Shockby
Momen Ali Khan
Definition
Shock is a systemic state of tissue hypoperfusion which is inadequate for normal cellular respiration
Symptoms signs Cold clammy skin Tachycardia Palpitation Hypotension Restlessness Decrease urinary output Confusion Tachypnoea Coma
CellularMicrovascularCardiovascularRespiratoryRenalEndocrine
CellularIn shock at cellular level decrease supply of oxygen ( hypoxia) and nutrient supply ( such as glucose)So,
HypoxiaSwitch to anaerobic metabolismIncrease lactic acid production
Systemic metabolic acidosis
Glucose exhausted
Ceasation of anaerobic respiration (So no production of ATP)
Failure of sodium-potassium pumpRelease of intracellular lysosomal autodigestive enzymes
Cell lysisRelease of intracellular potassium and cellular content into
blood
So there release of
AcidPotassiumCellular and humoral content ( complement ,
neutrophil)
Into blood
cre
Microvascular
Hypoxia and acidosis activate complement and prime neutrophil
Endothelium damaged and become leaky
Fluid leak out and causes tissue edema, excerbating hypoxia
Cardiovascular
Decrease preload and afterload
Increase sympathetic activity
Tachycardia and systemic vasoconstriction
Respiratory Metabolic acidosis and increases sympathetic activity
Tachypnea
Renal Decrease perfusion pressuere
Reduced filtration
Decrease urine output
Endocrine
Activation of adrenaline and RAAS axis
Increase release ADH
Vasoconstriction and resorption of water in renal collecting system
Cortisol also causes sodium and water reabsorption
Classification of shock
Hypovolemic shock Cardiogenic shock Obstructive shock Distributive shock Endocrine shock
Due to reduced circulating volume
Causes1. Haemorrhagic2. Non –haemorrhagic
Poor fluid intake – dehydrationExcessive fluid loss-vomiting , diarrhea, urinary loss (diabetes)Third space loss in GIT, interstitial space- e.g. intestinal obstruction, pancratitis
Primary failure of heart to pump blood to tissues
CausesMyocardial infarction Cardiac dysrhythmiaValvular heart diseaseCardiomyopathyMyocardial depression
Reduced in preload due to mechanical obstruction in cardiac filling
CausesCardiac tamponadeTension pneumothoraxMassive pulmonary embolus
Distributive shockEvents in distributive shock
Vascular dilatationLow systemic vascular resistanceInadequate afterloadInadequate organ perfusio
Causes Anaphylaxis ( due to histamine release)Septic shockSpinal cord injury (failure of sympathetic outflow)
Endocrine shockMay present as combination of hypovolaemic,
cardiogenic, distributive shock.
CausesHypothyroidism – cardiac output fall due to low inotropy and
bradycardia.Hyperthyroidism- high output cardiac failureAdrenal insufficiency
O
Compensated shockDecompensationMild shock Modetrate shokSevere shock
Pitfalls Capillary refill- it is not a specific marker. In distributive shock peripheries are warm and capillary refill are brisk.
Tachycardia- may not always accompany shock. Pateint on beta blocker or implanted pacemaker unable to mount tachycardia. Yo ng patient in penetrating trauma with hemorrhage but little tissue damage show paradoxical bradycardia.
Blood pressure – last sign of shock. Young patient and adult are able to maintain blood pressure untill final stage.
ImmediateABCD Management Ensure patent airway adequqte oxygenation
Determine the type, nature of shock, if not possible safer to assume as hypovolemic shock
N-
Fluid therapyAlways start with crystalloid
For exampleHartmann’s solutionNormal saline
Pulse Blood pressureUrine output- normal 1ml/kg/hourOxygen saturation- by pulse oximetry
Some notes
If patient with active bleeding (major trauma, GIT hemorrhage) must control bleeding and fluid resuscitation run simultaneously. Transfused blood if required.
Patient with bowel obstruction – hypovolaemic shock resuscitate adequately before undergoing surgery