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Page 1: HF-ACTION

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HF-ACTION

• No difference in mortality/hospitalizations between the two arms (HR 0.93, 95% CI 0.84-1.02, p = 0.13). On adjustment for other prognostic factors, was ↓ in exercise training arm (p = 0.03)

• CV mortality & CV hospitalizations (p = 0.14), 6-minute walk distance similar, but peak VO2 higher in the exercise training arm

• Serious side effects similar between two arms

Trial design: Patients with symptomatic systolic CHF on optimal medical therapy were randomized to either exercise training or usual medical care. Clinical outcomes were compared at 3 years.

Results

Conclusions • Prescribed exercise training program in

patients with systolic CHF safe and effective, when added on to optimal medical therapy

• Strengthens current recommendations for exercise in CHF patients

O’Connor CM, et al. JAMA 2009;301:1439-50

(p = 0.26)

Exercise training(n = 1,159)

Usual care(n = 1,172)

(p < 0.0001)

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