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Page 1: WEARABLE BIOSENSORS

WearableBioSensors

1. INTRODUCTION

Wearable sensors and systems have evolved to the point that

they can be considered ready for clinical application. The use of

wearable monitoring devices that allow continuous or intermittent

monitoring of physiological signals is critical for the advancement of

both the diagnosis as well as treatment of diseases.

Wearable systems are totally non-obtrusive devices that allow

physicians to overcome the limitations of ambulatory technology and

provide a response to the need for monitoring individuals over weeks

or months. They typically rely on wireless miniature sensors enclosed

in patches or bandages or in items that can be worn, such as ring or

shirt. The data sets recorded using these systems are then processed

to detect events predictive of possible worsening of the patient’s

clinical situations or they are explored to access the impact of clinical

interventions.

Dept.of.Electronics 1 MES College, Marampally

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2. DEVELOPMENT OF WEARABLE BIOSENSOR

2.1. RING SENSOR

It is a pulse oximetry sensor that allows one to continuously monitor heart

rate and Oxygen saturation in a totally unobtrusive way. The device is

shaped like a ring andthus it can be worn for

long periods of time without any discomfort to the subject. The

ring sensor is equipped with a low power transceiver that

accomplishes bidirectional communication with a base station, and to

upload data at any point of time.

2.1.1 BASIC PRINCIPLE OF RING SENSOR

With the amount Each time the heart muscle contracts, blood is ejected

from the ventricles and a pulse of pressure is transmitted through the

circulatory system. This pressure pulse when traveling through the

vessels, causes vessel wall displacement which is measurable at various

points .in order to detect palatial blood volume changes by photoelectric

Dept.of.Electronics 2 MES College, Marampally

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method, photo conductors are used. Normally photo resistors are used, for

amplification purpose photo transistors are used. Light is emitted by LED

and transmitted through the artery and the resistance of photo resistor is

determined by the amount of light reaching it. With each contraction of

heart, blood is forced to the extremities and the amount of blood in the

finger increases. It alters the optical density with the result that the light

transmission

through the finger reduces and the resistance of the photo resistor

increases accordingly. The photo resistor is connected as a part of voltage

divider circuit and produces a voltage that varies of blood in the finger.

This voltage that closely follows the pressure pulse.

.

2.1.2 WORKING

The LEDs and PD are placed on the flanks of the finger either

reflective or

transmittal type can be used. For avoiding motion disturbances quite

stable

transmittal method is used. Transmittal type has a powerful LED for

transmitting

light across the finger. This power consumption problem can be solved

with a light

Dept.of.Electronics 3 MES College, Marampally

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modulation technique using high-speed devices. Instead of lighting the

skiing

continuously, the LED is turned ON only for a short time, say 10-100 ns,

and the

signal is sampled within this period, high frequency, low duty rate

modulation is

used for preventing skin-burning problem

The motion of the finger can be measure with an optical

sensor. This

motion detector can be used not only for monitoring the presence of

motion but also

for cencelling the noise. By using PD-B as a noise reference, a noise

cancellation

filter can be built to eliminate the noise of PD-A that completes with the

noise

references used. An adaptive noise cancellation method is used.

Dept.of.Electronics 4 MES College, Marampally

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Fig.2.1.2.Noise Cancellation Mechanism

The noise-canceling filter combines two sensor signals, one is the

main signal

captured by PD-A and the other is the noise reference obtained by PD-B.

The main

signal mostly consists of the truce pulsate signal, but it does contain some

noise

if we know the proportion of noise contained in the main signal, we can

sensate the

contained in the main signal, we can generate the noise of the same

magnitude by

attending the noise reference signal and then subtract the noise from the

main signal

to recover the true pulsatile signal.

Dept.of.Electronics 5 MES College, Marampally

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Fig.2.1.2.Prototype of Ring Sensor

The ring has a microcomputer performing all the device controls

and low level signal processing including LED modulation, data

acquisition, filtering, and bidirectional RF communication. The acquired

waveforms sampled at 100Hz are transmitted to a cellular phone carried

Dept.of.Electronics 6 MES College, Marampally

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by the patient through an RF link of 105Kbps at a carrierfrequency of 915

MHz. The cellular phone accesses a website for data storage and clinical

diagnosis.

