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Project Number: 257401
A highly integrated and sensitive POrous SIlicon based lab on a chip for multiple quantitaTIVE monitoring of food allergies at point of care.
Specific Targeted Research Project
Information Society Technologies
Deliverable D11.15: End of project roadmap for the use and dissemination of foreground – Section A (Public)
Due date of deliverable: February 28 2014
Actual submission date: May 19th 2014
Start date of project: 2010-09-01 Duration: 3 1/2 Years
Organisation name of lead contractor for this deliverable: UVEG
Revision [1.0]
Project co-funded by the European Commission within the Seventh Framework Programme
Dissemination Level
PU Public X
PP Restricted to other programme participants (including the Commission Services)
RE Restricted to a group specified by the consortium (including the Commission Services)
CO Confidential, only for members of the consortium (including the Commission Services)
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1 About this deliverable
1.1 Introduction
This report describes the end of project roadmap for the use and spread of the knowledge generated, or foreground, during the project lifetime.
For the spread of knowledge (dissemination) the strategies employed by the consortium members and the achievements in disseminating the knowledge generated during the project lifetime are reported. This includes participation in workshops, conferences, EC related events, standardisation bodies, etc. Positive members participated and shared information and resources with on-going R&D activities or entities, such as NoEs, IPs or any other horizontal network.
For the use of the knowledge, exploitable foreground technologies were identified, listed and individual exploitation plans developed for them given the interest and vision at the time. Where necessary from the IP observatory patent reviews were performed in order to identify a freedom to operate and unique selling points also identified as part of business plans.
The report therefore consists of:
Section A: describing the dissemination measures, including any scientific publications relating to foreground. Its content can be made available in the public domain thus demonstrating the
added-value and positive impact of the project on the European Community.
Section B: This section specifies the exploitable foreground and provides the plans for exploitation. This section must be kept confidential and must be treated as such by the Commission.
1.2 Scope of the deliverable
The deliverable outlines an end of project roadmap for the use and spread of the knowledge generated during the project lifetime. It consists of two parts A and B, the first public and the second confidential and therefore is delivered as two separate documents.
1.3 Structure of this deliverable
The report is laid out according to the tasks defined in WP11 as follows:
T11.3: Elaboration of roadmap for use and dissemination of foreground. (UVEG)
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2 Section A – Dissemination (for public knowledge)
This section includes a list of dissemination activities (publications, conferences, workshops, web, press releases, flyers, etc) realised throughout the project. In addition, a list of scientific (peer reviewed) publications is provided.
2.1 Setup of Positive web-site
At the start of the project an interactive webpage, www.fp7positive.eu, was designed and published to allow world-wide knowledge of the activities and results of the project as well as co-ordination between partners (file exchange, etc) by M3 (Deliverable D11.1). Later it underwent a major revision improving its style and content. Throughout the project it has been updated with information of interest to the scientific community, medical instrumentation industry as well as the general public.
2.2 Creation of promotional material
During the project we aimed to publicize the project and its results through the creation of promotional material for broader dissemination at key events and through a newsletter to a regularly updated database of contacts (= the Positive INTEREST GROUP, see section 2.4.2).
A first set of promotional material was created in M3 (D11.2), and then updated in M12 (D11.7), M27 (D11.12) before a final update was made in M45 (D11.14 and D11.17). The promotional material consists of a project leaflet/flyer, a poster, a short presentation and a newsletter. UVEG leads this work, with active assistance of all partners.
2.2.1 Project leaflet
A first leaflet was created and printed by M3 containing 4 A5 sides with general information about the project, its objectives and its partners. Changes in the second leaflet (M14) reflected the new project coordinator and some minor style changes, 500 copies were professionally printed. They were distributed at various dissemination events: Student Open Days, MNBS concertation meetings, ICT Proposers days and EC Workshop on Cross-KETs for Healthcare. The third flyer (M27) includes highlights of technical achievements to date in the project whilst the final flyer (M45) overviews the best technical achievements from the project. The leaflets can also be downloaded from the Positive website.
