PUBLIC
MEASUREMENT OF STRESS
CONNECTED HEALTH SOLUTIONS
STRESS
€ 514B IN EUROPE
STRESS PHYSIOLOGY
4
THE FLIGHT OR FIGHT RESPONSE
Jvnkfood, CC BY-SA
ACUTE STRESS | CHRONIC STRESS
5
STRESS CONTINUUM
No stress related
complaints
Stress related complaints
< 3months
No limitation in social/professional
functioning
Overstrain3-6 stress
related complaints
Burnout
>6 months stress related complaints
HOW TO MEASURE STRESS?
A VITAL SIGN
MONITOR
IN 1 CM3
A VITAL SIGN MONITOR IN A CM3
IMEC.MUSEIC V3
A VITAL SIGN
MONITOR
IN ONE SINGLE CHIP
WEARABLE
MEDICAL
DIAGNOSTICS
Printed disposable patch – reusable electronics
TAKING
HEALTH
MONITORING
TO
YOUR
CAR
NON-CONTACT SENSING - IN OFFICE / HOSPITAL ENVIRONMENT
CardiovascularRespiratory
Cuff-less
Blood Pressure monitoring
CHF
PATIENT
MANAGEMENT
Mobile Cardiac
Outpatient Telemetry
SLEEP APNEA
imec CONNECTED HEALTH SOLUTIONSTOOLS FOR DIAGNOSTICS AND DISEASE MANAGEMENT
Nephrology
imec CONNECTED HEALTH SOLUTIONSTOOLS FOR DIAGNOSTICS AND DISEASE MANAGEMENT
NeurologyOphthalmology
Surface EEG
monitoring
Multifocal
contact lenses
(presbyopia)
BCI & NeurofeedbackGastroenterology
Orthopedics
AUGMENTED REALITY
ENHANCEMENTS
CONNECTED HEALTH SOLUTIONSCREATION OF INVESTIGATIONAL DEVICES –WITH ACCESS TO RAW DATA
Neurology
Nephrology
CardiologyPneumonology
Gastroenterology
Ophthalmology
Mental health
Orthopedics
imec CONNECTED HEALTH SOLUTIONSCOLLABORATION WITH CLINICAL PARTNERS
Neurology
Nephrology
CardiologyRespiratory
Gastroenterology
Ophthalmology
Mental health
Orthopedics
IMEC.ICHANGE
▪ PERSONALIZED ALGORITHMS TO CAPTURE BEHAVIORS
▪ INSIGHT IN OBJECTIVE AND SUBJECTIVE BEHAVIORS, MENTAL STATUS
▪ JUST-IN-TIME FEEDBACK
17
DEVELOPMENT OF PERSONALIZED TOOLS FOR COACHING PROGRAMS /
PRECISION MEDICINE / DISEASE PREVENTION
CONFIDENTIAL8
DIGITAL PHENOTYPE
For increased
PERSONALIZATION and
BEHAVIOR change
SENSOR DATA FUSIONCOMBINING MEDICAL GRADE INVESTIGATIONAL DEVICES AND CONTEXTUAL
DEVICES
Gyroscope
PERSONALIZED AND
GENERALIZED SOLUTIONS:
• PHYSIOLOGY-BASED
• MOBILE-BASED
• HYBRID
CORRELATIONS AND
CAUSALITY ANALYSIS:
• DATA MINING
• UNSUPERVISED AND SUPERVISED ML
• TIME SERIES ANALYSIS
Digital
PhenotypingPersonas/Day
types/
Routines/Triggers/
Anomalies/
context
Demographics
Activity
Diet
Genetics
Technology Usage
Others...
In traffic
@work
Clinical
Stress
detection
Quality
indicators
PPG
EEG
ECG
Others...
