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Page 1: Student Research Interest HER2 Receptor Signaling in Breast Cancer Cells Marc Y. Fink Biomedical Sciences LIU-Post

Student Research InterestHER2 Receptor Signaling in Breast Cancer Cells

Marc Y. FinkBiomedical Sciences

LIU-Post

Page 2: Student Research Interest HER2 Receptor Signaling in Breast Cancer Cells Marc Y. Fink Biomedical Sciences LIU-Post

HER2 and Breast Cancer

• Amplification or chromosomal region 17q12• RTK of the EGFR-family• HER2 is overexpressed and induces a state in

which proliferation and survival are increased• Several drugs are approved for molecularly

tailored treatment (trastuzumab and lapatinib)• They often induce resistance after 1-2 years of

treatment

Page 3: Student Research Interest HER2 Receptor Signaling in Breast Cancer Cells Marc Y. Fink Biomedical Sciences LIU-Post

HER2 SignalingHER2

PP

PI3K

AKT

Grb2

Shc

SOS

Ras

TSC2TSC1Raf

MEK 1/2

ERK 1/2

RSK

mTORC 1

p70S6k

S6

Rheb

*

* *

PP

IGF1R

PP

FGFR

What are the intracellular targetsthat may be useful for targeting HER2-breast cancers?

How does the network reorganize after HER2 inhibition?

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