2.2.2 Poster
A first poster, containing general information about the project, its objectives and its partners was created, printed and used by the partners from M3. Posters generated since have contained more and more technical results as they have become available within the project. These posters were presented annually at Medica and the MNBS concertation day as well as other events such as CLEO, EuroNanoForum, FP7-IP-HELIOS and UK Silicon Photonics (UKSP) organised photonics summer school, a workshop on Nanophotonics for sensing and nonlinear optics organized by the University of Adelaide, PECS IX, MicroTAS2011, Nanotech Italy 2011, MEMs2012, Student Open Days, Europtrode 2012, Euromediag Convention…..
2.2.3 A short presentation
Updated standard presentation material was kept available for all partners on the basis for incorporation into more detailed presentations or for use ad hoc at opportunities where the partners can present their on-going work. The standard presentation was incorporated into oral presentations at various EC organized events (Biophotonics cluster meeting, Photonics open day, MNBS concertation days) as well as various scientific workshops and conferences as regular
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papers (Photonics West 2012, PSST 2012, IEEE Sensors 2012, SPIE Microtechnologies 2013,…) or invited papers (pHealth, 26th International Symposium on MicroScale Bioseparations, Advances in microarray technology, Therapeutics for personalized medicine…).
2.2.4 A newsletter
An annual newsletter was created and distributed to the Positive INTEREST GROUP (including the Europrevall, Ga2LEN and SMARTHEALTH consortia) in months M4, M14, M27 and finally M45. As well the general introduction given in the first, the next contained achievements of Year 1, UNITN and their porous silicon membrane development. The 3rd newsletter was sent to the INTEREST GROUP highlighting technical achievements from Y2, CNR and their surface functionalization developments. The final newsletter followed in M45 (see also section 2.4.2.) focused on key project progress and novel foreground as well as included a feature on CSEM and their microfluidics and optics work in Positive.
2.3 Dissemination among other FP7 RTD projects
The consortium participants have been disseminating to and cooperating with other FP7 RTD projects where possible. Contacts have been made and weblinks (http://www.fp7positive.eu/projects.html) are provided to the projects Europrevall, Ga2Len and Nanospad.
The consortium participants cooperated with other FP7 RTD projects in the area of microsystems and photonics and exchanged non-confidential information with these projects particularly through the participation in periodic concertation meetings and as partners themselves in those projects.
Table: Dissemination events to other FP7 RTD projects
Date Event Responsible Positive partner
Newsletters 1-4 The Europrevall, Ga2LEN and Nanospad consortia UVEG
M3 Biophotonics cluster meeting presentation KTH
M3 Photonics Open Day KTH
M5 Interchange with coordinator of FP7 Mash project UVEG
M8 EC MNBS Concertation meeting UVEG
M11 Silicon Photonics summer school (Poster) organized by FP7 HELIOS and UKSP.
UVEG
M18 CFBI organized meeting for Microfluidics Group UVEG
M20 Interchange with FP7 FoodMicrosystems project UVEG
M21 MNBS Concertation meeting UVEG
M21 EC MNBS Concertation meeting UVEG
M25 ICT Proposers Day UVEG
M25 COWIN Market Place, Paris. CSEM
M27 EC MNBS Concertation meeting UVEG
M37 EC MNBS Concertation meeting UVEG
M39 EC-WS on Cross Key enabling technologies for Healthcare with presentation topics
UVEG
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2.4 General publicity of the project
Further publicity has taken place through the dissemination of Positive research results to the non-scientific/technical media at large (eg. newspapers, magazines, TV, periodicals) and raising of public awareness for the project and interest in photonic technologies at "student days", "open days", "girls days".
2.4.1 Press releases
Whenever a good opportunity presented itself, Positive disseminated its results via the larger press. These opportunities were either pursued actively, e.g. when critical results were obtained, or occurred on an ad-hoc basis when the partners were contacted by the press in conjunction with the general research activities.
Table: planned press releases.