Power for light source, photo detector, RF transmitter and analog

and digital

processing units provided by a tiny cell battery used for wrist watches.

Lifetime is 2

to 3 weeks.

Dept.of.Electronics 7 MES College, Marampally

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Light Source

Light source for the ring sensor is the LED, approximately wavelength

of 660 nm.

Photo Detector

Photo detector is normally photodiode or phototransistor used for

detecting the

Signal from the LED.

RF Transmitter

It is used for transmitting the measured signals. Its carrier frequency

is 915MHz.

LED Modulation

Power consumption problem can be solved with a lighting modulation

technique.

Instead of lighting the skin continually the LED is turned on only for a

short time, say

Dept.of.Electronics 8 MES College, Marampally

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100-1000ns and the signal is sampled within the period. High frequency

low duty

cycle modulation implemented minimizes LED power consumption.

Data Acquisition

It is used to collect the data from sensor and data are sampled and

recorded.

Filtering

The signal from the PD-B as a noise reference a noise cancellation

filter can be

built to eliminate the noise of PD-A that correlates with the noise

reference signal

noise cancellation we use the adaptive noise filter.

2.1.4 APPLICATIONS OF THE RING SENSOR

CATRASTOPHE DETECTION

Dept.of.Electronics 9 MES College, Marampally

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Wireless supervision of people during hazardous operations

Eg: military, fire fighting.

In an overcrowded emergency department.

CHRONIC MEDICAL CONDITION

in cardiovascular disease for monitoring the hyper tension.

chronic surveillance of abnormal heart failure.

2.2 SMART SHIRT (WEARABLE MOTHERBOARD)

Dept.of.Electronics 10 MES College, Marampally

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Smart shirt developed at Georgia tech which represents the first

attempt at relying

an unobtrusive, mobile and easy to use vital signs monitoring system,

presents the

key applications of the smart shirt technology along with its impact on the

practice of

medicine, and covers key opportunities to create the next generation of

truly “adaptive and responsive” medical systems.

Research on the design and development of a smart shirt fort a

combat casualty care has led to the realization of the world’s first

wearable motherboard

or an “intelligent” garment for the 21st century. The Georgia tech wearable

motherboard (GTWM) uses optical fibers to detect bullet wounds and

special sensors and interconnects to monitor the body vital signs during

combat conditions. This GTWM (smart shirt) provides an extremely

versatile framework for the incorporation of sensing, monitoring and

information processing devices. The principal advantage of smart shirt is

that it provides for the first time a very systematic way of monitoring the

vital signs of humans in an unobtrusive ma

2.2.1. REQUIREMENTS OF SMART SHIRT

Dept.of.Electronics 11 MES College, Marampally

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Casualties are associated with combat and sometimes are

inevitable.Since

medical resources are limited in a combat scenario, there is critical need

to make

optimum use of the available resources to minimize the loss of human

life, which

has value that is priceless. In a significant departure from the past, the

loss of even

a single soldier in a war can alter the nations engagement strategy

making it all the

important to save lives.

Similarly on the civilian side, the population is aging and the

cost of the

health care delivery is expected to increase at a rate faster than it is

today. With the

decreasing number of doctors in rural areas, the doctor/patient ratio is in

certain

instances reaching unacceptable levels for ensuring a basic sense of

security when

they leave the hospital because they feel “cut off” from the continuous

watch and

care they received in the hospital. This degree of uncertainty can greatly

influence

Dept.of.Electronics 12 MES College, Marampally

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their postoperative recovery. Therefore there is a need to continuously

monitor such

patients and give them the added peace of mind so that the positive

psychological

impact will speedup the recovery process.

