i Journal d Cerebral Circulation

MEDICAL LIBRARYVA CENTER

Wilmington, Delaware

zJln Official iJburnalofthe^

(^American Heart"a/lssociation, Inc.

VOLUME 10 NUMBER 6

NOVEMBER-DECEMBER 1979

(Volume Index In This Issue)

lschemic Cerebral Edema. A Review 623M D O'Brien

Prostaglandin I2 and Idomethacin Prevent Im-pairment of Post-lschemic Brain Reperfusionin the Dog 629

John M. Hallenbeck and Thomas W. Furlow, Jr.Prevention of Experimental Subarachnoid Hem-

orrhage-Induced Intracranial Arterial Vaso-necrosis with Phosphodiesterase InhibitorPhthalazinol(EG-626) 638

John F. Alksne and P. Josephine BransonAttenuation of lschemic Brain Edema by Pento-

barbital after Carotid Ligation in the Gerbil 644Pablo Lawner, John Laurent, Frederick Simeone,

Eugene Fink, and Elliot RubinBarbiturates in Focal Ischemia of Primate Cor-

tex: Effects on Blood Flow Distribution,Evoked Potential and Extracellular Potassium 647

Neil M. Brans ton. Terence Hope, andLindsay Symon

Influence of Various Agents on the Developmentof Brain Edema in the Rat Following Micro-embolism. Protective Effect of Gamma-Butyrolactone 653

Jean Bralet. Paulette Beley, Anne-Marie Bralel,end Alain Beley •»

Changing Pattern of Cerebral Infarction: 1945-1974 657

W. Michael Garraway, Jack P Whisnant,Leonard T. Kurland, and W. Michael O'Fallon

Recovery in Treated Aphasia in the First YearPost-Stroke 663

Martha Taylor Sarno and Eric LevitaMassive Doses of Steroids in Cryogenic Cerebral

Injury and Edema 670Raymond A. Clasen. Sylvia Pandolfi,

and Jaclynn R. ClasenHistopathological Reactivity of Carotid Arteries

of Normotensive Sprague-Dawley vs Spon-taneously Hypertensive Rats to LigationInjury 674

Bernard C. Wexler

Intracranial Venous Thrombosis in YoungWomen 680

Bruno Estanol. Alejo Rodriguez, Guillermo Come,Jose Manuel Aleman, Mauro Loyo,and Javier Pizzuto

Levels in Stroke Patients of CFS Astroprotein,and Astrocyte-Specific Cerebroprotein 685

Toru Hayakawa. Yukitaka Ushio, Takesada Mori,Norio Arila, Toshiki Yoshimine,Yasulaka Maeda, Keiji Shimizu, andAkio Myoga

Measurement of Regional Brain Glucose Utiliza-tion In Vivo Using [2-MC] Glucose 690

Richard Hawkins, William K. Hass,and Joseph Ransohoff

Experimental Cerebral Vasospasm after Sub-arachnoid Hemorrhage. Participation ofAdrenergic Nerves in Cerebral Vessel Wall 703

Shunro Endo andjiro SuzukiEffects of Hemorrhagic Hypotension on the Cere-

bral Circulation. I. Cerebral Blood Flowand Pial Arteriolar Caliber 711

Eric T. MacKenzie, J. Keith Farrar,William Fitch, David I. Graham,Peter C. Gregory, and A. Murray Harper

Effects of Hemorrhagic Hypotension on theCerebral Circulation. II. ElectrocorticalFunction 719

Peter C. Gregory, Anne P. McGeorge,William Fitch, David I. Graham,Eric T. MacKenzie, and A. Murray Harper

Effects of Hemorrhagic Hypotension on theCerebral Circulation III. Neuropathology 724

David I. Graham, William Fitch,Eric T. MacKenzie. and A. Murray Harper

Correlated Electrical and Mechanical Responsesof Isolated Rabbit Pial Arteries to SomeVasoactive Drugs 727

N.A.T. Lusamvuku. R. Sercombe. P. Aubineau,and J. Seylaz

continued on back cover

SJCCA 10(11-12)623-761(1979)ISSN 0039 2499

Publication number is 878740

Effect of Phenobarbital on Cerebral Energy Stateand Metabolism. Enzymatic Activities . . . 733

G. Benzi, A. Agnoli. F. Dagani, S. Ruggieri.and R.F. Villa

Pharmacological Comparison of Isolated HumanCerebral and Digital Arteries 736

Gary A. Rose and Robert F. W. Moulds

Abstracts of Literature

Erratum 741

An Appreciation 742

LETTERS TO THE EDITOR: Death in EarlyStroke, Causes and Mechanisms 743

O. B White. J W. Korris. V. C. Hachinskiand A. Lewis

744

News from American Heart Association 762A

Volume Author Index 767

Volume Subject Index 770

UltrasonicStroke Screening

SystemDOPSCAN™ is an ultrasonic, Doppler, arterial scanningsystem for early detection of potential stroke conditions.

It provides a noninvasive evaluation of the carotidbifurcation and other peripheral arteries to indicate thelocation and severity of arterial insufficiency andplaquing. It is a valuable supplement to X-ray angiography.

The simplicity and safety permit a physician toeasily follow the process of plaquing or a patient'sprogress after arterial surgery.

The DOPSCAN™ system is unique in that it providesa set of permanent exam records consisting of:(1) Mapped image of the carotid bifurcation, (2) Stripchart recordings showing pulsatile velocity waveformsin forward or reverse flow, and (3) Magnetic taperecordings of the customary Doppler flow sounds,which present the flow information in aural form alongwith the operator's commentary.

FIFTHINTERNATIONALJOINT CONFERENGO N STROKE ANDCEREBRALCIRCULATIONFebruary 21-23 1980Dutch Inn Resort Hotel, Walt Disney World, Lake Buena Vista, Flori

The Stroke Council of theAmerican Heart Associationin association with the Cere-brovascular Surgery Sectionof the American Associationof Neurological Surgeons,The Canadian Stroke Societyof The Canadian Heart Foun-dation and The Society forVascular Surgery is pleasedto announce the 5th Interna-tional Joint Conference onStroke and Cerebral Circula-tion.

This is an open meeting,whose purpose is to providea common forum for the pre-sentation of material relatingto all aspects of cerebrovas-cular disease and the physi-ology and pathology of thecerebral circulation. Ab-stracts dealing with the clini-cal or experimental aspectsof the pathogenesis, diagno-sis, medical and surgicalmanagement of vascular dis-ease of the brain and spinalcord are welcome.

Physicians and investigatorsinterested in diseases of thecerebral circulation and thephysiology and pathologicalchanges in the cerebral cir-culation are encouraged tosubmit abstracts to the Pro-gram Committee for consid-eration to be presented atthat meeting. Abstracts ac-cepted for presentation willbe published in the January1980 issue of the journalStroke of the American HeartAssociation.

Guidelines and furthermotion may be obtainswriting: Administrator, Pgraduate Programs, Ancan Heart Association,Greenville Avenue, DallTexas 75231. Phone (2 V750-5441. Robert G. SielM.D. of the Mayo Clinicand J. Donald Easton, tof the University of Misscare serving as ConfererCo-Chairmen.

Hotel reservation cards will be mailedwith a letter confirming registration

American HeartAssociation