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(c) Geromil J. Lara, RMT, MSMT
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BIOENERGETICS – Part 2HOW THE BODY CONVERTS FOOD TO ENERGY
Geromil J. Lara, RMT, MSMT
GLUCONEOGENESIS
• Production of glucose from non-carbohydrate sources– Lactate – All amino acids except leucine and lysine– Glycerol from fats
• Amino acids and glycerol are used only under starvation conditions
• Occurs primarily in the liver
CORI CYCLE
GLYCOGENESIS
• Formation of glycogen from glucose
• Occurs in the liver
• Influenced by insulin – Inhibits glycogen phosphorylase– Stimulates glycogen synthase and
glucokinase
GLYCOGENOLYSIS
• Breakdown of stored glycogen to form glucose
• Influenced generally by glucagon and epinephrine in response to low blood glucose levels
• Glycogen phosphorylase is activated• Glycogen synthase is inhibited
(2) CITRIC ACID CYCLE
• Also known as the Kreb’s Cycle• Final stage of the breakdown of
carbohydrates, fats, and amino acids.
• Series of enzymes involved
KETONES
• Formed from beta-oxidation pathway of fatty acid metabolism due to low level of glucose (starvation and fasting)
• Low glucose supply slows down citric acid cycle– No glycolysis– No PEP production– Greatly reduced oxaloacetate production
• As a result, acetyl CoA builds up in the body
(3) OXIDATIVE PHOSPHORYLATION
• Is a series of reactions which couples the oxidation of NADH and FADH2 to the phosphorylation of ADP to generate ATP
• NADH = used to produce 3 ATPs• FADH2 = used to produce 2 ATPs
NUMBER OF ATP PRODUCED BY THE COMPLETE OXIDATION OF ONE MOLECULE
OF GLUCOSEGlycolysis
– Substrate-level Phosphorylation 2 ATP– 2 NADH x 2 ATP/cytoplasmic NADH 4
ATP
Conversion of 2 pyruvate molecules to 2 acetyl CoA molecules– 2 NADH x 3 ATP/NADH 6 ATP
Citric Acid Cycle– 2 GTP x 1 ATP/GTP 2 ATP– 6 NADH x 3 ATP/NADH 18 ATP– 2 FADH2 x 2 ATP/FADH2 4
ATP
CATABOLISM OF THE NITROGEN OF AMINO ACIDS
• Dietary proteins are hydrolyzed to amino acids in digestion
• Amino acids are primarily used to synthesize new proteins
• Cannot be stored, so excess amino acids are catabolized for energy production in the liver1. Transamination
2. Oxidative Deamination
3. Urea Cycle
TRANSAMINATION
• Amino acids transfer their amino group to alpha-ketoglutarate
OXIDATIVE DEAMINATION
• Oxidative deamination of glutamate
UREA CYCLE
• Ammonia is converted to urea
CATABOLISM OF HEME
• Red Blood Cells– 80 – 120 days life span– Destroyed by the phagocytic cells– Hemoglobin is metabolized
• Globin is hydrolyzed to amino acids• Heme is oxidized to biliverdin and
finally reduced to bilirubin• Bilirubin enters the liver• Iron is preserved in ferritin and reused
NEXT ON BIOCHEMISTRYNUTRITION: AN INTRODUCTION