Mentally ill patients need to be monitored on a regular

basis to gain a

better understanding of the relationship between their vital signs and

their behavioral

patterns so that their treatments can be suitably modified. Such medical

monitoring of individuals is critical for the successful practice of

telemedicine that is becoming

economically viable in the context of advancements in computing and

telecommunication, likewise continuous monitoring of astronauts in

space, of athletes during practice sessions and in competition, of law

enforcement personnel and combat soldiers in the line of duty are all

extremely important.

2.2.2 ARCHITECTURE

Dept.of.Electronics 13 MES College, Marampally

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The GTWM was woven into a single –piece garment (an undershirt) on

a weaving

machine to fit a 38-40” chest. The plastic optical fiber (POF) is spirally

integrated

in to the structure during the fabric production process without any

discontinuities at

the armhole or the segms using a novel modification in the weaving

process.

Dept.of.Electronics 14 MES College, Marampally

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An interconnection technology was developed to transmit

information from (and to)sensors mounted at any location on the body

thus creating a flexible “bus” structure.T-connectors –similar to “button

clips” used in clothing are attached to fibers thatserve as a

data bus to carry the information from the sensors

(eg: ECG sensors) on the body.

The sensors will plug into these connectors and at the other end

similar T-connector will be used to transmit their information

for monitoring equipment or DARPS (Defense Advanced

Research Projects Agency) personnel status monitors . By making

the sensors detachable from the garments, the versatility I\of the

Georgia Tech Smart Shirt has been significantly enhanced. Since shapes

and sizes of humans will be different, sensors can be

positioned on the right locations for all users and without any

constraints being imposed by the smart shirt can be truly

“customized”. Moreover the smart shirt can be laundered without any

damage to the sensors themselves.

The interconnection technology has been used to integrate

sensors for

monitoring the following vital signs: temperature, heart rate and

respiration rate .In

Dept.of.Electronics 15 MES College, Marampally

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addition a microphone has been attached to transmit the weavers voice

data to

monitoring locations. Other sensors can be easily integrated into the

structure. The

flexible data bus integrated into the stricture transmits the information

from the suite

of the sensors to the multifunction processor known as the Smart shirt

controller.

This controller in turn processes the signals and transmit them wirelessly

to desired

locations (eg: doctor’s office, hospital, battlefield). The bus also serves to

transmit

information to the sensors (and hence the weaver) from the external

sources, thus

making the smart shirt a valuable information infrastructure.

Dept.of.Electronics 16 MES College, Marampally

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A combat soldier sensor to his body, pulls the smart shirt on, and

attaches the sensors to the smart shirt. The smart shirt functions like a

motherboard, with plastic optical fibers and other special fibers woven

throughout the actual fabric of the shirt. To pinpoint the exact location of

a bullet penetration, a “signal” is sent from one end of the plastic optical

fiber to a receiver at the other end. The emitter and the receiver are

connected to a Personal Status Monitor (psm) worn at the hip level by the

soldier. If the light from the emitter does not reach the receiver inside the

PSM, it signifies that the smart shirt has been penetrated (i.e.; the soldier

has been shot). The signal bounces back to the PSM forum the point of

penetration, helping the medical personnel pinpoint the exact location the

solider wounds.

The soldiers vital signs –heart rate, temperature, respiration

rate etc. are monitored in two ways: through the sensors integrated into

Dept.of.Electronics 17 MES College, Marampally

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the T-shirt: and through the sensors on the soldier’s body, both of which

are connected to the PSM. Information on the soldiers wound and the

condition is immediately transmitted electronically from the PSM to a

medical triage unit somewhere near the battlefield. The triage unit them

dispatches the approximate medical personnel to the scene .The Georgia

tech smart shirt can help a physician determine the extent of a soldiers

injuries based on the strength of his heart beat and respiratory rate. This

information is vital for accessing who needs assistance first during the so-

called “Golden Hour” in which there are numerous casualties.

Dept.of.Electronics 18 MES College, Marampally

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2.2.3. APPLICATIONS OF SMART SHIRT

Combat casualty care.

Medical monitoring.

Sports/ Performance monitoring.

Space experiments.

Mission critical/ hazardous application.

Fire- fighting.

