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Project – Brain Simulator
Speaker : Tony TsengAdvisor : Hsing Mei
Web Computing LaboratoryComputer Science and Information Engineering
Department Fu Jen Catholic University
May 1st, 2010
210:56
Outline
• Introduction• Brain Network• The Theory of Neuronal Group
Selection• Case Study - Alzheimer's disease• Ideas of Brain Simulator• Conclusion and Future Work
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
310:56
Introduction
• Web Intelligence• Understand Human Intelligence• Brain Informatics• Simulate Brain Models for new Web
Intelligence
Step One• Brain Simulator
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
410:56
Brain Network
• Thalamo-cortical motif• Polysynaptic loop structure• Diffuse ascending projections
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
510:56
Thalamo-cortical motif
• Thalamocortical radiations– Directions
• Thalamus – Cortex• Cortex – Cortex• Cortex – Thalamus
– Reentrant mapping– Small World Network
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
from Edelman & Tononi, 2000
610:56
Diffuse ascending projections
• Value System• Neurotransmitters
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
from Edelman & Tononi, 2000
710:56
The Theory of Neuronal Group Selection
• Developmental Selection– The formation during brain development– Neurons fire together wire together
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
from Edelman & Tononi, 2000
810:56
The Theory of Neuronal Group Selection
• Experiential Selection– Synaptic selection– Refining brain maps into internal
representations
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
from Edelman & Tononi, 2000
910:56
The Theory of Neuronal Group Selection
• Reentrant Mapping– This is the process of neuronal
integration– The thalamo-cortical system
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
from Edelman & Tononi, 2000
1010:56
Case Study - Alzheimer's disease
• The most common form of dementia• Affect 1 in 85 people globally by
2050• Causes
– Tangles– Plaques
– The neurotransmitter acetylcholineWECO Lab, CSIE Dept., FJU
http://www.weco.net
from AHAF
1110:56
Case Study - Alzheimer's disease
• Comparison of a normal aged brain (left) and an Alzheimer's patient's brain (right)
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
from wikipedia
1210:56
Case Study - Alzheimer's disease
• The acetylcholine pathway
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
from thebrain
1310:56
Ideas of Brain Simulator
fMRI
Data
Brain
Simulator
Analysis
Tools•Pajek• WEK
A• Matl
ab
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
1410:56
Ideas of Brain Simulator
• Macro (Global)– Dynamic Core
• Spatial• Temporal
– Integration of Brian Maps• Mesco (Intermediate)
– Neural Migration– Degeneracy
• Micro (Local)– Neurogenesis– Synaptogenesis / Synaptic Prunning– Myelination
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
1510:56
Ideas of Brain Simulator
• Analysis of Brain Simulator• Simulate Brain Models for new Web
Intelligence
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
1610:56
Conclusion and Future Work
• Brain Network• TNGS• Ideas of Brain Simulator• Future Work
– Polysynaptic loop structure– Results of AD related experiments– Modeling our brain simulator– Brain-Oriented SLS
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
1710:56
~END~THANK YOU
WECO Lab, CSIE Dept., FJUhttp://www.weco.net
