Reduced viral reservoirs in HIV-infected youth following early cART: A long-term follow-up report by Luzuriaga et al.Zeena Nackerdien

Effects of Sustained Virologic Control in Early-Treated HIV-1- Infected Children

cART, combination anti-retroviral therapy; rep., replication1 Luzuriaga K, Tabak B, Garber M, Chen YH, et al. Reduced HIV Reservoirs After Early Treatment HIV-1 Proviral Reservoirs Decay Continously Under Sustained Virologic Control in Early-Treated HIV-1- Infected Children. The Journal of Infectious Diseases. 2014 (e-pub).

Long-term follow-up (up to 18 years)

4 infected youth who received ART during established infection

(6-14.7 y) also included

cART started between 2 & 11 weeks of age

Perinatally infected youth (aged 14-18)

CONCLUSIONSEarly, effective

cART from infancy significantly limits

circulating levels of proviral and rep.-

competent HIV-1 & promotes

continuous decay of viral

reservoirs