LEARN WHAT WATERSLATEST INNOVATIVE MS TECHNOLOGIES

CAN DO FOR YOUWaters is proud to invite you to an open Waters Users Meeting to learn about our latest innovative technologies introduced at ASMS 2010, including the new Xevo™ high performance Benchtop MS Instruments based upon the Engineered Simplicity™ design approach with a unique workflow software solution for each application field.

The agenda will run on four parallel tracks focusing on: Biopharmaceutical, Clinical, Food & Environmental, and Pharmaceuticals.

This event will explore how innovative technologies and applications can increase your productivity and efficiency, including: • Stepwave™ technology for ultra high sensitivity MRM, • meeting the sensitivity challenges of dry blood spot analysis, • accurate mass for the qualitative and quantitative approach, • screening for residues; one UPLC®-MS dataset for the targeted and untargeted approach.

This meeting will give you the opportunity to talk to your colleagues and other experts, sharing opinions, experiences and ideas.

Feel free to forward this invitation to interested colleagues. Seats are limited though, so please register at www.waters.com/msdays now! We look forward to meeting you at one of our venues.

Mike van OosterhoutStrategic Markets ManagerWaters Corporation

© 2010 Waters Corporation. Waters, Xevo, Engineered Simplicity, Stepwave, UPLC and The Science of What’s Possible are trademarks of Waters Corporation.

UT RECHT – MONDAY, OCTOBER 11BRUSSELS – TUESDAY, OCTOBER 12FRANKFURT – THURSDAY, OCTOBER 14BASEL – FRIDAY, OCTOBER 15

BASEL, SWITZERLANDFRIDAY OCTOBER 15, 2010

09:00 Registration

09:30 Stepwave™: Ultra High Sensitivity MRM on the Xevo™ TQ-S David Little, Director - MS Product Management, Waters Corporation

10:00 Addressing the Sensitivity Challenges of Dry Blood Spot Analysis Jing Lin, Pharmaceutical Marketing Team Manager, Europe & India, Waters Corporation

10:30 Coffee Break

10:45 Accurate Mass for the Quantitative and Qualitative Approach enabled by Quantof™ Technology on the Xevo G2 QTof™ Mark McDowall, Strategic Development Manager, Waters Corporation

11:15 Residue Screening and Unknown Compound Discovery using MSE enabled UPLC®/QTof Timothy Jenkins, Business Operations Manager, Waters Corporation

11:45 Additional Innovations in Mass Spectrometry… and Related Techniques 2010 Mark McDowall, Strategic Development Manager, Waters Corporation

12:15 Lunch

13:30 Parallel Tracks

14:20 Coffee Break

14:45 Parallel Tracks

16:00 Closing Drinks

This event is FREE to attend. Accommodation and transportation to/from the hotel is the responsibility of the participant.

* See details on backpage.

© 2010 Waters Corporation. Waters, Stepwave, Xevo, QuanTof, QTof, UPLC and The Science of What’s Possible are trademarks of Waters Corporation.

BIOPHARMACEUT ICAL CLINICAL FOOD & ENV IRONMENTAL PHARMACEUT ICAL

Biopharmaceutical Analysis and the Waters Solutions

Alexander Muck Biopharmaceutical Specialist,

Central Europe, Waters Corporation

13:30 13:30 13:30 13:30Semi-Automated High Throughput Analysis Approach using the Tecan

EVO 100 and UPLC/MS/MS for 25-OH Vitamin D and Plasma Free

Metanephrines Peter Batjoens

Clinical Specialist, Waters Corporation

A Complementary Approach for the Analysis

of Pesticide Residues Dr. Andreas Tei

Waters Corporation

Metabolite Profiling using the GCT™ and the SYNAPT® G2

Endre Laczko Functional Genomic Cente,

UZH / ETHZ, Zürich

A Small Molecule Sample Profiling Strategy

using UPLC/oa-TOF MSE/Ion Mobility MS as the Analytical Tool

Richard Lock Manager HRMS System Support

Group, Waters Corporation

Combined Ion Mobility Mass Spectrometry for Metabolite

Characterization Frederic Lozach

DMP Biotransformation, Novartis Pharma AG, Basel

Development of a Lipidomic Platform Based on a Hybrid Quadrupole Time-

of-Flight (QTof) Ion-Mobility Mass Spectrometer for both Targeted and

non-Targeted Analysis Richard Lock

Manager HRMS System Support Group, Waters Corporation

False Positive and False Negative Results Dr. Anton Kaufmann

Kantonales Labor Zürich

Sensitive Direct Injection Analysis of Environmental Water Samples

with UPLC® Xevo™ TQ-S David Little

Director - MS Product Management, Waters Corporation

Novel Applications of APGC Technology in Food and Environmental Analysis

Timothy Jenkins Business Operations Manager,

Waters Corporation

Screening for Toxicologically Relevant Compounds – Toxicology

Screening using UPLC/MS/MS Dr. Markus Heck

Application Specialist, Waters AG Baden

Systematic Toxicological Screening using High Resolution Q-Tof

Technology and POSI±IVE Software Peter Batjoens

Clinical Specialist, Waters Corporation

Experiences with BiopharmaLynx™ in the Biopharma Industry Dr. Jörg Hörnschemeyer, Hoffmann-La Roche AG

HCP Analysis and HDX Applications in Biopharma

Scott Berger, Marketing Development Manager,

Waters Corporation

Characterisation of Glycoproteins by MS Methods

Dr. Luc-Alain Savoy M-Scan SA

ETD and HDMSE… Enabling Technologies for Biopharma

Mark McDowall Strategic Development Manager,

Waters Corporation

Peptides Quantification: One Step Beyond with Xevo TQ-S

Stéphane Canarelli Application Specialist,

Waters Corporation

The UPLC/MSE Workflow for Qualitative and Quantitative

Metabolite Identification Jing Lin

Pharmaceutical Marketing Team Manager,

Waters Corporation

© 2010 Waters Corporation. Waters, BiopharmaLynx, UPLC, Xevo, GCT, SYNAPT and The Science of What’s Possible are trademarks of Waters Corporation.Other trademarks are property of their respective owners.

WATERS MS TECHNOLOGY DAYS PARALLEL T RACKSBASEL, SWITZERLAND — FRIDAY OCTOBER 15, 2010

13:55 14:00 14:00 13:55

14:20 14:30 14:25 14:25

14:45 14:50 14:55

15:15 15:20

15:45