Download ppt - Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power

Transcript
Page 1: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 2: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 3: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 4: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 5: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 6: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 7: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 8: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 9: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 10: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 11: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 12: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 13: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 14: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power
Page 15: Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power

Recommended

The Value of PCSK9 Inhibitors: A Matter of Perspective€¦ · Autosomal dominant inheritance pattern 2. Most mutations occur in the LDL-receptor gene—on chromosome 19 3. Mutations
The Value of PCSK9 Inhibitors: A Matter of Perspective€¦ · Autosomal dominant inheritance pattern 2. Most mutations occur in the LDL-receptor gene—on chromosome 19 3. Mutations Documents
PCSK9 Inhibitors, The Most Significant Advance in Lipid ...Wilson PCSK9 Inhibitors 25 of the first PCSK9 inhibitors in 2015, Repatha (evolocumab) and Praluent (alirocumab) both indicated
PCSK9 Inhibitors, The Most Significant Advance in Lipid ...Wilson PCSK9 Inhibitors 25 of the first PCSK9 inhibitors in 2015, Repatha (evolocumab) and Praluent (alirocumab) both indicated Documents
The Chronicles of Berberineassets.a4m.com/assets/webcasts/webcast_pdfs/2013-11-18...2013/11/18  · THE CHRONICLES of BERBERINE C. S. Lewis and R. H. Poling PCSK9, AMPK, and the LDL
The Chronicles of Berberineassets.a4m.com/assets/webcasts/webcast_pdfs/2013-11-18...2013/11/18  · THE CHRONICLES of BERBERINE C. S. Lewis and R. H. Poling PCSK9, AMPK, and the LDL Documents
Lipid lowering with PCSK9 inhibitors · 2015-01-30 · Phase III trials of PCSK9 inhibitors are providing evidence on the benefit of additional LDL -C lowering in high-risk patients
Lipid lowering with PCSK9 inhibitors · 2015-01-30 · Phase III trials of PCSK9 inhibitors are providing evidence on the benefit of additional LDL -C lowering in high-risk patients Documents
La Nuova Terapia...LDLR PCSK9 1. Catalytic domain 2. Prodomain 3. C-terminus PCSK9 is a Regulator of LDL Metabolism • Proprotein convertase subtilisin/kexin type 9 • A serine proprotein
La Nuova Terapia...LDLR PCSK9 1. Catalytic domain 2. Prodomain 3. C-terminus PCSK9 is a Regulator of LDL Metabolism • Proprotein convertase subtilisin/kexin type 9 • A serine proprotein Documents
PCSK9 Inhibitors
PCSK9 Inhibitors Documents
NEW DRUGS IN CARDIOLOGY PCSK9 INHIBITORS · • Discovery reported in 2003 and 2004 • PCSK9 missense/LOF mutations- ARIC study • African Americans : 28% less LDL-C, 88% lower
NEW DRUGS IN CARDIOLOGY PCSK9 INHIBITORS · • Discovery reported in 2003 and 2004 • PCSK9 missense/LOF mutations- ARIC study • African Americans : 28% less LDL-C, 88% lower Documents
Genetic determinants of lipids: concordance and discordance ......Loss-of-Function PCSK9 Mutations in AA Are Associated with Low LDL-C and Low Prevalence of CHD Events Adapted from
Genetic determinants of lipids: concordance and discordance ......Loss-of-Function PCSK9 Mutations in AA Are Associated with Low LDL-C and Low Prevalence of CHD Events Adapted from Documents
Rosuvastatin, pcsk9 concentrations, and ldl cholesterol response the jupiter trial
Rosuvastatin, pcsk9 concentrations, and ldl cholesterol response the jupiter trial Business
THERAPEUTICS A tale of two drugs - media.nature.com · cholesterol by liver cells, such that lowering PCSK9 expression reduces LDL cholesterol levels in the blood (high LDL levels
THERAPEUTICS A tale of two drugs - media.nature.com · cholesterol by liver cells, such that lowering PCSK9 expression reduces LDL cholesterol levels in the blood (high LDL levels Documents
Fetal gender and gestational age differentially affect ...intrauterine growth restriction (IUGR). Generally, LDL-C catabolism is under control of PCSK9 by binding to the LDL-receptor
Fetal gender and gestational age differentially affect ...intrauterine growth restriction (IUGR). Generally, LDL-C catabolism is under control of PCSK9 by binding to the LDL-receptor Documents
LODOCO Colchocine Research - ACRA · 2017-11-26 · The PCSK9 Trials will determine if there is a limit to the benefits of lowering LDL . The Current Paradigm for 2o Prevention of
LODOCO Colchocine Research - ACRA · 2017-11-26 · The PCSK9 Trials will determine if there is a limit to the benefits of lowering LDL . The Current Paradigm for 2o Prevention of Documents
The Role of PCSK9 in the Regulation of LDL Cholesterol · 2020. 7. 10. · surface, PCSK9 reduces the concentration of LDLRs on the surface of the hepatocytes, resulting in a lower
The Role of PCSK9 in the Regulation of LDL Cholesterol · 2020. 7. 10. · surface, PCSK9 reduces the concentration of LDLRs on the surface of the hepatocytes, resulting in a lower Documents
PCSK9 Dominant Negative Mutant Results in Increased LDL ... · CEA, Gif sur Yvette, France; APHP, Hoˆpital Saint-Antoine, Biochimie B, Laboratoire de Re´fe´rence pour le Diagnostic
PCSK9 Dominant Negative Mutant Results in Increased LDL ... · CEA, Gif sur Yvette, France; APHP, Hoˆpital Saint-Antoine, Biochimie B, Laboratoire de Re´fe´rence pour le Diagnostic Documents
PowerPoint Presentation€¦ · Angina pectoris Mutations in LDL receptor, apolipoprotein B or PCSK9 . 200 E 150 100 Homozygous FH Heterozygous FH Female sex Smoking Hypertension
PowerPoint Presentation€¦ · Angina pectoris Mutations in LDL receptor, apolipoprotein B or PCSK9 . 200 E 150 100 Homozygous FH Heterozygous FH Female sex Smoking Hypertension Documents
Pcsk9 inhibitory
Pcsk9 inhibitory Health & Medicine
Prevalence and relevance of Lp(a) in familial ... · Atherosclerosis Myocardial infarction Angina pectoris Elevated LDL cholesterol Mutations in LDL receptor, apolipoproteinB or PCSK9
Prevalence and relevance of Lp(a) in familial ... · Atherosclerosis Myocardial infarction Angina pectoris Elevated LDL cholesterol Mutations in LDL receptor, apolipoproteinB or PCSK9 Documents
PCSK9 Inhibition : From Genetics to Patients · PCSK9 mutations and impact on LDL-C\爀屲 PCSK9 mutations represent the major source of variability in PCSK9 expression. Two type\൳
PCSK9 Inhibition : From Genetics to Patients · PCSK9 mutations and impact on LDL-C\爀屲 PCSK9 mutations represent the major source of variability in PCSK9 expression. Two type\൳ Documents