Date Press release content Responsible Positive partner
M4 Project start:
http://www.kth.se/en/aktuellt/supersnabba-allergitest-snart-har-1.74636
http://www.kth.se/en/ees/omskolan/organisation/avdelningar/mst/news/quick-food-allergy-test-just-a-drop-of-blood-1.73580
KTH, with help from all
M4 Project start in the Farfield Periodical NewsLetter, Illuminations 14: http://www.farfield-group.com/pdfs/Newsletter_Issue_14.pdf
Farfield
M5 Farfield Group Press release:
Farfield Join Forces to Detect Hypersensitivity of Allergens
http://www.farfield-group.com/readstory.asp?sid=113
Farfield
M7 Press release done through Euromediag diffusion list (http://www.eurobiomed.org/en/euromediag/) in which Phylogene is involved. Euromediag is a group of diagnostics actors inside Eurobiomed competitivity pole. Euromediag also initiated a EU meta-cluster which includes Euromediag (Eurobiomed-France), Wal-DX (Biowin-Belgium), Biocat (Barcelona, Spain), Kakow life Sciences cluster (Poland), Nexxus (Scotland- UK), OBN (Oxford, UK), Uppsala Bio (Uppsala - Sweden) and ZMDB (Berlin-Brandebourg - Germany).
Phylogene
M7 Press-release through Almanacco della Scienza
(http://www.almanacco.rm.cnr.it/reader/ ?MIval=cw_usr_view_articolo.html&id_articolo= 1753&id_rub=13&giornale=1760)
CNR
M29 A press-release in M29 highlights the major technical achievements since the project began.
UVEG + CNR
M45 A press release announcing innovation developed within the whole project will be released at the end of M45.
UVEG + CSEM
The first press-release was quickly picked up by sources in Sweden and around the world, including:
Swedish National Radio interviewed Prof. van der Wijngaart http://sverigesradio.se/sida/gruppsida.aspx?programid=406&grupp=12718&artikel=4290223
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Swedish National Television interviewed Prof. van der Wijngaart http://www.tv4play.se/nyheter_och_debatt/tv4nyheterna?title=blodchip_kan_avsloja_allergier&videoid=1215225
An enquiry came from the Aftonbladet Swedish Tablet
NYTEKNIK (the number one technology newspaper in Sweden) http://www.nyteknik.se/nyheter/innovation/forskning_utveckling/article3063070.ece
An enquiry came from two Swedish highschool (natural da Vinci in the Kattegat High School in Halmstad) girls for a school assignment.
The Illinois-Sweden Program for Educational and Research Exchange (INSPIRE) http://illinois.edu/lb/imageList/3833
http://www.righthealth.com/topic/scratch_tests_allergy/BlogPosts
Ann Göransson Nyberg, the project manager from EU project MASH ”Mass casualties and Health care following the release of toxic chemicals or radioactive material”.
Per Matsson, Chief Technology Officer of Phadia AB and Associate Professor, Uppsala University
Emelie Nyman, a freelance journalist, working for the Campus magazine that goes out to students across the country in engineering, economics and law. Contacted for article.
A local newspaper in Trento published an article on consultation.
Article in Italian national newspaper http://www.sanitaliaweb.it/index.php?option=com_content&view=article&id=542:progetto-positive-il-test-per-le-allergie-alimentari&catid=15:news-italia&Itemid=107
Article in Italian Family Church Magazine
Italian Television
A contact from communication consultant for Parliament Magazine’s Research Review.
A recent contact from a representative of Europes Leading Scientific Dissemination Portal – Research Media Ltd.
Following the second press-release of M29 follow-ups included:
7 regional and national radio, television and newspaper contacts
A contact Prof Alcocer from the U. Nottingham who is working with a similar assay
Brazilian Society of Clinical Pathology
Two members of the general public
RUVID
Chemistry & Industry - UK Magazine
Prachi Patel, Science and technology writer
We expect to receive similar if not greater interest from our 3rd and final press-release which is scheduled for the end of M45.
2.4.2 The user forum
Positive identified an INTEREST GROUP to which promotional material was distributed at M4, M14, M27 and M45 in the form of annual newsletters. The INTEREST GROUP is basically an email list that contains key players and experts from Industry (most of them from European companies), governmental agencies and academia. The INTEREST GROUP currently consists of >200 entities.
2.4.3 "Student days" and "Open days"
All partners were to identify a suitable event close to the M24 date in which they were to disseminate the Positive project and its results to the broader public. Due to the lack of opportunities however it was decided to hold events as and when they became available at each partner.
