Knowledge Campus, Kolkata-Group Of InstitutionsUnder the guidance of Dr. Sutapa Biswas Majee , Associate Professor ,Department of Pharmaceutics,NSHM Knowledge Campus, Kolkata-Group of Institutions

Importance of IDDS

1.Less use of needle2.More patient compliance3.Steady state of drug release4.Site specific drug

administration5.Significantly lower dose of

drug required

TYPES OF IMPLANT BASED DELIVERY SYSTEM

a. Closed loop insulin deviceb. Contraceptive device(IUD)c. Infusion pumpd.Ophthalmic Inserte. Implantable intrathecal pumpf. Osmotic Pump

Closed loop insulin device

• novel glucose-sensitive polymer membrane technology used.• hdrogels are used as

polymers• Presence of bioresponsive

gel• controls tightly fluctuations

in insulin concentrations

-

Marketed formulation:

Marketed formulations Name of company1.  OmniPod® Insulin Management System

Insulet Corp., Bedford, MA

2. Solo™ MicroPump Insulin Delivery System

Medingo US, Inc., Tampa, FL

3. Finesse™ Calibra Medical Inc., Redwood City, CA

4. Cellnovo Pump Cellnovo Ltd., formerly Starbridge Systems, London, UK)

Contraceptive Device (IUD)

1.non-biodegradable polymer used .2.Contain hormonal products generally3.Preload applicator for easier insertion4.Long acting reversible contraception5.Contains Barium sulphate in the drug core to make it detectable by X-Ray

Marketed products of contraceptive implantsMarketed product

Hormones involved

dose Length of duration of action

1.Norplant® Levonorgestrol 75mg 5yrs

2.Nexplanon® Etonogestrol 68mg Upto 3yrs

3.Implanon® Progestin only 68mg Upto 2yrs

Implantable Infusion Pumps

delivers drug to specific site through tubes or catheters

Two types of mechanism- 1.syringe driven and 2.elastrometric pump driven

refilling done by peristaltic repeater pump or through a  a one-way valve using a syringe

Marketed products of some infusion pumps1.PLUM A+ Infusion

Pump2.PLUM 360 Infusion

Pump3.Sapphire Plus Infusion

System4.Sapphire Infusion

System5.Omnipod Insulin

infusion Pump

Ophthalmic insert • substantially pure polymeric

materials are used• mechanism of drug release is

diffusion, bioerosion and osmosis• Natural polymers like collagen

used• synthetic polymers like

HPMC,MC etc are used

Marketed formulations of opthalmic inserts:

Marketed product

Used in diseases Onset of action

Occusert

Lacrisert

Miosis

Kerato conjuctivitis,,keratitis,lachremal sensitivity

Within 10-30mins

Within 20 mins

Implantable intrathecal pump

Battery driven programmable device

used to deliver medication in the spaces between the spinal cord and the protective sheath surrounding the spinal cord

baclofen, morphine, or ziconotide may be delivered

Marketed productsMarketed intrathecal pump

Drug delivered

1. LIORESAL® INTRATHECAL

Baclofen

2. Synchromed II opoid

3. Prometra pump a preservative-free morphine sulfate sterile solution

osmotic pump

Schematic diagram of an osmotic pump A. Driven by osmosisB. Biodegradable in natureC. Can be well explained by the Higuchi ModelD. Plasticizers like dialkyl thalates,sodium benzoates

etc form the formation of the wall forming the osmotic pump

Marketed product of Osmotic Pump

Type of compartment marketed formulation

1.Single compartment LiRIS®, IntelliDrug

2.Bicompartmental ALZET® , Ivomec SR® Bolus , DUROS® ,

3.Multicompartment Acuros

CONCLUSON“Implanted delivery system Shows Promise in Delivering Drugs” - The Wall Street Journal

i. Textbook of Industrial Pharmacy Drug Delivery Systems and Cosmetics and Herbal Drug Technology , Edited by Shova Rani R Heermath , page 81-83

ii. S. Sershen, J. West, Implantable, polymeric systems for modulated drug delivery, Advanced Drug Delivery Reviews 54 (2002); 1225–1235

iii. Karen H. Knight, Frances M. Brand, Ali S. Mchaourab, Giorgio Veneziano , Implantable Intrathecal Pumps for Chronic Pain: Highlights and Updates, Croat Med J. (2007);48:22-34 ,22-25

iv. Mai Nguyen-Misra, Implantable Polymers, Biointerface Conference, 2012 , 31-34

v. Simon Herrlich , Sven Spieth , Stephan Messner , Roland Zengerle , Osmotic micropumps for drug delivery , Advanced Drug Delivery Reviews 64 (2012) 1617–1627.