Energy
expenditure
Cardio
respiratory
fitness
Activity
recognition
Daily Living
Clinical
Sport
DIGITAL PHENOTYPING
TOOLBOXES
Sport
Clinical
Daily living
Daily Living
Clinical
Sport
20
HUMAN CENTERED DESIGNFOR BEHAVIOR CHANGE
INTERVENTIONS
APP IMPLEMENTATION
AND STORAGEINFRASTRUCTURE
DIGITAL PHENOTYPING DEDICATED TRIALS
ENABLING SENSOR TECHNOLOGIES
BUSINESS MODELING
AN ITERATIVE INTERDISCIPLINARY PROCESS TOWARDS
BEHAVIOR CHANGE APPLICATIONS
IMEC.ICHANGE
21
BUILDING ON IMEC HARDWARE & SOFTWARE & LIVING LABS SKILLS
Technology track
User Needs
Application track
User
interaction(MICT, SMIT,
MintLab, APT)
Business
modeling(SMIT)
Personal
digital
Phenotyping(CHS, IBCN,
EXASCIENCE) Sensing
Innovations(CHS,
STADIUS,
IBCN, CMST)Living labs &
Trials (LL,
APT, SMIT,
CHS, MICT)
Behavior
change
application(CHS, IBCN,
SMIT,
MICT,APT )Stress
Management (CHS, IBCN)
Data backend
infrastructure(APT,
EXASCIENCE)
Wearable
Validation
Lab (CHS, LL, )
STRESS MEASUREMENT
SWEET STUDY: STRESS IN THE WORK ENVIRONMENT
23
WEARABLE AND CONTEXTUAL INFORMATION FOR STRESS DETECTION
23
CHEST PATCH
ECG
Acceleration (3 dim)
QUESTIONNAIRES
Stress
Activity
Food/beverage intake
Sleep
Gastro-intestinal symptoms
LOCATION
Continuous
During questionnaires
VOICE PHONE DATA
Proximity
Acceleration
Step count
Screen on/off
Ambient light
Temperature
Humidity
...
WEARABLES SMARTPHONE DEMOGRAPHICS
CHILLBAND
Skin conductance (SC)
Skin temperature
Acceleration (3 dim)
QUESTIONNAIRE
Age
Profession
Height
Weight
...
24
SOME SWEET NUMBERS
25
1,002 SUBJECTS 11 COMPANIES
23,500 SELF-REPORTED STRESS
RESPONSES
5 TB DATA
120,000 HOURS PHYSIOLOGICAL DATA
HOW TO PROCESS 120,000 HOURS OF PHYSIOLOGICAL DATA
RELATED TO MENTAL STRESSEC
GSC
Time
RAW DATA HIGH QUALITY DATA FEATURES
Time
Hear
tra
te(b
pm
)M
ean
SC (
µS)
Time
EC
GSC
GENDER SPORTS
DIGITAL PHENOTYPINGPERCEIVED STRESS ASSESSED BY QUESTIONNAIRE
POPULATION DYNAMICS
Medication Weekly sports hours
LINKING LIFESTYLE AND PHYSIOLOGY
No sports
Regular sports
PERSONALIZED STRESS RESPONSES REQUIRE PERSONALIZED MODELS
30
PERSON B
Skin Conductance response to a
stress test
PERSON A
Skin Conductance response to a
stress test
Rest Control Stress Rest
Rest Control Stress Rest
IMEC DATA ANALYTICS ENABLES THE CREATION OF HEALTH ALGORITHMS:
PERSONALIZED STRESS DETECTION
Sta
ndar
diz
ed H
eart
Rate
feat
ure WORKDAY
WEEKEND
Time (h)
Time (h)
LOWprobability
HIGHprobability
LOW stress
HIGH stress
NO stress
LOW stress
HIGH stress
NO stress
HIGHprobability
LOWprobability
No stress
Light stress
High stress
Self-assessment
Algorithm prediction
PERSONALIZED STRESS DETECTION ALGORITHM
TASK‐INDUCED PSYCHOPHYSIOLOGICAL RESPONSES
20 healthy participants
12 participants with stress related complaints
measurement of galvanic skin response, heart rate, and skin temperature
33
COMPARISON PARTICIPANTS WITH STRESS RELATED COMPLAINTS AND WITHOUT
patient's autonomic nervous system responses to and recovery from an acute stressor
TOWARDS INSIGHTS IN RISKS FOR BURNOUT & DEPRESSION
34
STRESS RESPONSE OF HEALTHY PERSONS VS PATIENT WITH CHRONIC STRESS
Skin Conductance stress response
35
Towards JUST-IN-TIME FEEDBACK at the
RIGHT PLACE and the RIGHT TIME
GO BEYOND MOTIVATION
36
1 .
2 .
3 .
4 .
HOW DIFFICULT IS • THE GOAL FOR YOU
• THE GOAL PERCEIVED BY YOU
FOCUS ON PERSONAL ABILITY
WHEN & WHERE SHOULD WE MOTIVATE YOU
ADD PERSONAL TRIGGERS
PERSONALIZATION
TODAY
Mister X
Demographics:
Weight: 60
Age: 38
Self-Perception:
Healthy[0,10]: 7
Sports: None
PERSONALIZATION
TOMORROW
DIGITAL PHENOTYPING
FOR
HYPER-PERSONALIZATION
45
WE ARE ALL DIFFERENT AND UNIQUE
STOP SMOKING EATING DISORDERS
+ MANY OTHER DIGITAL PHENOTYPING STUDIES
FOR CLINICAL PARTNERS START IN 2018( Borderline personality disorder, Chronic Depression, Assisted Living, Human-
Machine Interaction, prediction of injury, Stress resilience … )
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