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FUNGAL CHITOSAN IN
MEDICAL TEXTILESBy
NISHI PANDEY-17 SUHASINI GANESH-30
PARAS KWATRA-18 SUKANYA G.NINAWE-31
POMI DANDAPAT-21 USHA NANDHINI.C-35
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MEDICAL TEXTILES
Medical textiles are the textile products and constructiofor medical applications.
Materials used include monofilament and multifilamenwoven, knitted, and nonwoven fabrics, and composite
There are mainly four classifications in medical textiles:
Health care and Hygiene medical textiles.
Non-implantable medical textiles.
Implantable medical textiles.
Extra corporeal devices.
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FIBRES IN MEDICAL TEXTILES
Commonly used natural fibres are cotton, silk and rege
cellulosic fibres (viscose rayon). Commonly used syntheinclude polyester, polyamide, polytetrafluoroethylene polypropylene, carbon, glass, and so on.
Biodegradable fibres include cotton, viscose rayon, popolyurethane, collagen, and alginate.
Non-biodegradable fibres include polyester (e.g. Dacr
polypropylene, PTFE, carbon etc.A variety of natural polymers such as collagen, alginatchitosan, etc have been found to be essential materialwound dressings.
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CHITIN
Chitin, poly (-(1-4)-N-acetyl-D-glucosamine), is a natural polmajor importance is the most abundant polymer after cellulo
Chitinoccurs in nature as ordered crystalline microfibrils formcomponentsin the exoskeleton of marine invertebrates arththe cell walls of fungi and yeast.
Depending on its source, chitin occurs as two allomorphs, naand forms. A third allomorph -chitin has also been describ
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CHITOSAN
Whenthe degree of deacetylation of chitin reaches about 5
becomes soluble in aqueous acidic media and is called chit
Chitosan is a linear polysaccharide consisting of -(1-4)-2-am-glucopyranose units.
Chitin are a renewable and inexpensive source of chitosan.
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PREPARATION AND PROPERTIES
Chitosan is commonly prepared by deacetylating a-ch50 % aqueous alkali at 100-160 C for a few hours.
Chitin and chitosan (CTS) are highly basic polysacchar
Their unique properties include polyoxysalt formation, afilms, chelate metal ions and optical structural charact
Chitosan, the deacetylated product of chitin, is solubleacids such as acetic acid, formic acid, etc.
The most accepted one is the interaction of the positi
CTS with the negatively charged residues at the cell sumany fungi and bacteria, which causes extensive cell salterations and alters cell wall permeability.
As a result, CTS inhibits the normal metabolism of micro and finally leads to the death of these cells.
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ADVANTAGES
BIOCOMPATABILITY
BIODEGRADABILITY
SAFE MATERIAL
ANTI-MICROBIAL ACTIVITY
ANALGETIC ACTIVITY
WOUND HEALING ACTIVITY
ANTI-TUMOR ACTIVITY
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PRODUCTION OF FUNGAL CHITO
SELECTION OF MICROBIAL SPECIES
GROWTH MEDIUM
SOLID STATE FERMENTATION
RECOVERY AND EXTRACTION
PURIFICATION AND DEACETYLATION
EVALUATION
APPLICATION
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13.3
17.4
14.2
18.5
0
2
4
6
8
10
12
14
16
18
20
21.4 22.0 23.2 24.2
Biomass(g/L)
Chitosan % Yield
Chitosan yield fromAspergillus niger
1785 at incubation period of 96h
&120h) For the stain of chitosan
niger 1785 strain we havculture media incubateand 120 hours.
CULTURE MEDIA-1 For 96 hours ,the biomass i
& the % yield for chitosan 21.4%.
For 120 hours, the biomassyield for chitosan is 22.0%
CULTUREMEDIA-2 For 96 hours the biomass in
the % yield for chitosan pro23.2%.
For 120 hours the biomass yield for chitosan is 24.2%
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GLOBAL CHITOSAN MARKET SHARE,BYPRODUCT SEGMENT(2013-2014)
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Global marketing of chitosan(metric tonnes
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BIOMEDICAL APPLICATIONS OF CHIT
Physical form
Applications
Solution Bacteriostatic agents
Homeostatic agents
Cosmetics
Gel Delivery vehicle
Spermicide
Powder Surgical glove powder
Enzyme immobilization
Film /membrane Dialysis membrane
Contact lensWound dressing
Sponge Mucosal haemostatic dressing
Wound dressing
Fibres Improvement of dyeability
Miscellaneous
Anticholesteremic materials
Antigastritis agents
Anticoagulants
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CHITOSAN AS FIBRES IN MEDICALTEXTILES
Woven, non-woven fabrics, and knitted fabrics derivedchitosan fibers are amenable for use as wound-face pragents, wound-healing protective agents, and as woufilling agents.
It can be made into strong fibers that may be used as material and as a wound dressing when chopped fibe
incorporated into non-woven matrix. Non-woven fabrics has excellent characteristics as an a
Also a suitable material for absorbable, flexible suture fcontact with bile, urine and pancreatic juices.
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Medical textile products in perc
Percentage
Surgical Dressing
Surgical sutures
Contact lens
Artificial implants
Disposables
Sanitary napkinsChitosan can be uproducts contribut80% of total produ
medical textiles.
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REFERENCES
A.J Rigby, S.C. Anand, A.R. Horrocks, J. Text.Inst. 88(1997) 83-93.
T.L. Vigo, Textile processing and properties: Preparation, Dyeing, Performance, Elsevier, London, 1994.
M. Levin, S.B. Sello, Functional finishes (Part A), Marcel Dekker, Ne
C.G. Daughton, T. Ternes, Environ. Health Perspect. 107 (1999) 90
T.L. Vigo, Advantages in antibacterial polymers and materials, inand bioactive polymers, Gabelein, C., (Eds) Plenum Press, New Y225-237.
Alternate to collagen: Synthesis of artificial collagen gels based opolymerisable collagen-mimetic peptides. Murugesan Muthu, SaTony Cass, MagdiYacoub.
Imperial College, London, England, United Kingdom 61.2.SafavieJuncker D. Microfluidics made of yarns and knots: from fundameto simple networks and operations. Lab Chip.2011;11:261824.
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THANK YOU