2002 Pyrazine derivatives

Pyrazine derivativesR 0550 Non-covalent Thrombin Inhibitors Featuring P3-Heterocycles with P1-Bicyclic

Arginine Surrogates. — The title compounds, e.g. (I), are potent and selective inhib-itors with excellent pK properties. — (SEMPLE*, J. E.; et al.; Bioorg. Med. Chem. Lett. 12 (2002) 20, 2925-2930; Dep. Med. Chem., Corvas Int., Inc., San Diego, CA 92121, USA; Eng.) — K. Schneider

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