Funding in Health + Care Stra2fied Medicine Innova2on Pla:orm
Alasdair Gaw, Sophie Dale-‐Black Loic Lhuillier, Chris Rowe, Penny Wilson
Stratified Medicine Innovation Platform • Launched October 2010 • Accelerate Development and Uptake of Stra2fied Medicine
– Improve Pa2ent Outcomes – Provide Cost Benefit to the NHS and The Healthcare Industry – Deliver wider UK economic benefit
• Original Partners – Department of Health, ScoPsh Government Health Directorate – NICE, Medical Research Council, Technology Strategy Board – Arthri2s Research UK, Cancer Research UK
• Consulta2on and Advice – MHRA, NIHR
• The combined 5 year Investment amounts to £200 Million
Aligning investment to establish Stra2fied Medicine for improved pa2ent outcomes
Clinical need
Fundamental Science
Sustainable products and services
SMIP UK Roadmap Key Themes • Incen2vising adop2on • Increasing awareness • Pa2ent recruitment – consents and ethics
• Clinical trials • Data – collec2on, management and use
• Regula2on and standards • Intellectual property • Bio-‐banks and biomarkers
• Increasing the impact of R&D investment hYps://ktn.innovateuk.org/web/stra2fied-‐medicines-‐innova2on-‐
pla:orm
Potential partners across Diagnostic test commercialisation pathway
Proof of principle
Biomarker discovery Lab validaGon Clinical
validaGon Clinical uGlity
Market approval
Market uptake
Farr InsGtute CPRD
care,data Electronic Health Research Centres
Connected Digital Economy Catapult NHS InnovaGon
Monitor Academic Health Science
Networks (AHSNs) Regional/ local NHS
organisaGons
Health economic companies Product engineering companies Biomarker validaGon companies
Cell Therapy Catapult Medical Research Council
Genomics England Research chariGes
University Tech Transfer Offices
NICE MHRA EMEA FDA
NOCRI DiagnosGc Evidence CooperaGves
StraGfied Medicines Scotland InnovaGon Centre
Clinical Research Networks Contract research organisaGons
NIHR imaging centres Imanova
Royal Colleges of Medicine High-‐value Manufacturing Catapult
UK Biobank, Charity Biobanks,
Precision Medicine Catapult
Planning ahead to reduce time to commercialisation
Proof of principle
Biomarker discovery Lab validaGon Clinical
validaGon Clinical uGlity
Market approval
Market uptake
Who Pays? Why?
Whats the value?
Who Uses it? Where?
What is the evidence required?
NICE ScienGfic advice Programme: DAP
MTEP
MHRA
AHSN NHS InnovaGons
DiagnosGc evidence CooperaGves
Precision Medicine Catapult
• Addressing the leading healthcare challenges of the UK. • Aim to provide exemplars of working across UK landscape to reduce 2me to adop2on
• Linking companies with NIHR DECS, MRC Path Nodes, AHSN, Devolved government structures
• Drive adop2on by early involvement of partners and Proof of u2lity – Provision of economic models for NICE that support Stra2fied Medicine
StraGfied Medicine InnovaGon PlaUorm Round 6 StraGfied Medicine: Working with the UK Infrastructure SBRI: 2 phase competition: £10m
Potential partners across Diagnostic test commercialisation pathway
Proof of principle
Biomarker discovery Lab validaGon Clinical
validaGon Clinical uGlity
Market approval
Market uptake
Farr InsGtute CPRD
NICE MHRA
Catpults High-‐value Manufacturing
UK Biobank, Charity Biobanks,
Biomarker Research uniGs MRC NIHR etc
Genomics England
DECS (NIHR)
Diagnos2cs company
AHSN Innova2on leaders
Catapults Precision Medicine Catapult
• Phase 1 – Up to 9 months dura2on: – Objec2ve to provide health economic assessment of product and any early work to demonstrate feasibility of product/service technology • Amount available up to £150,000 per project Aim to provide exemplars of working across UK landscape to reduce 2me to adop2on
• At 9 months a report of the results and proposed value must be submiYed • Successful applicants may then apply for Phase 2 funding • Provisional dates
StraGfied Medicine InnovaGon PlaUorm Round 6 StraGfied Medicine: ConnecGng the UK Infrastructure SBRI: 2 phase competition: £10m
Competition opens 7 September 2015Briefing event 15 September 2015Registration deadline 28 October 2015 noonDeadline for applications 4 November 2015 noonContracts awarded 08 January 2016
• Phase 2 of the compe22on: £8 million – For projects up to 3 years dura2on: – Opens September 2016 – Successful applicants from Phase 1 only – Applicants will submit a full development plan up to commercialisa2on – Aher submission applicants will pitch to a board of assessors – Expecta2on of up to 4 projects being funded.
StraGfied Medicine InnovaGon PlaUorm Round 6 StraGfied Medicine: ConnecGng the UK Infrastructure SBRI: 2 phase competition: £10m
• Partnering Workshops – 4 workshops across the UK – Representa2ves of each na2ons organisa2ons will be present – Workshops dates are:
• Scotland: 22nd June, DoubleTree Hilton Edinburgh • Northern Ireland: 24th June, Titanic, Belfast • England: 30th June, ETC Farringdon London • Wales: 2nd July Life Sciences Hub Cardiff
StraGfied Medicine InnovaGon PlaUorm Round 6 StraGfied Medicine: ConnecGng the UK Infrastructure SBRI: 2 phase competition: £10m
For more information...
Innovate UK Web Page: www.innovateuk.org
Contact Alasdair Gaw: [email protected]
hYps://www.eventbrite.co.uk/e/stra2fied-‐medicines-‐diagnos2c-‐biomarker-‐approaches-‐opportuni2es-‐edinburgh-‐2ckets-‐17041945919 hYps://www.eventbrite.co.uk/e/stra2fied-‐medicines-‐diagnos2c-‐biomarker-‐approaches-‐opportuni2es-‐belfast-‐2ckets-‐17042016129 hYps://www.eventbrite.co.uk/e/stra2fied-‐medicines-‐diagnos2c-‐biomarker-‐approaches-‐opportuni2es-‐cardiff-‐2ckets-‐17042054243 hYps://www.eventbrite.co.uk/e/stra2fied-‐medicines-‐diagnos2c-‐biomarker-‐approaches-‐opportuni2es-‐london-‐2ckets-‐17042004093
WORKSHOP REGISTRATION LINKS
• Proposals that bring forward new modelling systems that: • Integrate healthcare and science data to predict the likelihood
– of a product demonstra2ng the intended effect in a clinical sePng – of demonstra2ng clinical u2lity.
• This will include systems biology and bioinforma2cs applica2ons
• Provide innova2ve mul2-‐parameter algorithms that enhance the predic2ve strength of a diagnos2c to allow regulatory acceptance and commercialisa2on
• Provide innova2ve Health economic models for products that will allow new clinical care pathways to be established
Knowledge Transfer Partnership Modelling for StraGfied Medicine £1m, project length 6months to 3 yrs