Oat® Cosmetics: Oat® COM Extruded Colloidal OatmealPrepared by Oat® Cosmetics
What is Colloidal Oatmeal?
• The finely milled whole oat kernel including the bran.
• The bran contains the majority of the active constituents of the oat kernel.
• Colloidal oatmeal is not a true colloid:- A colloid is a system in which finely divided particles are dispersed
within a continuous medium in a manner that prevents settlement.
• It is monographed in the US by FDA as a skin protectant
• In order to meet the requirements of the monograph it must meet the requirements of the USPC
Oat® COM- Colloidal Oatmeal Skin Care Benefits compared with..
OCCLUSIVE HUMECTANT BARRIER REPAIR ANTIOXIDANTS ANTI-
INFLAMMATORYANTI-
IRRITANT
COLLOIDAL OATMEAL
MACADAMIA NUT OIL
DIMETHICONE MINERAL OIL PETROLATUM HYALURONIC
ACID GLYCERIN
CERAMIDES CHOLESTEROL
Molecules in Oats
Oat Actives Activity Application
Avenanthramides• Anti-irritant and redness reduction (Anti-histamine
effect similar to Tranilast) • anti-oxidant activity (such as superoxide dismutase)
Soothe & relieve dry skin
Avenacins (Saponins)
• Anti-inflammatory and immuno-regulatory properties in the treatment of atopic dermatitis (AD). Skin cleansing properties through sebum
Flavonoids • Antioxidants (Anti-carcinogenic??) Anti-microbial
Simple & Complex Phenolics
• Antioxidants, Prevention of lipid peroxidation, anti-inflammatory? Anti-pruritic
eta-Glucan• Immuno – stimulant• Reduce fine lines and wrinkles• Hydrating agent
Skin MoisturiserWound Healing
Lipids/Oils • 65% triglyceride, Vitamin E, phospholipids.• Effective emulsifying and antioxidant activity
Replenish skin provide pH buffering Vitamin-E precursors
Starch • Adsorption and absorption properties• Physical barrier
Oat Peptides • Collagen and elastin promoters by stimulation of the fibroblasts.
Skin pH Buffering Maintains barrier integrity
Avenanthramides
• A group of 20-30 naturally occurring polyphenols found in oats (Avena sativa L.)
• Strong anti-oxidant properties• A powerful anti-inflammatory and anti-histamine• Reduces redness
Anti-irritant activity of avenanthramides. Erythema was calculated 24 hours after irritation with 1.5 minimal erythema dose UV light, with oat fractions diluted in 50% ethanol to a constant volume, relative to baseline.
Adapted with permission from Schmaus et al.
Range seen in product with Oat® COM 3-5% inclusion
Oat β-glucan
• Unbranched linear glucose polymer• 1 → 4 glycosidic links (x4)• 1 → 3 glycosidic links (x1)
O
H
HO
H
H
H
OH
H
O
OH
O
H
HH
O
H
O
OH
OH
HO
HO
H
HH
HO
H
O
OH
OH
H
O
H
HH H
O
OH
OH
HO
H
What is Oat® COM- Extruded Colloidal Oatmeal
• The high beta-glucan variety ‘Peppi’ is grown by selected farmers in Finland
• Manufactured by patented process resulting in:
• Optimised activity and functionality
• Excellent microbial purity
• Enhanced bioavailability of phytochemicals
• Enhanced rheological characteristics
• Very small particle size imparting excellent textural properties
• Effective lipid and water binding properties enhancing emulsion stability
Enhanced Colloidal Stability
• Non-extruded vs. Oat® Cosmetics Oat® COM
• 5% Suspension
• Centrifuged 3000rpm 10 min
Left: Competitor Colloidal OatmealRight: Oat® COM USP
Enhanced Colloidal Stability: Zeta Potential
• Oat® Cosmetics’ Oat® COM shows significantly higher Zeta potential, therefore presents enhanced stability over a wider range of temperatures and pHs
Zeta potential [mV] Stability behaviour of the colloid
from 0 to ±5, Rapid coagulation or flocculation
from ±10 to ±30 Incipient instability
from ±30 to ±40 Moderate stability
from ±40 to ±60 Good stability
more than ±61 Excellent stability
Zeta Potential: Standard Colloidal Oatmeal Zeta Potential: Oat COM USP
Enhanced availability of Oat β-Glucan
• Oat β-glucan is a key component of Oat® COM for cosmetic use
• The higher the Oat β-glucan content, the more effective your formulations will be at delivering these highly desirable results
• A higher oat β-glucan can be demonstrated by rheology.
