Hodgkin-Huxley model simulator
Katrin Valdson Kristiina Pokk
Marit Asula
Tartu 2015
Introduction
I� = g�(V − E� )+ g�n⁴(V − E�)+ g�ₐm³h(V − E�ₐ)
Simulator
Simulator
Topics of the simulator exercises
Part I: Equilibrium PotentialPart II: Membrane PotentialPart III: The Action PotentialPart IV: The Fast Sodium ChannelPart V: The Delayed RectifierPart VI: Voltage-Gated Channel Parameters
TTX
● neurotoxin● found in pufferfish, octupuses,
marine worms, amphibians● deadly in very small amounts● blocks Na ion channels● prevents action potential from
happening
TEA
● Tetraethylammonium
● found in simple salts
● used in pharmacological research
● blocks K ion channels● prolonged action potential
Pronase
● group of proteolytic enzymes● extracellular fluid of a species
bacteria in soil● blocks only the Na inactivation gate● results in prolonged action potential