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Page 1: glucose

glucose

pyruvate

ATP

ATPNADNADH

NAD

NA

PARP1

H+

H+

III

IIIIV

ADP ATPNAD

ADP

NADH

The role of PARP-1 in DNA-damage induced cell death(click here)

Genotoxic stress

PARP1

NMN

ATP

NMNAT

glucose

ATP

NADH

NAD

NA

PARP1

H+

H+

III

IIIIV

ADP ATP

NAD

ADP

NADH

PARP1

NMN

ATP

NMNAT

ATP

NAD

glucose

ATP

NADH

NAD

NA

PARP1

H+

H+

III

IIIIV

ADP ATP

NAD

ADP

NADH

PARP1

NMN

ATP

NMNAT

ATP

NAD

CELL NECROSIS

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