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What pattern of inheritance does this trait follow?

Genetics pedigree problems

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Page 1: Genetics pedigree problems

What pattern of inheritance does this trait follow?

Page 2: Genetics pedigree problems

Child has trait but parents don’t = recessive

Both males & females have trait = autosomal

Page 3: Genetics pedigree problems

Write in genotypes of individuals to check your guessthat the trait is autosomal recessive

Aa Aa

A_ aa

Autosomal recessive can work if both parents areheterozygous. They won’t show the trait, but child can.

Page 4: Genetics pedigree problems

What pattern of inheritance does this trait follow?

Page 5: Genetics pedigree problems

Both males & females have trait = autosomal

Both parents have trait, but child does not = dominant

Page 6: Genetics pedigree problems

Write in genotypes of individuals to check your guessthat the trait is autosomal dominant

Rr Rr

rr Rr

R_ rr

Page 7: Genetics pedigree problems

What pattern of inheritance does this trait follow?

Page 8: Genetics pedigree problems

Both males & females have trait = autosomalThen take a guess if dominant or recessive.Then write in genotypes to check your guess.

Page 9: Genetics pedigree problems

If you guessed dominant, then red = RR or Rr so write R_ for each red

R_ R_ Rr rr

R_ R_ R_ R_ Rr rr Rr Rr

R_ R_ R_ R_ R_ R_ R_

Dominant works, but does not prove the trait is dominant. You must see if recessive does not work.

Page 10: Genetics pedigree problems

If you guessed recessive, then red = rr

rr rr rr Rr

rr rr rr rr rr Rr rr rr

rr rr rr rr rr rr rr

Recessive also works, so you can not tell how this trait is inherited, from the information given.

Page 11: Genetics pedigree problems

What pattern of inheritance does this trait follow?

Page 12: Genetics pedigree problems

Only or mostly males have trait = sex-linked (x-linked)Children have it, but parents don’t, so recessive

Page 13: Genetics pedigree problems

Write genotypes to test guess of sex-linked recessive

XAY

XaY

XaY

XaY XaYXAX_

XAXa

XAX_

XAX_

Page 14: Genetics pedigree problems

What pattern of inheritance does this trait follow?

Page 15: Genetics pedigree problems

Autosomal dominant because child 9 does not have it but parents 5 & 6 do.

Page 16: Genetics pedigree problems

What are the genotypes of individuals 5 and 6?

Page 17: Genetics pedigree problems

Both have to be heterozygous. They have the trait, but they can passrecessive alleles to their child 9 so she doesn’t have the trait.

Gg Gg

gg

Page 18: Genetics pedigree problems

What is the genotype of individual 9?

What pattern of inheritance does this trait follow?

Page 19: Genetics pedigree problems

Next slide shows the answers

Page 20: Genetics pedigree problems

Individual 9 genotype is As (heterozygous)

Autosomal recessive

Page 21: Genetics pedigree problems

If individuals 5 and 6 had another child, what is the probability of it being affected?

Page 22: Genetics pedigree problems

Next slide shows the answer

Page 23: Genetics pedigree problems

#5 is homozygous recessive aa and #6 is heterozygous Aa, so probability of a child getting aa is ½ or 50%