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Table: Public events targeted for Positive dissemination
Date Event Responsible Positive partner
M20 Positive open day at KTH in connection with the bi-annual Course Fair for the students
KTH
M21 Expociencia 2012 UVEG
M39 Medica 2013 Phylogene
M19 Positive Students day CNR
M7 Open day at Univ. of Trento. NL group disseminated POSITIVE related activities to undergraduate students that will visit the Nanoscience research group laboratories
UNITN
M18 Public dissemination event “Realizzazione di un sensore point-of-care in silicio poroso per analisi quantitative delle allergie alimentari”, 10 February 2012, City Hall of Levico Terme (Italy).
UNITN
M15 Nationaler Zukunftstag 2011, open day for students to visit CSEM’s facilities in Alpnach
CSEM
M18 Information day at CSEM for Executive MBA course from HSLU CSEM
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2.4.4 Other dissemination events
Table: Other dissemination events
Date Event Responsible Positive partner
M1 PECs IX KTH
M9 CLEO (Poster) UNITN
M9 Therapeutics for personalized medicine (planned, invited talk) UVEG
M9-10 EuroNanoForum UVEG
M10-11 pHEALTH 2011 (invited talk) UVEG
M11 UK FP7 ICT meeting Farfield
M11 Silicon Photonics summer school (Poster) UVEG
M12 Nanophotonics for sensing & nonlinear optics workshop UNITN
M13 Swedish Medical Technology Days KTH
M14 Medica 2011 Phylogene
M14 NanoTech Italy 2011 UVEG
M18 CFBI organised meeting for Microfluidics Group UVEG via Ikerlan
M19 European Lab-on-a-Chip Congress KTH
M19 Swedish MEMS conference (http://www.msw2012.org/), KTH
M21 MNBS UVEG/UNITN
M21 Euromediag Convention Phylogene
M25 ICT Proposers Day UVEG
M25 Information on optical packaging technology for MCCS (Micro Center Central Switzerland, organization with 17 shareholders)
CSEM
M25 Cowin Market Place, Paris 2012 CSEM
M27 Medica 2012 Phylogene
M34 DPI User Meeting Farfield
M30 Italian national conference UNITN
M34 WaferBond ‘13 KTH
M37 Italian national conference UNITN
M39 ASME UVEG/UNITN
M39 MNBS UVEG
M25 28th International Symposium on MicroScale Bioseparations and Analyses.
CNR
M31 AMT2013 CNR
M33 Nanotech 2013 CNR
M42 Swedish national conference MSW 2014 KTH
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2.5 Communications to scientific journals and conferences/workshops
The project research results obtained were either protected by patenting and/or published at international conferences, EU-workshops and refereed journals, such that dissemination activities to the scientific community and the European Diagnostics industry are as follows:
Publications in leading scientific and technical journals in the field
Publications in leading international conferences.
International exhibitions (usually co-located in major conferences).
Concertation meetings and topical clusters.
2.5.1 Conference communications
1st reporting period: Poster presented at PECS IX "Simulation of porous silicon photonic crystals for biosensing". -
UVEG, KTH
Invited talk at Advances in microarray technology, “Silicon Chips with Dual Label-Free and Fluorescence Detection for High Sensitivity Diagnostic Protein Microarrays“ – CNR
Invited talk at 26th International Symposium on MicroScale Bioseparations, “Silicon biochips for dual label-free and fluorescence detection: application to protein microarrays development.” – CNR
Invited talk at Therapeutics for personalized medicine “Microfluidic and Sensor Technologies for Lab on a Chip Applications” – UVEG
Invited talk at pHealth “The need for nutrition monitoring and Lab on a Chip based technologies as solutions” – UVEG
2nd reporting period: Poster presented at MicroTAS2011, "Low temperature "click" wafer bonding of
offstoichiometry thiol-ene(oste) polymers to silicon" - KTH Poster presented at MicroTAS2011, "Biostickers: patterned microfluidic stickers for rapid
integration with microarrays" - KTH and CNR Oral presentation at SPIE Photonics West, "Highly-Sensitive Anisotropic Porous Silicon
based Optical Sensors" - UVEG and UNITN Oral presentation at Fotonica2012 “n-Type Porous Silicon Optical Micro-Cavity”, UNITN Poster presented at Europtrode, “Mesoporous silicon for phase sensitive biosensing” - UVEG Oral presentation at PSST, “Optimization and synthesis of thin transparent free standing
ntype porous silicon membranes” - UNITN. Poster presented at MEMs 2012, "Dry transfer bonding of porous silicon membranes to
OSTE(+) polymer microfluidic devices" - UNITN and KTH Oral presentation at SSI-2012, “Photonic sensing of food allergens: integration and
miniaturization” – CSEM on behalf of the consortium Oral presentation at IEEE Sensors 2012 “A polarimetric sensor based on nanoporous
membranes“, UNITN and UVEG
3rd reporting period Oral presentation at IEEE Transducers, “Polarimetric based biosensor with targeted delivery
of analytes for real-time monitoring of molecular interactions” - UNITN, UEG, Farfield, KTH, CSEM.
