Upload
subbu-raj
View
632
Download
0
Tags:
Embed Size (px)
Citation preview
ALCOHOL BASICS PROF.DR .ELANGOVAN’S UNIT
D.SUBBURAJ
EPIDEMIOLOGY
• MC substance abuse in INDIA -ALCOHOL– NEXT MC- CANNABIS
• South india prevalance -33—55%• Highest alcohol consumption -- KERALA
– 8 L / CAPITA• WORLD WIDE—LUXEMBOURG (15.5 L)
ALCOHOL
1 unit=10gm=12.5 ml absolute alcohol=1 drink• Can’t be stored in the body• Energy -7 kcal gm• Some amount of other nutrients
– some potassium ; no sodium– Riboflavin & niacin– Possible antioxidant benefits from
polyphenols(?)– sometimes VIT C
STANDARD DRINK
• any drink that contains about 14gmOf absolute alcohol
AUSTRIA 6 gm
U k 8 gm
AUSTRLIA 10 gm
FINLAND 11 gm
CANADA 13.6 gm
U S 14 gm
JAPAN 19.75 gm
STANDARD DRINK
Beer 4 – 8 %
Vodkas 40.0 - 50.0 Wines 7– 22 %Gin 40.0 - 48.5
Rum 40.0 - 95.0 Whiskies 40.0 - 75.0 Brandies 40.0 - 43.0
BINGE DRINK
• U S DEFINITION– Consumption of five or more standard drink by
males , four or more by females in about 2 hrs• U K DEFINITION
– Drinking more than twice the daily limit (>8 men, >6 women)
• NIAAA DEFINITION– Any time one reaches a peak BAC of 0.08% or
higher
SAFE DRINK
• no uniform guidelines• UK– 2-3 standard drink daily or 14 per week• USA– 1 standard drink daily or 7 per week• Not more than 3 drinks on any one occasion• Don’t drive or engage in hazardous activities• Don’t drink if an interacting drug has been
taken
Where does Alcohol come from?
Grain whisky and beer
Sugar rum
Honey mead
Apples cider
Grapes wine and brandy
Potatoes vodka
COCK TAIL DRINK K J1 glass stout (250 ml) 570
1 glass beer (250 ml) 380
1 Glass white wine (100 ml) 280
1 Glass red wine (280 ml) 280
1 Nip of spirit 40% (30 ml ) 250
1 Glass mixer (440 ml) 440
1 Glass diet mixer (250 ml) 5
13
14
Graph source: National Institue on Alcohol Abuse and Alcoholism
Factors that influence absorption
• Gender– Women produce less of enzyme needed to breakdown
alcohol– Women have greater fat content and alcohol is not fat
soluble so it enters the blood stream faster– Women have less water so alcohol does not become
diluted– Women absorb more alcohol during the premenstrual
phase
• Absorption increased by – Rapid gastric emptying ( carbonated beverages)– Absence of meal– Absence of congener– Dilution
• Tissue distribution - blood flow & water content
• Obese persons & women- higher BAC• Follows zero – order kinetics • So metabolism doesn’t vary widely in the
population
MEOS- microsomal ethanol oxidizing system -CYP2E1
3-pathways of EtOH metabolism
ADH in stomach (males) ADH & MEOS in liver (males &
females)
Catalase in liver (males & females)
ETHANOL
CATALASE ADH MEOS
ACETALDEHYDE
ALDH MITOCHONDRIA ACETATE
EXTRA HEPATIC TISSUES
Microsomal Ethanol Oxidizing System (MEOS)
• Alternate pathway used, in addition to ADH, when alcohol intake is excessive
• End products include:– Ethanol acetaldehyde– NADPH + H+ NADP+
No ATP formation = Energy Wasteful• Also involved in drug metabolism
– Excess ethanol- less MEOS for drug- drug overdosage
Genetic Variation
•50% of Asians have inactive ALDH•Develop flushing reaction•Acetaldehyde Dehydrogenase (ALDH) varies in Caucasians, Blacks and Asians.• poly morphism TNF PROMOTER - susceptible to alcoholic steatohepatitis•Alcoholism -inherited ; specific gene not identified
Metabolic effects
• High NADH/NAD RATIO– Prevents pyruvate entering in to
gluconeogenesis- HYPOGLYCEMIA– Converts pyruvate to lactate - acidosis-
uricacidaemia- GOUT– Increase TG - FATTY LIVER
