Ischemia-Reperfusion

SyndromeBy

Momen Ali Khan

Definition

Restoration of blood flow to ischemic tissues can promote recovery of cells if they are reversibly injured, but can also paradoxically exacerbate the injury and cause cell death.

Systemic hypoperfusion causes-Tissue hypoxia Local activation of inflammation

These two effects leads to cellular and organ damage

Cellular and organ damage causes

Acid and potassium loadActivation of cellular and humoral

complement by hypoxia

Cellular and humoral component-

ComplementNeutrophilMicrovascular thrombi

Reperfusion

When circulation established flushing back of cellular and humoral component as well as acid and potassium load into blood .

Effects

Cellular and humoral component effect Acute lung injuryAcute renal injuryMultiple organ failure and death

Effects (contd’)

Effects of acid and potassium loadMyocardial depressionVasodilatation Further hypotension

Attenuation of reperfusion injury

Reducing the extent and duration of tissue hypoperfusion by appropriate management .

References