PowerPoint Presentation

Biomaterials in Bone Regeneration

Presented byM R Khan

Bone is a dynamic and highly vascularized tissue that continues to remodel throughout the lifetime. It plays an integral role in locomotion, load-bearing capacity, and acts as a protective casing for the internal organs of the body.Current challenges include the engineering of materials that can match both the mechanical and biological context of real bone tissue matrix and support the vascularization of large tissue constructs.Scaffolds with new levels of biofunctionality that attempt to recreate nanoscale topographical and biofactor cues from the extracellular environment are emerging as interesting candidate biomimetic materials.Introduction

The gold standard for reconstruction of large bone defects is the use of Autogenous bone grafts, Allografts or synthetic grafting, Alloplastic. But this method lack of sufficient transplantable materials, donor site morbidity, inflammation, and resorption of the implanted bone.

The current therapies for bone regeneration and perspectives in the field of stem cell-based regenerative medicine addressing sources of stem cells and growth factors to develop an efficient and high-quality bone derivation without any immunorejection and tumorigenesis.Introduction

Biological concept of using bone regenerationContains bone forming cell (osteogenesis))Serve as scaffold for bone formation (osteoconduction)Matrix of bone regeneration materials contains bone inductive substance (osteoinduction)OsteoinductionOsteogenesis

Bioactive Inorganic MaterialsTricalcium PhosphateCalcium PhosphatesHydroyapatite (HA)Bioactive GlassesTheir CombinationsPolymersBiological PolymersCollagenHyaluronic AcidSynthetic PolymersPoly-hydroxylethyl-methacrylate (PHEMA)PolyfumaratesPolylactic Acid (PLA)Polyglycolic Acid (PGA)Co-polymers Of PLA And PGA (PLGA)Polycaprolactone

Biomaterials Bone Regenaration

Biomaterials Bone Regenaration

Enhancing material biofunctionality. Control over cellular interaction for bone and cartilage repair can be achieved through scaffold material design.

How to Work Biomaterials in Bone Regeneration

The End