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Page 1: Figure 15.2 A Model Signal Transduction Pathway

Figure 15.2 A Model Signal Transduction Pathway

SignalSolutes enter the space betweenthe two membranes throughlarge pores in the outer membraneof E. coli.

EnvZ

ReceptorThe EnvZ membrane proteinchanges shape in response to thehigh solute concentration,catalyzing the addition of aphosphate from ATP.

TransductionThe phosphate from EnvZ istransferred to the OmpR protein…

…and the phosphorylatedOmpR changes shape,

enabling it to bind to DNAand stimulate transcriptionof the ompC gene.

OmpC protein inserts into theouter membrane, preventingsolute entry and keeping thecell’s exterior osmoticallybalanced.

Outermembraneof bacterium

Cellwall

Intermembranespace

Plasmamembrane

Pores

EnvironmentSolute

OmpR

ompCDNA

mRNA

OmpCprotein

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