Oral presentation given at Italian National Conference, “High sensitivity, free standing macroporous silicon cavities fabricated in n-type substrates” – UNITN
Oral presentation given at Italian National Conference, “A case study of the optimization of a nanoporous material for sensing applications” – UNITN
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Oral Presentation at SPIE Microtechnologies – “Real-time polarimetric biosensing using macroporous alumina membranes” – UVEG, CNR, Farfield
Poster presentation at WaferBond 2013, “Dry adhesive bonding of porous alumina membranes to microstructured silicon wafers using the OSTE(+) dual-cure polymer” – KTH
Poster presentation at Micro and Nanosystem Workshop 2014, “Dry adhesive bonding of porous membranes to microstructured silicon wafers using the OSTE(+) dual-cure polymer” – KTH
Oral presentation at ASME (Invited Talk), “Anisotropic nanoporous materials” – UVEG, UNITN
Oral presentation at 28th International Symposium on MicroScale Bioseparations and Analyses " Polymer coatings in micro-system platforms for biosensing" - CNR
Oral presentation at AMT 2013 Advances in Microarray Technology, " A Dual Label/Label Free, Highly Sensitive Protein Microarray Platform for Molecular Diagnostics" - CNR
Poster and conference proceedings at 2013 NSTI nanotechnology Conference & Expo - Nanotech 2013 " Reduction of the hydrophobicity of thiol-ene microfluidic devices using an adsorbed polymeric coating" - CNR
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2.5.2 Peer reviewed scientific publications
LIST OF SCIENTIFIC (PEER REVIEWED) PUBLICATIONS, STARTING WITH THE MOST IMPORTANT ONES
No. Title Main
author
Title of the periodical or the
series
Number, date or
frequency Publisher
Place of publication
Year of publication
Relevant
pages
1
Simulation of Surface-Modified Porous Silicon
Photonic Crystals for biosensing applications
Issac Suarez
(UVEG)
Photonics and Nanostructures - Fundamentals
and Applications
V10 Elsevier Amsterdam 2011 304-311,
Doi:10.1016/j.photonics.2011.04.014
2
Birefringent Porous Silicon Membranes for Optical
Sensing
Jesús Álvarez
(UVEG)
Optics Express V9, I27 OSA Washington 2011 26106- 26116,
10.1364/OE.19.026106
3
Advances in nanophotonic sensing technologies
during three international Label Free Lab-on-Chip
projects
Daniel Hill
(UVEG)
Journal of BioNanoScience
V1, I4 ASP Valencia, California
2011 162-172,
10.1007/s12668-011-0026-1
4
Phase sensitive detection for optical sensing with
porous silicon
Jesús Álvarez
(UVEG)
IEEE Photonics V4 I3 IEEE New Jersey 2012 986-995,
10.1109/JPHOT.2012.2201461
5
Biocompatible 'Click' Wafer Bonding for
Microfluidic Devices
Farizah Saharil
(KTH)
Lab on Chip V12 RSC London 2012 pp3032-3035,10.1039/C2L
C21098C
6
Dry adhesive bonding of nanoporous inorganic
membranes to microfluidic devices using the
OSTE(+) dual-cure
Farizah Saharil
(KTH)
Journal of Micromechanics
and Microengineering
V23 IOP London 2013 pp1-8, 10.1088/0960-
1317/23/2/025021
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polymer
7
Universal hydrophilic coating of thermoplastic
polymers currently used in microfluidics
Caterina Zilio
(CNR)
Journal of Biomedical
Microdevices
NA Springer New York 2014 pp107-114, 10.1007/s10544-
013-9810-8.
