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Honors Biology class PPt on the process of mitosis; used following DNA
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Cell Division
Cellular Reproduction Organism’s life begins as one cell
Rudolf Virchow (1858) stated: All cells come from cells
Prokaryotes divide only to reproduce
Asexual repro: 1 parent 2 daughters
AKA Binary fission (“dividing in half”)
One set of DNA duplicates, cell divides
Eukaryotic cells divide for reproduction, growth, and replacement of cells
Other organisms (plants & animals especially) reproduce through sexual reproduction
Sperm + Egg
offspring
Offspring gets two
sets of genetic
information, one
from each parent
The Chromosome DNA is contained in structures called chromosomes within the nucleus of the cell
“chroma” color, “soma” body
Most of the time, chromatin fills the nucleus
Tangled mass of fibers of DNA & protein
When a cell begins to divide, the chromatin condenses and coils into chromosomes
Each chromosome has one long DNA molecule containing thousands of genes
The Chromosome Before a cell divides, it must duplicate its chromosomes
DNA replication!
Once duplicated, the chromosomes have sister chromatids with identical genes, joined at a centromere
When the cell divides, half goes to each daughter cell
The Cell Cycle Sequence of events from the time a cell divides to when it forms two daughter cells
Serves to double the cell’s parts, then splits
Stages:
Interphase 90%
Mitotic phase 10%
Mitotic Phase Unique to eukaryotes
Ends with 2 identical cells
Sub-stages of Mitosis:
Prophase
Metaphase
Anaphase
Telophase
Cytokenisis
Prophase Sister chromatids are attached at centromere
Centrioles separate and extend spindle fibers
Nucleolus disappears and nuclear envelope breaks down
Kinetochores form on each chromatid, spindle fibers attach
Metaphase Centrosomes at poles
Chromosomes lined up at metaphase plate (cell’s equator)
Kinetochores of sister chromatids face opposite poles
Anaphase Spindle fibers pull sister chromatids apart forming daughter chromosomes
Chromosomes move centromere first towards opposite poles
Cell elongates
Telophase & Cytokenisis
Cell continues to elongate
Daughter nuclei appear at poles
Nuclear envelopes reform
Spindle fibers disappear
Cytoplasms separate, new cell membranes form
Cytokenisis Cell pinches into two cells
Called a cleavage furrow
Plants are a little different
Vesicles save materials from cell wall
Form a plate at center of dividing cell
Cell plate fuses to cell wall, 2 cells
Factors that Affect Cell Division
Most reasons are unknown
“Growth Factors”
Proteins need for division; if not present it stops
Cell-cycle control system
A system of proteins in the cell that trigger & coordinates major events in the cell cycle
Make checkpoints
Factors that Affect Cell Division
Anchorage dependence
Cells must be in contact with a solid surface
Density-dependant inhibition Division will slow as the population grows more dense
When It All Goes Wrong Cell-cycle control system malfunctions
Cells divide excessively and in the wrong places; creates tumors
Benign: normal cells
Malignant: cancerous, invasive
Will divide indefinitely if not treated
When It All Goes Wrong Types of Cancers
Carcinoma
Skin, stomach lining
Sarcoma
Supporting tissues, bones
Leukemia & Lymphoma
Blood producing tissues, bone marrow
Treatments Aim to stop the spread of cancerous cells by stopping division
Chemotherapy (meds) and/or Radiation