Ap Bio Collagen (Masiello)

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Collagen and its wonderful ways

Text of Ap Bio Collagen (Masiello)

  • 1. Collagen
    Natures Favorite Protein

2. Did you Know?
Collagen is the most abundant protein found in mammals, accounting for roughly 25% of the protein content.
It is, pretty much, connective tissue and is found in many parts of the body including
3. Blood
4. Teeth
5. Skin
6. And Blood Vessels
7. WOW!!!!!!!!!!!
8. What It looks like
9. Size and Structure
The tropocollagen or "collagen molecule, as one might say, is a subunit of larger collagen aggregates such as fibrils. It is approximately 300nm long and 1.5nm in diameter, made up of three polypeptide strands, alpha chains as what that same person might also say, each possessing the conformation of a left handed helix. These three left-handed helices are twisted together into a right handed coiled coil, a triple helix or super helix according to that very same person, a cooperative quaternary structure stabilized by numerous hydrogen bonds.
10. Five types of collagen account for 90% found in thebody
Collagen One: skin, tendon, vascular, ligature, organs, bone (main component of bone)
Collagen Two: cartilage (main component of cartilage)
Collagen Three: reticulate (main component of reticular fibers), commonly found alongside type I.
Collagen Four: forms bases of cell basement membrane
Collagen Five: Cells surfaces, hair and placenta
11. Disorders
Brittle Bone disease (Osteogenesis imperfecta): a deficiency of type I collagen
EDS (Ehlers-Danlos syndrome):
Lows- loose, unstable joints, Flat Feet, and low muscle tone
Highs- velvety smooth skin, SUPER flexibility (like Mr. Fantasticalmost)
12. He Truly is Fantastic
13. Intrigue
When collagen (from say cow tendons or horse ligaments) is heated, it looses all of its structure. The triple helix unwinds and the chains separate. When this denatured mass of tangled chains cools, they absorb the surrounding water to form gelatin.
14. Scurvy
Hydroxyproline, which is oh so critical for collagen stability, is created by modifying normal proline amino acids after the collagen chain is built. The reaction requires vitamin C to assist in the addition of oxygen. Vitamin C deficiency slows the production of hydroxyproline and stops the construction of new collagen, ultimately causing scurvy. The symptoms of scurvy--loss of teeth and easy bruising-- are caused by the lack of collagen to repair the wear-and-tear caused by everyday activities.
15. Every third amino acid is a glycine, and many of the remaining amino acids are proline or hydroxyproline.
16. Without
Means scurvy