SteriLUX® Filter Cartridge
The SteriLUX®hydrophilic PVDF membrane filter is ideal for sterile filtration,
prefiltration and clarification of pharmaceutical and biological solutions.
It has been optimized to sterile filter pharmaceutical preparations, active
ingredients, biopharmaceuticals, vaccines, serum and blood products,
parenterals, ophthalmics, orals, topicals, protein solutions, salts, buffers,
diluents, growth media, cell and tissue culture media and media additives.
SteriLUX®also provides high performance filtration of bulk pharmaceutical
chemicals, cosmetics and toiletries, diagnostics, solvents and solvent/product
mixtures, reagents and high purity water. SteriLUX® filters can also be used
for particulate removal and bioburden reduction in aqueous liquid streams.
The SteriLUX®membrane is surface-modified to provide immediate and
permanent water-wettability. It also provides high flow rates and long service
life. It features extremely low binding of proteins and preservatives. Integrity
testable, SteriLUX® offers the highest assurance of product integrity and
filtration performance.
Meissner Technical Services (MTS) offers thecomprehensive technical and validation supportthat is essential to our pharmaceutical clients.
Based on ASTM F838-05 liquid bacterial challenge testing, SteriLUX® is a sterilizing grade filter. Its inert PVDF membrane
and polypropylene components provide wide chemical compatibility and thermal stability, enabling effective use in a broad
range of fluids and applications. The SteriLUX® filter is offered with absolute ratings of 0.1 μm, 0.2 μm, 0.4 μm and 0.6 μm.SteriLUX®can be used to filter aqueous solutions and many high surface tension chemicals and solvents.
Design Features
•Modified PVDF membrane for inherent water wettability
•Extremely low protein and preservative binding for maximum product recovery
•Extremely low extractables
•Highest flow rate of any PVDF membrane filter
Typical Applications
SteriLUX®has been optimized for the sterile filtration of critical fluids used in
pharmaceutical and biopharmaceutical manufacturing, including:
•Parenterals
•Antibiotics
•Vaccines
•Diagnostics
•Buffers
•Diluents
•Reagents
•Serum
•Tissue culture media
•Media additives
SteriLUX®can be used for the clarification and purification of:
•Deionized water
•Aqueous solvents
•Acids
•Bases
•Plating solutions
Within the food and beverage industry, SteriLUX® can be used for clarification and
stabilization of fluids, such as:
•Beer
•Wine
•Bottled water
SteriLUX®SEM
Product Specifications
Materials of Construction
Filter Media: Polyvinylidene fluoride(PVDF)
Upstream Support: Polypropylene
Downstream Support: Polypropylene
Core/Outer Guard: Polypropylene
End Caps: Polypropylene
Sealing Method: Thermal bonding
Gaskets/O-rings: Buna, EPR, polyethylene, silicone,
Teflon®, Teflon®over silicone,
Teflon®over Viton®
All materials of construction listed above are FDA approved
for food contact use per 21 CFR 177. Filters comply with
European Commission Directive 2002/72/EC and subsequent
amendments up to Commission Regulation (EU) no 10/2011.
SteriLUX® filters are manufactured in conformance to cGMP.
SteriLUX® filters meet the requirements as specified in the
current USP Class VI plastics, physicochemical, oxidizable
substances, and cytotoxicity tests. Bacterial endotoxin
levels in aqueous extracts of SteriLUX® filters are less than
0.5 EU/mL, as determined using the Limulus amebocyte
lysate (LAL) test. No binders, adhesives or surfactants are
used in the construction of SteriLUX® filters. SteriLUX®
filters are non-fiber-releasing as defined in 21 CFR 210.3(b)(6)
and 211.72
Filtration Ratings
Absolute Ratings (µm)
0.1 μm, 0.2 μm, 0.4 μm and 0.6 μm
Integrity Testing
Minimum Bubble Point, Water
0.1 μm 70 psi (4,8 bar)
0.2 μm 50 psi (3,4 bar)
0.4 μm 28 psi (1,9 bar)
0.6 μm 14 psi (1,0 bar)
Cartridge Dimensions (nominal)
Diameter: 2.75" (7 cm)
Lengths: 10", 20", 30", 40" (25 cm, 50 cm, 75 cm, 100 cm)
Bacterial Retention
ASTM F838-05 Challenge:
VTH/VMH
0.1 μm, 0.2 μm > 107cfu/cm2Brevundimonas diminuta and
meet the FDA definition of a sterilizing grade filter.
