Qheart = 0L/min

t0: Q = 0Qresistance vessles = 0L/min

Parteries = 7mmHgPveins = 7mmHg

t0: Q = 0Mean Circulatory Pressure or Static Pressure = 7mmHgCompliance and Volume only factorsFlow = 0

1)Stepwise increase in COSee how CVP changes

SVR = 20mmHg/L/min

Cardiace Output increase = decrease in CVP

t1: Q = 1Initial increase in CO-Blood redistributes from Venous circulaiton-Blood accumulates in Arterial circulationthis is due to an IMBALANCE between output from the Heart and Resistance vessles T1: Q = 1

Qrv < (Qco =1)

Pressure hereincreasesPressure

Here decreases

P here providesDriving Force requiredto Match ow throughResistance vessels with

CO

P

P depends on SVR

Qvein = Qresistance vessels

Veins Resistance Vs

= Volume = 1

19191 Pressure

Compliance xCompliance x 1919

Pressure1919

constant, same for veins and resistance vessles

dV = C x dP

Compliance Arteries = 1Compliance Veins = 19

dPveins = 1 dPresist vs = 19

Card

iac

Out

put L

/min

CVP mmHg

1

2

3

4

5

6

7

-1 0 1 2 3 4 5 6 7 8 9

8

9

Mean Circulatory

Pressure = 7mm

Hg

Cardiac output0 1 2 3 4 5 6 7

140

130

120

110

100

90

80

70

60

50

40

30

20

10

0

Arterial Pressure m

mH

g

7

6

5

4

3

2

1

0

-1

Veno

us P

ress

ure

mm

Hg

Resistance: 20mmHg/L/minCompliance: Cveins 19x Cartery

Blood Volume: Mean Circulatory Pressure = 7mmHg

CO: independent variable

Vascular Function Curve

Vascular Function Curve

Factors that aect Vascular Function Curve1) Volume: shifts parallel2) Resistance: Rotates3) Venous Compliance: -Changes mean circulatory pressure (+) venous Com = (-) MCP -Venous Compliance also changes slope

Cardiac output = Venous Return

Cardi

ac Fu

nctio

n = Cu

rve St

arling

Curve

Equilibrium Point = where CV system is operatingCO = 5 CVP = 2, only point that really exists

Increased Blood Volume

(-) inotropic state(+) Afterload(-HR)

(+) HR(-) Afterload(+) Inotropic state

Decresed Blood Volume

Increase SVR

Decrease SVR