8
Real-time polarimetric optical sensor using
macroporous alumina membranes
Jesús Álvarez
(UVEG)
Journal of Optics Letters,
38 OSA Washington 2013 pp 1058-1060,
10.1364/OL.38.001058
9
Self detachment of free-standing porous silicon
membranes in moderately doped n-type silicon
Neeraj Kumar
(UNITN)
Applied Physics A NA Springer New York 2013 (online)
10.1007/s00339-013-8104-6
10
Allergen immobilization and signal amplification by quantum dots for use in a biosensor assay of IgE in
serum.
Geoff Platt
(Farfield)
Journal of Biosensors and bioelectronics
V52 Elsevier Amsterdam 2014 pp82-88
10.1016/j.bios.2013.08.019
11
Characterisation of porous alumina membranes for efficient, real-time, flow
through biosensing
Jesús Álvarez
(UVEG)
Analytica Chimica Acta
NA NA NA Under review
NA
12
Real time optical immunosensing with flow through porous alumina membranes
Jesús Álvarez
(UVEG)
Sensors and actuators B
NA NA NA Under review
NA
13
Investigation of non specific signal in nanoporous flow through and flow over sensors
Neeraj Kumar
(UNITN)
Analyst 139 Royal Soc. Of Chem.
NA 2014 pp1345-1349, 10.1039/c3an0199
6a
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2.6 Internal dissemination
Since there was a common knowledge basis on the critical issues, in order to greatly facilitate the final device integration the distribution of interdisciplinary knowledge was encouraged. This was done by taking advantage of the possibilities for internal dissemination such as introductory sessions for new PhD students and postdocs from the consortium partners at meetings and permitting short stays at one or two other partners. Most of the partners were already involved in EU networks of excellence where exchanges of students and postdocs take place. Furthermore, results can be used in educational activities such as courses, M.Sc. and Ph.D. projects. Previous participation in EU-projects has clearly shown that such participation enhances the quality of the educated candidates to world-class level.
Specifically we planned a series of 60-90 minute lectures to be held at each consortium meetings. The lectures contained a basic introduction in each of the many scientific and technical fields addressed within Positive. The target audience was the Positive partners themselves AND interested researchers at the site of the meeting.
Table: Positive internal lectures (typ. 60 - 90 minutes)
Date Lecture title Positive partners
13/09/10 Food allergies and currently available diagnostic tests
Kirsten Beyer, C-UB
2/12/10 Porous Silicon: From fundamentals to applications Paolo Bettotti, UNITN
24/3/11 Photonic and plasmonic materials and their applications
Juan Martinez Pastor, UVEG
22/3/12 Integration of Materials and functions in microfluidic devices.
Marcella Chiari, CNR
18/7/13 Introduction to DPI and Analight applications Paul Coffey, Farfield
20/6/11 OSTE in microfluidics Tommy Haraldsson, KTH
2.7 Contributions to standards
Throughout the project where necessary the consortium contributed to national and/or international standards.
2.8 Contribution to policy developments
In the eventuality that the project would have significant impacts on research or research-based policy development at regional, national or European level such details and policy process have been detailed in the dissemination section of the periodic reports. The project manager channeled any technical achievements which would have a significant impact on the Integrated Research and Industrial Roadmap for European Nanotechnology through the Nanofutures key node group of Design, Modelling and Testing of Materials in which he actively participates.
2.9 Risk assessment and related communication strategy
Any potential risks (real or perceived) for society/citizens associated with the project and the communication strategy adopted in this regard was identified during the project and communicated to the corresponding group through the appropriate means.
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3 Conclusions
Dissemination of foreground through various means took place throughout the whole of the project generating interest from all sections of society and scientific bodies for further work, collaborations, consortium formations and recognition of the high academic value of the work of the EC funded project. All of the activities and their successes have been recorded in this report.