0.1 μm ≥ 104cfu/cm2Acholeplasma laidlawii
0.4 μm > 107cfu/cm2Serratia marcescens
0.6 μm > 107cfu/cm2Saccharomyces cerevisiae
Sterilization
Steam-in-place (SIP):
Saturated steam @ 121-135 ˚C, 30-60 minutes[15 psi (1 bar) to 30 psi (2 bar), 30-60 minutes]
Autoclave: 121-135 ˚C, 30-60 minutes
SteriLUX®cartridges are capable of repeated sterilization
cycles without loss of integrity. For applications requiring
autoclave/SIP, a stainless steel reinforcement ring must
be ordered. See “Reinforcement Ring Option” within the
Ordering Information.
Maximum Operating Temperatures & Pressures
∆p 80 psi @ 32 °F to 100 °F
(∆p 5,5 bar @ 0 °C to 38°C)
∆p 60 psi @ 150 °F
(∆p 4,1 bar @ 66 °C)
∆p 30 psi @ 180 °F
(∆p 2,1 bar @ 82 °C)
Typical Water Flow Rates per 10" Cartridge
L min-1
0 5 10 15 20 25 30 35
10
9 0.1 µm
0.2 µm
8 0.4 µm
0.6 µm
7
6
5
4
600
500
400
300
3 200
2
100
1
0 0
0 1 2 3 4 5 6 7 8 9 10
Flow Rate, gpm
InitialDifferentialPressure,psid
∆p(mbar)
-226 O-ring -222 O-ring -226 nO-Ring® -222 nO-Ring®
SteriLUX® Filter Cartridge
End Cap Configuration
External -226 O-rings withlocking tabs; open end forC6
and F6 SOE configurations
External -222 O-rings;openend for C2 and F2 SOE
configurations
External -226 nO-Ring® withlocking tabs; open end forC5
and F5 SOE configurations
External -222 nO-Ring®, openend for C1 and F1 SOE
configurations
Flat Gasket Internal O-ring Button Cap Alignment Fin Recessed Cap
Flat Gasket; open end forGS
and GL DOE configurations
Internal O-ring; open end for
DN and DA DOE or RN andRA SOEconfigurations
Button Cap; closed endfor
C1, C2, C5 and C6 SOE
configurations
Alignment Fin; closed end for
F1, F2, F5 and F6 SOE
configurations
Recessed Cap; closed end for
RN and RA SOE configurations
Ordering Information
DOE = Double Open End
SOE = Single Open End
FilterGrade
AbsoluteRating (μm)
CartridgeLength
End CapConfiguration
ReinforcementRing Option
Seal Material(O-ring or Gasket)
VMH 0.2 3 F2 R
SIP applications
S
O-ring Seal
B = Buna
E = EPR
S = Silicone
T = Teflon®over silicone
V = Viton®
VLH = PVDF membrane;
not integrity tested
or flushed
(100 cm)F2 = SOE; -222 O-rings, fin end
C5 = SOE; -226 nO-Ring®, button cap end
C6 = SOE; -226 O-rings, button cap end
F5 = SOE; -226 nO-Ring®, fin end
F6 = SOE; -226 O-rings, fin end
DN = DOE; internal -120 O-rings
RN = SOE; internal -120 O-ring,
recessed cap end
DA = DOE; internal -213 O-rings
RA = SOE; internal -213 O-ring,
recessed cap end
X = Teflon®over Viton®
Gasket Seal
B = Buna
E = EPR
P = Polyethylene
S = Silicone
T = Teflon®
V = Viton®
Filter Grade Descriptions
VTH = This absolute, microbially rated filter meets full traceability requirements for the pharmaceutical industry. It is 100% integrity tested and flushed with DI
water during manufacture. Each VTH grade filter is shipped with a Certificate of Quality stating exact quality control criteria and test performance results. This is
a validatable product to meet the stringent requirements of the pharmaceutical industry.
