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Page 1: Supplementary Figure 2

Supplementary Figure 2

HEK293 MRC-5 SKOV-3 MDAH-2774

anti-IGFBP-5

anti--actin

Igfbp5 mRNA

Gapdh mRNA

0

500

1000

1500

2000

tum

or v

olum

e (m

m2)

mock IGFBP-5

*

IGFBP-5mock

num

ber

of b

lood

ves

sels

per

tum

or s

ectio

n

0

5

10

15

20

anti-CD31 (PECAM-1)

IGFBP-5mock

mock IGFBP-5

*

A

B

Supplementary Figure 1

Page 2: Supplementary Figure 2

Supplementary Figure 3

anti-IGFBP-5

anti--actin

untreated 10 ng/ml 50 ng/ml 100 ng/ml

VEGF

anti-IGFBP-5

anti--actin

Igfbp5 mRNA

Gapdh mRNA

untreated IGF-1 (100 ng/ml)

Supplementary Figure 4


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