• INDUCES DRUG METABOLISM• FREE RADICAL FORMATION• ACCUMALATION OF ACETALDEHYDE
POSSIBLE HEPATO TOXIC EFFECTS OF ACETALDEHYDE
• Increase lipid peroxidation • Binds plasma membrane• Interferes with mitochondrial electron
transport chain • Inhibits nuclear repair• Interferes with microtubule formation• Activates complement• Increases collagen synthesis
DRUG INTERACTIONS
• Synergies with anxiolytics, antidepressants, antihistamines, hypnotics, opioids-- marked CNS depression with motor impairment -- chances of accidents increase
• Insulin & sulfonylureas: enhances hypoglycaemia• Aspirin & other NSAID –gastric bleeding• Parcetamol toxicity• Acute alcohol ingestion inhibits , chronic
alcoholism enhances phenytoin metabolism
Disulfiram like reaction• irreversible ALDH inhibitor- acetaldehyde
accumulates flushing reaction
DIAGNOSIS OF ALCOLISM
• TOLERANCE– A state of adaptation in which increasing amounts of
alcohol are needed to produce desired effects• PHYSICAL DEPENDENCE
– A typical withdrawal syn appears on interruption of drinking , which is relieved by alcohol itself or other drugs
• IMPAIRED CONTROL– Total alcohol intake cannot invariably be regulated , once
drinking has begun at any drinking occasion• CRAVING
– A dysphoria of abstinence that leads to relapse
Causes of Alcoholism
• Genetics– Strong family link– 50% of fathers, sons, brothers of alcoholics are likely to
become alcoholics– Children of alcoholics are more then 3-4 times more likely
to become alcoholics
• Personality types– Low self esteem– Chronic anxiety– Antisocial personalities
QUESTONNAIRES
• CAGE ( cut down , annoyed ,guilty, eye-opener)
• MAST (michigan alcoholism screening test)• AUDIT ( alcohol use disorder identification
test)• RAPS4 (rapid alcohol problems screen 4)• QFS ( quantity frequency score)
CAGE QUESTIONARE
• Have you ever felt to cut down?• Have people annoyed you by criticizing ?• Have you ever felt guilty or bad ?• Have you ever had a drink first thing in the
morning to steady your nerves or to get ride of hang over? (eye opener)
One ‘yes’ – suspicion More than one-alcohol abuse or dependance
CLINICAL COURSE
• Age at first drink 13—15 yrs
• Age at first intoxication 15—17 yrs• Age at first problem 16—22 yrs• Age at onset of dependence 23---40 yrs• Age at death 60 yrs
• Spontaneous remission in 20% Same as general population.
DSM-IV CRITERIAS
• ALCOHOL ABUSE• Recurrent use of alcohol associated with any
one of the following with in 12mns1. Failure to fulfill major role at work2. Physically hazardous3. Related legal problems4. Despite of having persistent social problems
ALCOHOL DEPENDENCE
• Any one of following in 12 mns• Increased amount of alcohol needed to achieve
desired effect & continued use of same amount• Withdrawal symptoms• Persistent desire to cut down• Important social /recreational activities given up• Increased time spent to obtain/to use /to recover
from the effects alcohol
Collection of blood for alcohol
• Spirit - not used to clean skin • Preservative –sod fluoride(100mg)+potassium
oxalate(30 mg)• Refrigerated, should not be freezed• WIDMARK FORMULA
– Wt of alcohol(gm) in body= BWT X BAC X 0.6 (men) 0.5(women)
Breath analysis
• Alcohol absorbs infra red rays• Amount of infra red rays absorbed is
proportional to alcohol contents• 60—100ml of air is receieved in a plastic
balloon • End portion of forced expiration gives correct
results• Conc in exhaled air is about 0.05% of blood
content
thank you