Wearable mobile information infrastructure.

The vital signs information gathered by the various sensors on the

body travels

through the smart shirt controller for processing, from these, the

computed vital

signals are wirelessly transmitted using the “communication information

infrastructure” in place in that application (e.g.: the firefighters,

communication

systems, battlefield communication infrastructure, the hospital network)

to the

monitoring station. There, the back-end Data display and Management

system – with a built –in knowledge –based decision support system- in

reverse these vital signs ask in real-time and provide the right response to

the situation.

Dept.of.Electronics 19 MES College, Marampally

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Table 1 summarizes the broad range of application of the

smart shirt technology. The table also shows the application type and the

target population that can utilize the technology.

Dept.of.Electronics 20 MES College, Marampally

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Dept.of.Electronics 21 MES College, Marampally

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.

2.2.4. IMPACT OF THE SMART SHIRT

Dept.of.Electronics 22 MES College, Marampally

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The smart shirt will have significant impact on the practice of

medium since it fulfills the critical need for a technology that can

enhance the quality of life while

reducing The health care cost across the continuum of life that is from

newborns to senior Citizens, and across the continuum of medical

care that is from hospitals and everywhere in between.

The smart shirt can contribute to reduction in health care cost while

enhancing the quality of life. For instance, patients could wear the

smart shirt at home and be

monitored by a monitoring station; thereby avoiding hospital stay cost

and reducing

the overall cost of healthcare. At also same home, a home setting can

contribute to

faster recovery. For example, if the patient recovering at home from heart

surgery is

wearing the smart shirt, the ECG can be transmitted wirelessly (through

mobile

phone, internet etc) to the hospital on a regular basis. This monitoring will

help the

patient feel more “secure” and will facilitate the recuperation while

simultaneously

Dept.of.Electronics 23 MES College, Marampally

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reducing the cost time associated with recovery. Moreover, in the event of

an

emergency, the doctor can be notified instantaneously. Using the online

medical

records (available over the web) the physician can administrate the right

investment

at the right time at the right cost and indeed save a life, thereby realizing

the full

potential of the smart shirt technology.

Further more, persons who have known disorders can wear the smart

shirt and be under constant monitoring of the physical conditions by

medical personnel. Yet another potential impact of the smart shirt

technology is the eventual disappearance of geographical/physical

boundaries as barriers for individual seeking the best in healthcare

worldwide.

The smart shirt technology has the means to provide

unobstructed monitoring for individuals and can thereby play a critical

role disease management for the large numbers of individuals at risk for

high blood pressure, heart disease, diabetes, chronic bronchitis, and

depression by enabling early systematic intervention.

Dept.of.Electronics 24 MES College, Marampally

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2.2.5.ADVANTAGES OF THE SMART SHIRT

Continuous monitoring.

Right Treatment at the right

time at the right cost.

Easy to wear and takeoff.

Reducing the health care

cost.

DISADVANTAGES OF THE SMART SHIRT

Dept.of.Electronics 25 MES College, Marampally

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Initial cost is high.

Battery life is less.

3. ARCHITECTURAL REQUIREMENTS

The BITS-Life Guard computing architecture specification is centered around two computing

cores a wearable computer and a vehicular computer. The wearable computer aims to take

care of the physiological signal acquisition, their processing and communication to the

vehicular computer. Whereas the vehicular computer would utilize its resources to take care

of intensive computational tasks by collecting inputs from a heterogeneous set of sensing and

communicating devices. Figure 1(a) and 1(b) shows the hardware and software resource

requirements of the overall computing architecture. These specifications help in listing the

Dept.of.Electronics 26 MES College, Marampally

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resource requirements for different units of the BITSLifeGuard wearable computing

architecture discussed in this section.

A. Hardware Requirements

Proper selection of all hardware resources play a crucial role as inappropriate resources may

lead to an increase in the weight, cost, size and development time in such systems.

Optimization of resource-utilization would eliminate all such burdens and result in a

simplified and user friendly solution. In devising architecture for a particular wearable

computing device following four important hardware components play an important role:

a) Processing Core : Selection of processor is influenced by the scope of the application.