Oat® COM [red] vs. Competitor Colloidal Oatmeal[black]
High Microbial Purity
Disinfectant chemicals Irradiation* Autoclaving UHT
InletMoisture
OutletMoisture
Water Activity
Microbescfu/g
Yeastcfu/g
Mouldscfu/g
Flour 13% 0.6 7 X 105 5400 730
Test 1 13% 7.5% 0.4 <10 <10 <10
Test 2 19% 12.2% 0.6 <10 <10 <10
Test 3 13% 7.2% 0.3 <10 <10 <10
Test 4 19% 11.9% 0.6 <10 <10 <10
• Note: when moisture of our oat flour is 7,5%, the water activity is about 0,45. When Aw is lower than 0,6 there is no microbe proliferation.
*Except Oat® COM IRR
Oat® COM Colloidal Oatmeal Oil Binding Capacity
Oil binding capacity:
• Oat® COM demonstrates an enhanced capacity to absorb and bind oil
Colloidal Oatmeal Weight increase (g) Average Weight Increase (g)
Average Oil binding (g/100g)
Standard 3.02 3.00
60
1.2 2.98
1.3 3.02
COM 3.91 3.89
78
2.2 3.92
2.3 3.9
Absorbs 30% more oil than standard colloidal oatmeal
Oat® COM Colloidal Oatmeal Oil Binding Capacity
How grea
sy or n
on-greas
y would yo
u rate
the crea
m during a
pplication?
How quickly
did the c
ream ab
sorb?
How greas
y or n
on-greas
y did yo
ur skin
feel
immed
iately
after
applica
tion?
How moist
urised
did your s
kin fe
el immed
iately
after
use?
How grea
sy or n
on-greas
y did yo
ur skin
feel 5
minutes
after
applica
tion?
How moist
urised
did your s
kin fe
el 5 m
inutes aft
er use?
How would you ra
te this p
roduct a
s a dail
y moist
uriser?
2.50
3.50
4.50
5.50
6.50
7.50
8.50
3.093.73 3.59
7.41
5.41
6.687.09
5.45 5.77 5.86
7.647.09 7.09
7.77
Short Term Placebo Double Blind Trial Results
Placebo averageTest averages
Aver
age
ratin
g be
twee
n 1
- 10
Extruded Colloidal Oatmeal 90 Day Trial - Methodology
• Independent consumer research facility conducted a single placement
study
• 53 female subjects all over 40 years old applied test cream once a day to
face
• 3 skin types equally represented, normal, dry and sensitive
• Assessed after 30, 60 and 90 days
Extruded Colloidal Oatmeal 90 Day Trial - Methodology
• Test cream was a market relevant passive base formulation with a 3% extruded Colloidal Oatmeal inclusion:
Trade Name INCI % w/w FunctionOat® COM Extruded
Colloidal OatmealAvena sativa Kernel Flour 3% Rheology, Emolient,
Active
Oat® Lipid e Avena sativa Kernel Oil 3% Emollient
Arlatone 2121 Sorbitan Stearate, Sucrose Cocoate 3% Emulsifier
Cetyl Alcohol Cetyl Alcohol 1% Co-emulsifier
WhiteParaffin Petrolatum 2.5% Emollient
Mineral Oil Paraffinum Liquidum 8% Emollient
Sunflower Oil Helianthus Annuus Seed Oil 3% Emollient
Sepigel 305 Polyacrylamide, C13-14 Isoparaffin, Laureth-7 2.5% Thickener, stabiliser
Neolone CapG Caprylyl Glycol, Methylisothiazolinone 1% Preservative
Purified Water Aqua to 100%
Extruded Colloidal Oatmeal 90 Day Trial – Overview of finds
Skin feeling moisturised Skin feeling silky soft Soothed the skin0%
10%20%30%40%50%60%70%80%90%
87% 83%
76%87% 83%
74%85% 74%
69%
Long Term Skin Trial Results Combined Cohort
30 Days60 Days90 Days
Perc
enta
ge o
f sub
ject
s tha
t 'ag
reed
'
Skin feeling moisturised Skin feeling silky soft Soothed the skin Nourishes the skin0%
10%20%30%40%50%60%70%80%90%
100%94% 100%
81%100%
100% 94%
94%94%
100% 80%
93%100%
Long Term Skin Trial Results Dry Skin Cohort
30 days60 Days90 Days
Perc
enta
ge o
f sub
ject
s tha
t'agr
eed'
Extruded Colloidal Oatmeal 90 Day Trial – Industry Reaction
Ed Galley at Ed Galley Associates
“The key result and one that in our opinion was very challenging across individuals with dry skin, was on-going and consistent moisturisation When subjects with dry skin conditions test moisturisers, we often expect to see good short-term observations, however long-term and sustained moisturising effects are rare. Dry skin conditions are often accompanied with related issues such as redness or flaking. Therefore the highly perceived soothing effects were also very encouraging indeed.”