VMH = This sterilizing grade filter is absolute, microbially rated and 100% integrity tested and flushed with DI water during manufacture. It is suited for critical
applications when regulatory documentation requirements are minimal. A Certificate of Conformance is available on a lot basis.
VLH = This filter is not 100% integrity tested or flushed with DI water during manufacture. It is offered as an economical prefilter or final filter when sterility
assurance and validation are not required.
Viton and Teflon are registered trademarks of E. I. du Pont de Nemours and Company
© 2013, 2003 Meissner Filtration Products, Inc. All rights reserved.
VMH 2.0
VTH = Certificated;
fully traceable
0.1 1 = 10"
(25 cm)
GS = DOE; flat gaskets
(9.75", 19.5", 29.25", 39" length filters)
(Blank) = Standard - no
reinforcement ring
PVDF membrane 0.2 2 = 20"
(50 cm)
GL = DOE; flat gaskets
(20", 30", 40" length filters) R = Reinforcement ring;
VMH = Standard 0.4 3 = 30" C1 = SOE; -222 nO-Ring®, button cap end required for autoclave/
PVDF membrane (75 cm) C2 = SOE; -222 O-rings, button cap end
0.6 4 = 40" F1 = SOE; -222 nO-Ring®, fin end
EverLUX® Filter Cartridge
The EverLUX® polyethersulfone (PES) f ilter is designed for very high contaminant capacity, ex tended
service life and high f low with low pressure drop in a wide range of biological f luids.
Opt im ized for ster ile f i lt rat ion, pref i lt rat ion and clar if icat ion applicat ions, the permanent ly
hydrophilic EverLUX® f ilt er of fers up to 2.5 t imes higher f low rates than other PES
membranes. It also offers except ional capacit y, low protein binding and absolutebacteria retent ion when f ilt ering moderate to high contaminant liquids.
The EverLUX® f ilt er incorporates the most technological ly advanced PES membrane
manufactured today. It is produced by a state-of-the art process, which creates a
unique, highly asymmet ric structure with the highest contaminant capacity of any
PES filter.
The membrane’s asymmetr ic structure ex tends its capacity and service life by withstanding
higher part icle loads and protein concentrat ions. Increased membrane thickness allows the
EverLUX® t o retain it s steril izing propert ies, while it s tapered pore st ructure allowsmore contaminant capacit y than even convent ional PES membranes.
The fast-f lowing, high-throughput, low-b ind ing and bacter ia-retent ive propert ies of the
EverLUX®PESmembrane make it avery reliable,cost -ef fect iveand t ime-saving filter.
De sig n Fe ature s and Be ne fits
• Unique, patented PES membrane offers very high f low rates
and except ional service life
• Chemical compat ibilit y across pH 1-14
• Low adsorpt ion, high transmission of proteins, act ive
ingredients and preservat ives
• Superior throughput in high contaminant f luids, including
growth media, serum and protein-containing solut ions
• Lower f ilt rat ion costs through increased service life and
contaminant -holding capacit y
• Permanent ly hydrophilic membrane
• Contains no binders, adhesives or other ex t raneous mater ials
• 100%integrit y tested during manufacture
• Biologically inert and non-toxic, the f ilt er meets FDA
requirements for food contact use and passes USPClass VI
Plast ics biological react ivit y tests
• Filters comply with European Commission Direct ive
2002/ 72/ EC and subsequent amendments up to 2008/ 39/ EC
Typical Applications
EverLUX® f ilt ers are ideal for use in arange of low to high
contaminant liquids, including:
• Blood products
• Complex biologicals
• Serum
• Cell and t issue culturemedia
• Process intermediates
• Supernatants
• Vaccines
• Ophthalmics
• Buffers
Meissner Technical Services (MTS)
provides cl ients with completetechnical and validat ion support
for i ts manufactured products.