Initial wearable prototypes used multimedia (audio and image) processing using a general-

purpose CPU alone. With the availability of heterogeneous multicore system-on-chip (SoC)

and partitioning the system specific task and DSP task, it has become possible to minimize

cost and power consumption, achieve higher performance rate while the complexity

increased for the embedded software developer to manage additional processor with respect

to its programming and debugging [24]. The choice of processor is primarily governed by its

energy conservation characteristics and the on-chip peripheral support that may include

wireless radio transceivers, serial communication channels etc. Majority of the power

consumed in a typical handheld or PDA device has been found by the units like its processing

core, during memory access, active speakers, back-light and front-light [25]. Cores that use

dynamic voltage scaling save power using software in its idle, sleep or active mode are

preferred nowadays in portable system design [26]. These typical systems may consume

power from 324 mW to 900 mW on an average battery power of 3.75 V to 9V. Voluminous

data collected over a period needs to be transferred to a back-end processing system without

Dept.of.Electronics 27 MES College, Marampally

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burdening the processor (saves processor’s power consumption), thereby peripherals role like

that of a DMA becomes crucial at this juncture.

b) Communication Medium: Since the processing of acquired signals done on the fly,

situations like (a) alarming the driver itself (b) inform persons who may be forming a

personal area network due to being inside or around the vehicle, and (c) in case the driver

does not respond to the alarm, sending an SOS signal to the vehicular computer to take

further action. This requires that the short-range radio selected for this purpose must have

good coverage area, no line-of-sight problem as well as a good amount of security

implemented in the protocol stack of the channel itself thereby reliving the processing core

from intensive computation as needed in the case of encryption and decryption algorithms.

The data transfer rate of the wireless channel influences the design in a way that the

physiological data which require further processing at the back-end (vehicular computer)

must be relayed at regular intervals due to less on-chip memory availability. As

communication radios consume more power during transmission and reception their exact

power requirements must be met in accordance with the required design.

c) Physiological Sensors : Unobtrusiveness is the key; i.e. in any manner user’s comfort

should not be compromised. Care must be taken in selection of electrodes which are

disposable, require frequent gelling, and may produce some kind of skin ailments or health

hazards. Appropriate sensors specific to a particular application must be selected by

considering its electrical characteristics such as power consumption, sampling frequency and

mechanical characteristics such as size, robustness as well as some environmental

issues like extreme weather conditions and its ability to operate for long hours. The reliability

and operability of sensors in wearable conditions not only influence the design but also

facilitates the acceptability of these sensors in such a situation. Overall system design may

Dept.of.Electronics 28 MES College, Marampally

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also be governed by issues like choice of appropriate sensor type, sensor dimensions, location

of sensors, power source, wireless scommunication range, mounting mechanisms,

configuration and body safety due to wearable sensors.

d) Supporting Peripherals : Besides the above key requirements the supporting device

selection becomes

crucial if one had to build a body network of wired sensors. This may also include the analog

signal conditioning circuits to convert the sensor data into a digitized form. Wired connection

of sensor nodes require that the communication to the processing unit be properly timed such

that critical health related events should not be lost. Proper selections of baud rate, serial bus

technology to be used, wireless channel communication rate etc. are some of the critical

points. This selection is also influenced by the on-chip peripheral support of the processing

core.

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at the back-end (vehicular computer) must be relayed at regular intervals due to less on-chip

memory availability. As communication radios consume more power during transmission

and reception their exact power requirements must be met in accordance with the required

design.

B. Software Requirements

The real challenge lies in such system to have an operating system to meet the real-time

requirements of the larger system. Managing all resources and their timing is critical as large

latency in responding to a specific task especially in an emergency would lead to loss of a

life. A better solution could be to use a hard real-time operating system with small foot-print,

less memory requirements, low latency, and with kernel reconfigurability support. A choice

Dept.of.Electronics 30 MES College, Marampally

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has to be made based upon the development support with a specific OS like what processor

architecture does it support, features of the development tools (Integrated Development

Environment), what kind of API support available and other above mentioned requirements

such that development would be less cumbersome and robust.

