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Chapter 5: Experimental Analysis
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Page 37
5. EXPERIMENTAL ANALYSIS
5.1 WEIGHT VARIATION
Weight of 20 Tablets = 6.5238 gm
Weight of each tablet
1. 325.5 mg 11. 326.7 mg
2. 327.3 mg 12. 324.5 mg
3. 323.5 mg (Min. weight) 13. 328.1 mg
4. 326.4 mg 14. 324.6 mg
5. 328.1 mg 15. 327.3 mg
6.
325.1 mg 16. 324.7 mg7. 329.5 mg (Max. weight) 17. 326.6 mg
8. 328.3 mg 18. 325.1 mg
9. 325.6 mg 19. 324.9 mg
10. 325.8 mg 20. 325.3 mg
Average weight 0f 20 Tablets = 326.19 mg
Maximum weight Variation = × 100
= + 1.01 % w/w
Maximum weight Variation = × 100
= 0.82 % w/w
329.5 326.19
326.19
329.19
323.5 326.19
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Chapter 5: Experimental Analysis
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5.2 ANALYSIS FRIABILITY TEST :- (NMT 1.0 %)
Weight of 20 tablet (w1) = 6.5643 gm
Weight of 20 tablet after round (w2) = 6.4386 gm
6.5643 - 6.4386
6.5643
= 0.019 % w/w
5.3 ANALYSIS DISSOLUTION TEST :- (NLT 75 %)
Claim of Tablet = 250 mg
I. Dissolution Ist
tablet
Weight of (sample) tablet = 325.2 mg weight of STD = 251.1 mg
Reading of Tablet =0.347 Reading of STD = 0.358
Dissolution = × × 325 ×
= 242.75 mg or 97.09 %
Friability =
0.347 251.1 99.8
0.358 325.2 100
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Chapter 5: Experimental Analysis
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Page 39
II. Dissolution IInd
tablet
Weight of (sample) tablet = 325.8 mg weight of STD = 251.1 mg
Reading of Tablet = 0.357 Reading of STD = 0.358
Dissolution = × × 325 ×
= 249.28 mg or 99.71 %
III. Dissolution IIIrd tablet
Weight of (sample) tablet = 325.7 mg weight of STD = 251.1 mg
Reading of Tablet = 0.342 Reading of STD = 0.358
Dissolution = × × 325 ×
= 238.88 mg or 95.55 %
0.357 251.1 99.8
0.358 325.8 100
0.342 251.1 99.8
0.358 325.7 100
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Chapter 5: Experimental Analysis
Analysis of -Lactam Anti-B iotics (Inhibitors of cell walls Synthesis)& It¶s Raw Materials As Penicillin V
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IV. Dissolution IVth
table
Weight of (sample) tablet = 325.1 mg weight of STD = 251.1 mg
Reading of Tablet = 0.342 Reading of STD = 0.358
Dissolution = × × 325 ×
= 239.32 mg or 95.73 %
5.4 DISINTEGRATION TIME :- (NMT 15 minutes)
Disintegration = 5.3 minutes
5.5 HARDNESS :- (NLT 3.0 kg/cm2)
Hardness = 6.5 kg/cm2
5.6 ASSAY :- (92.5% to 107.5%)
Area of STD (Phenoxymethylpenicillin Potassium) = 3301042
Area of Sample = 2850626
Weight of Sample = 325.8mg
Weight of STD (Phenoxymethylpenicillin Potassium) = 285.6 mg
Average weight = 325 mg
Drug label claim = 250 mg/tablet
0.342 251.1 99.8
0.358 325.1 100
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Chapter 5: Experimental Analysis
Analysis of -Lactam Anti-B iotics (Inhibitors of cell walls Synthesis)& It¶s Raw Materials As Penicillin V
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STD solution preparation
125 mg (Phenoxymethylpenicillin Potassium) 100 ml in diluents
(25 ppm) Make up 50 ml with diluents 1 ml
Test solution preparation
250 mg (Tablet sample) 100 ml in diluents
(25 ppm) Make up 100 ml with diluents 1 ml
Assay :
2850626 285.6 99.8
Test Area STD Weight 1 100 100 Potency
X X X X X X Avg. Weight
STD Area 100 50 Test Weight 1 100
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Chapter 5: Experimental Analysis
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Assay = × × 325 ×
= 245.53 mg /tablet or 98.21 %
3301042 325.8 100