Oat® COM Reparative Properties
Clinical Trial Reparative properties of Oat® COM
• In-vivo clinical trial
• Assessed skin barrier damage repair properties of Oat® COM
• Study carried out on 15 healthy adult subjects over a 10 day period
• Two skin areas on the volar forearms pre-irritated
• One area covered with an occlusive patch coated with 0.6% Oat® COM and the other an uncoated control
• Test sites were assessed at day 0, after 24 hours, 5 days
• Rate of recovery compared
Clinical Trial Test Results
Oat® COM patch
Control patch Oat® COM patch
Control patch Oat® COM patch
Control patch
Corneometer Tewameter Visual Grading Assessments
17.5 17.715.61 15.61
2.4 2.43
24.423.2
10.54 11.59
01.43
Results from corneometer, tewameter and visual grading assessments
1 5
Day
(g/h/m2)
Evaluates the water barrier function of the skin
(Visual grade units)
Visually evaluates and scores skin irritation
(Corneometer Units)
Determines the hydration levels of the skins surface
Clinical Trial Visual Assessment Grading Scale
Grade Unit Visual Assessment Grading Scale
0.0 No apparent cutaneous involvement
0.5 Faint, barely perceptible erythema or slight dryness (glazed appearance).
1.0 Faint but definite erythema, no eruptions or broken skin or No erythema but definite dryness; may have epidermal fissuring.
1.5 Well-defined erythema or faint erythema with definite dryness, may have epidermal fissuring.
2.0 Moderate erythema, may have a very few papules or Deep fissures, moderate-to-severe erythema in the cracks.
2.5Moderate erythema with barely perceptible oedema or severe erythema not involving a significant portion of the patch (halo effect around the edges), may have a few papules or moderate-to-severe erythema.
3.0 Severe erythema (beet redness), may have generalised papules or moderate-to-severe erythema with slight oedema (edges well defined by raising).
3.5 Moderate-to-severe erythema with moderate oedema (confined to patch area) or moderate-to-severe erythema with isolated eschar formations or vesicles.
4.0 Generalised vesicles or eschar formations or moderate-to-severe erythema and/or oedema extending beyond the area of the patch.
Clinical Trial Test conclusions
• Results confirmed Oat® COMs anti-irritant capability
• Showed Oat® COM supported the increased repair rate of the skin
• Oat® COM had statistically significant better recovery of – skin hydration – skin cracking – visual erythema
• Reparative properties caused by the interaction of the oat beta–glucan and anti-oxidants (Avenanthramides)
• Oat® COM’s patented process enhances the bio-availability of these molecules
Oat Sensitisation
Reports of Oat Sensitization
Study N Age Design Formulation Tests Results
Boussalt, 2007 1 302 • Prospective
• Open Oat pollen• APT• SPT• OFC• ROAT
15% APT+19% SPT+16% OFC+
7/25 ROAT+
Pigatto, 1997 2
42 (atopic)22 (control) 6-24 months • Double blind
• RandomizedColloidal oat
extract• Topical
applicationNo urticarial or contact allergy
reactions
Grimalt, 2007 3 173 (atopic) < 12 months • Open label
• 6 weeksOat-based emollient
• Steroid sparing effect
42% decrease in usage of moderate and high potency topical corticoids
Goujon, 2009 4 12 (atopic) Adults • Open label
• 45 days
Oat-containing
cosmetics and oat extracts
• APT• SPT• RMA
No immediate or delayed reactions
APT=atopy patch testing; OFC=oral food challenge; RMA-repeated and maximized applications; ROAT-repeated open application test; SPT=skin prick test.
1. Boussault P, et al. Allergy. 2007;62(11):1251-1257. 3. Grimalt R, et al. Dermatology. 2007;214(1):61-672. Pigatto P, et al. Am J Contact Dermat. 1997;8(4):207-209. 4. Goujon C, et al. Dermatology. 2009;218(4):327-333.
Source: AveenoMD
Topical Oat Safety
• Not common for food to cause disease flares in atopics
• Oats have not been reported as common offenders
• Studies of oat-based products applied topically show no tendency toward adverse events
• Safe and effective in the treatment of the vast majority of individuals
Source: AveenoMD
Oat® COM Summary
Benefits of our Unique Oat® COM – Colloidal Oatmeal
• Leaves luxurious silky feel on the skin
• Consumer trust in oats is at all time high
• Proven efficacy through independent skin trial
• Full traceability of ingredient from field to face
• Sustainable best agronomic practice / methods of farming
• Proven natural ingredient
Consumer Benefits of Oat® COM
• Recognised by the Food and Drugs Administration [FDA] as a skin protectant, ECOCERT and COSMOS certified
• Breadth of application in skin care & cosmetic products
• Proven efficacy in cosmetics and personal care products:- Moisturising- Cleansing- Anti-irritant- Anti-itch- Anti-inflammatory- Humectant- Occlusive - Antioxidant - pH buffering properties
Angus RobertsonBusiness Development
Oat Cosmetics02380 767 [email protected]