APLA SYNDROME

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  • 1. APLA SYNDROME - Anti Phospholipid Antibody SyndromeMyriad Presentation Dr.AnitaDr.K.S.V.Chalam,Dr.A.Lalitha,Dr.A.P.Naveen Kumar,Dr.D.V.N.Sharma, Dr. M.K.Tripathy

2. Polyarthritis and rash Gangrene of tips of fingers Treated with LMWH and then acitrom Recovered completely ANA , DsDNA , Anti Cardiolipin positive On follow up 3. 28 yr. female Recurrent abortions Anti cardiolipin antibodies positive Started on anticoagulants Delivered a female baby with LMWH 4. ACA SYNDROME 5. 34 yr. female Polyarthritis and skin rash Developed swelling of leg Doppler showed DVT ANA,DsDNA,Smith and Anti cardiolipin Ab.positive 6. Presented with septicemia and MODS Recovered completely except for thrombocytopenia ANA positive treated with steroids After 1 yr. developed swelling of abdomen U/S s/o Budd Chiari Investigations confirmed APLA 7. 12 yr. girl Recurrent abdominal pain Confirmed as pancreatitis Later symptoms of rash and arthritis Investigations for SLE and APLA positive On immunomodulants and acitrom Developed CNS lupus and recovered 8. Presented with convulsions MRI brain large bleed Thrombocytopenia MR Venogram Sup. Saggital sinus thrombosis APLA workup positive