C. Functional Requirements

Since the target application aims to assist drivers by knowing their health status, physical and

mental fitness, fatigue level and other related parameters, it is required that the devices

including the sensors may not let the driver in an awkward situation as well as distractions of

any kind due to their placement, weight, size, overheating when the device is active must be

avoided. The wiring connections in case of body network of wired sensors must not obstruct

the driver’s normal driving. These issues can be tackled using proper design considerations.

The functional requirements are influenced by the driver’s age, his behavioral habits during

driving etc.

4. FUTURE TRENDS

By providing the “platform” for a suite of sensors that can be utilized

to monitor an individual unobtrusively. Smart Shirt technology

Dept.of.Electronics 31 MES College, Marampally

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opens up existing opportunities to develop “adaptive and

responsive” systems that can “think” and “act” based on the users

condition, stimuli and environment. Thus, the rich vital signs delta steam

from the smart shirt can be used to design and experiment “real-time”

feedback mechanism (as part of the smart shirt system) to embrace the

quality of care for this individual by providing appropriate and timely

medical inspections.

Certain individuals are susceptible to anaphylaxis

reaction (an allergic reaction) when stung by a bee

or spider and need a shot of epinephrine (adrenaline)

immediately to prevent above illness or even fatalities. By applying

advancement in MEMS (Micro-Electromechanical Systems) technology, a

feedback system including a dry delivery system-can be integrated into

the smart shirt. Of course mechanism to guard against inadvertent

administration of dry can be built as a part of the control system.

Likewise, the Smart shirt’s delta acquisition

capabilities can be used to detect the condition when an individual is

lapsing into a diabetic shock and this integrated feedback mechanism can

provide the appropriate response to prevent a fatality. Thus, the smart

shirt represents yet another significant milestone in the endeavor to save

and enhance the quality of human life through the use of advanced

technologies.

Dept.of.Electronics 32 MES College, Marampally

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Dept.of.Electronics 33 MES College, Marampally

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5 . CONCLUSION

The ring sensor and smart shirt are an effective and comfortable,

and mobile

information infrastructure that can be made to the individual’s

requirements to take

advantage of the advancements in telemedicine and information

processing. Just as

special-purpose chips and processors can be plugged into a computer

motherboard to obtain the required information processing capability, the

smart shirt is an

information infrastructure into which the wearer can “plug in” the desired

sensors

and devices, thereby creating a system for monitoring vital signs in an

efficient and

cost effective manner with the “universal“ interface of clothing.

Dept.of.Electronics 34 MES College, Marampally

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Advanced technologies such as the smart shirt have at partial to

dramatically alter its landscape of healthcare delivery and at practice of

medicine as we know them today. By enhancing the quality of life,

minimizing “medical” errors, and reducing healthcare costs, the patient-

control wearable information infrastructure can play a vital role in

realizing the future healthcare system. Just as the spreadsheet pioneered

the field of information processing that brought “computing to the

masses”. It is anticipated that the smart shirt will bring personalized and

affordable healthcare monitoring to the population at large, thus leading

to the realization of “Affordable Healthcare, Any place, Anytime, Anyone”.

6 . REFERENCES

1. H.Harry Asada, “Mobile monitoring with wearable ppg sensors”,IEEE

engineering in medicine and biology magazine,vol 22, pp- 28-39 may/june

2008.

2. Park and Jayaraman,”Enhancing the quality of life through wearable

Dept.of.Electronics 35 MES College, Marampally

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technology”, IEEE engineering in medicine and biology magazine,vol 22,

pp- 41-48 may/june 2008.

3. Handbook of biomedical instrumentation ,Khandpur ,pp-138,233,238

4. R.Neuman,”Biomedical sensors”,handbook of biomedical

instrumentation,pp-725-755

5. http://www.smartshirt.gatech.edu

6. http://www.wearables.gatech.edu

Dept.of.Electronics 36 MES College, Marampally


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