Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
1st International Affiliate of
1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
A Center at
VA Boston
2009 2010
International Affiliates
CIMIT: A formal consortium among 13 Boston institutions, MIMIT and A*Star Singapore
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
Joining Forces to Transform Healthcare
Drive innovation on the basis of unmet clinical need
Create technology innovation partnerships
Leverage of investment
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
MIMITTM - Innovation Development Pathway
Project Proposals
Industry Engagement
MIMIT Funding
Site Miner dialogue with
clinical community
Clinical Unmet Need
Industry targeted
scoping or other
introduction
Dissemination of need
To the widest group of scientists, engineers and designers.
Validation of need
Projectaward
Forum
Optional Industry
Funding or involvement
Best Ideas
Six month review Facilitated
Grant Funding
Other
Unmet Need Market Analysis Integration of need and solution Project DeliveryLicense/spin
out/other
Operational/ Management
team
Man
ch
este
r A
cad
em
ic H
ealt
h S
cie
nce C
en
tre
(MA
HS
C)
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
–Outputs• Identification and dissemination of existing
technology solutions• 22 unmet healthcare needs pump-primed• 3x leverage on initial investment (after 1 year)• Enhanced industry liaison opportunity• Longer term – patents / VC funding / licence
agreement / royalties– 1 project licence agreement and £5m VC funding
• Translational research opportunity / research outputs
• Optimised partnership opportunity
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
MIMIT workshops
MIMIT: CIMIT
Science Bridges award
Science Bridge Connections
University of Manchester
UHSM
CMFT Adults
CMFT Children’s
Tissue Engineering
Chemical Eng & cardiovascular Med
Pharmacy / biomaterials
Mathematics
The Christie
Wolfson Molecular Imaging/ neurology
Rehab Science
Plastic surgery
Respiratory medicine
Biomedical imaging
ENT
Anaesthetics
Paediatric oncology
Paediatric ICU
Neurology
Neonatology
Terenghi
Yuan
El-deredy
Parker
Lionheart
McCann
Oldham
McGrouther
Woodcock
Fowler
Herholz
Homer
Coleman
Makin
Playfor
Martland
Tirelli
Psychological Sciences
Electrical Eng.
Victor
MIT
Harvard Medical School
Draper Lab
Boston University
Brigham Women’s
Massachusetts General
Boston Children’s
Tissue EngineeringGuttag
Biomed Engineering
Radiology
Neurology
Biomedical Engineering
Rehabilitation Services
Pathology & Health Sciences
Laryngeal Surgery and Voice Rehab
Anaesthetics
Paediatric ICU
Grinstaff
Kikinis
Schacter
Trevejo
Borenstein
Zaman
Stevenson
Schoen
Hillman
Goldman
Wolf
Gaydecki
SRFTAdult ICU Dark
MIMIT workshops
Joint AHSC collaboration (via TTO’s) •Hospital Acquired Infection collaboration with the National Innovation Centre •Enhancing functional independence collaboration with Arthritis Research UK and the National Innovation Centre
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
Need unique to
organisation
Unmet need identified By 2-3 organisations
Universal unmet need
Retain exclusive rights to
innovate towards locally
Shared unmet needs with co rights to innovate to in collaboration
Scope unmet needs in agreed areas of mutual interest:Low probability of need
being universal
High probability of need
being universal •Collaboration to select preferred innovation target•Competition to find best solutions•Progress through jointly awarded funding initiatives or independently
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
‘Demand led’ opportunities:– Benefits to patients and clinicians by definition and
validation of unmet healthcare needs and a commitment to develop innovative solutions
– Best potential for development of good solutions by a wide scoping of expertise amongst organisations
– Best chance for success by selection of best projects
– Optimised leverage of investment to support innovation developments
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• World wide patents granted• SME collaboration FEMEDA• UMIP & TRUSTECH facilitated
licence agreement• >£5million venture capital
funded• Phase IV study complete• Global company expressions of
interest• >£200k industry sponsored
research funding• Bionow Healthcare Project of
the Year 2010• Sales commencing 2013
The need: Solving stress incontinence
The solution: Novel ‘tampon like’ pelvic floor muscle stimulator
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Funding leveraged £627k
including EPSRC and Williamson Trust
• Numerous conference presentations
• High impact publications• Patent protected• PhD studentships
awarded
The need: Reducing histopathological subjectivity in determining prostatic malignancy
The solution: Objective spectroscoping grading system for prostate cancer biopsies
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Patent filed • Funding leveraged £595k
including Medical Futures grant, NIHR i4i, UMIP PoP
• Numerous high impact publications
• PhD studentship funded (Newby Trust)
• Clinical trials underway
The need: Surgical repair of severed peripheral nerves
The solution: Novel fabricated polymer peripheral nerve conduits
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Novel microgel and
testing models developed• Funding leveraged £215k
(EPSRC)• PhD studentship• Patent protected• Numerous high impact
publications
The need: Replacement for degenerate intervertebral discs to treat low back pain
The solution: New biomaterials for regeneration of degenerate intevertebral disc
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Prototype developed &
undergoing clinical evaluation • Funding leveraged £664k
(Wellcome Trust, EPSRC, UMIP, MIMIT Science Bridges)
• UMIP PoP funding awarded• Patents filed and granted (UK,
EU & US) • Numerous publications &
international conference presentations / plenary
The need: Treatment for chronic pain hampered by lack of knowledge of the brains' response (fEITER)
The solution: Real time pain assessment using electrical impedance tomography (EIT)
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Patents filed• UMIP PoP funding
awarded £80k • RCUK Science Bridges
award £100k• Industry collaboration
The need: Point of care testing for respiratory disease
The solution: Novel breath collection device and identification of pathogen specific biomarkers
2008
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Prototype developed• Clinical testing underway• Further support from
TRUSTECH• Funding leveraged £43k
MRC Interdisciplinary Award
The need: Difficult to monitor compliance with knee exercises in the home
The solution: Compliance monitoring device
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Collaboration established
with Boston Children’s Hospital
• £50k Science Bridges award
• Animal studies underway
The need: Reducing ventilator-associated lung injury
The solution: Continuous non-invasive image guidance at the bedside
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Collaboration established with
Harvard Medical School / Brigham & Women’s and £50k Science Bridges award
• UK collaboration with Imperial College London and the Walton Centre NHS Foundation Trust, Liverpool
• £603k funding leveraged including Astro Fund
• Tracer markers identified & absract accepted British Neuro-oncology Society Annual meeting 2012
•
The need: Difficult to visualise glioma tumour margins when operating
The solution: Using PET and diffusion weighted MRI in the operating room to facilitate glioma tumour management
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
The outputs:• Collaboration established
with Harvard Medical School & Brigham & Women’s,
• £100k Science Bridges award made
• Phantom studies complete
• Ethical approval for human pilot granted
The need: Difficulty with functional imaging of the lung
The solution: Fusion of EIT and MRI data of the lung
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
Acknowledgments
Manchester Academic Health Science Centre (MAHSC)
National Innovation Centre
Joining forces to identify and address unmet clinical need through technology innovation
Copyright 2009 Property of MIMIT
1st International Affiliate of