Product Specif icat ions
Materials of Construction
Filter Membrane: Polyethersu lfone (PES)
Upst ream Support : Polypropylene
Downst ream Support : Polypropylene
Core/ Outer Guard: PolypropyleneEnd Caps: Polypropylene
Sealing Method: Thermal bonding
O-ring/ Gasket Seal: Buna, EPR, polyethylene, silicone,
Tef lon® over silicone, Tef lon® over Viton®
All materials of construct ion listed above are FDA approved
for food contact use per 21 CFR177. Filters comply
with European Commission Direct ive 2002/ 72/ EC and
subsequent amendments up to 2008/ 39/ EC.
EverLUX® f ilt ers are manufactured in conformance to
cGMP. EverLUX® f ilt ers meet the requirements as specif ied
in the current USP Class VI plast ics, physicochemical,
ox idizable substances, and cytotoxicit y tests. Bacterial
endotoxin levels in aqueous ext racts of EverLUX® f ilt ers
areless than 0.5 EU/ mL, asdetermined using theLimulus
amebocyte lysate (LAL) test . No binders, adhesives or
surfactants are used in the const ruct ion of EverLUX®
f ilt ers. EverLUX® f ilt ers are non-f iber-releasing as def ined
in 21 CFR 210.3(b)(6) and 211.72.
Filtration Ratings
Filter Grade: Absolute Rat ings (µm):
SMH 0.2, 0.4, 0.6
STW 0.2
SLH 0.2, 0.4, 0.6
SLW 0.2
SPH 0.1, 0.2, 0.4
Integrity Testing
Minimum Bubble Point , Water
SMH
0.2 µm 62 psi (4,3 bar)
0.4 µm 40 psi (2,8 bar)
0.6 µm 22 psi (1,5 bar)
Max imum Dif fusion Rate, Water
STW
0.2 µm 30 mL/ min per 10" @30 psi
(30 mL min-1 per 25 cm @ 2,07 bar)
EverLUX® SEM
2.5
2
1.5
1
0.5
0
Cartridge Dimensions (nominal)
Diameter: 2.75" (7 cm)
Lengths: 10", 20", 30", 40"
(25 cm, 50 cm, 75 cm, 100 cm)
Bacterial Retention
ASTM F838-05 Challenge
SMH
0.4 µm > 107 cfu/ cm² Serratia marcescens
0.6 µm > 107 cfu/ cm² Saccharomyces cerevisiae
STW
0.2 µm > 10 7cfu/ cm² Brevundimonasdiminutaand meets
the FDA def init ion of a steril izing grade f ilter.
Sterilization
Steam-in-place (SIP):
saturated steam @121-135 °C, 30-60 minutes
[15 psi (1bar) to 30 psi (2 bar), 30-60 minutes]
Autoclave: 121-135 °C, 30-60 minutes
EverLUX® cartr idges are capable of repeated steril izat ion
cycles without loss of integr ity. For applicat ions requiring
autoclave/ SIP, a stainless steel reinforcement ring mustbe ordered. See “Reinforcement Ring Opt ion” withinOrdering Information.
Maximum Operating Temperatures and Pressures
∆p 80 psi @32 °F to 100 °F
(∆p 5,5 bar @ 0 °C to 38 °C)
∆p 60 psi @ 150 °F
(∆p 4,1 bar @ 66 °C)
∆p 30 psi @ 180 °F
(∆p 2,1 bar @ 82 °C)
Typic a l Wa te r Flo w Ra te s pe r 10" C a rtridg e
Lm in -1
0 5 10 15 20 25 30 35
STW 0.2µm
0.2 µm
0.4 µm
0.6 µm
0 1 2 3 4 5 6 7 8 9 10
Flo w Ra te , g pm
160
140
120
100
80
60
40
20
0
Init
ial
Dif
fere
nti
al
Pre
ssu
re,
psid
p(m
ba
r)
- 226 O- ring - 222 O- ring - 226 nO- Ring - 222 nO- Ring
EverLUX® Filter Cartridge
End Cap Conf igurat ion
External -226 O-rings with
locking tabs; open end for C6
and F6 SOE configurations
External -222 O-rings; open
end for C2 and F2 SOE
configurations
External -226 nO-Ring® with
locking tabs; open end for C5
and F5 SOE configurations
External -222 nO-Ring®, open
end for C1 and F1 SOE
configurations
Flat Gaske t Inte rnal O- ring Butto n C a p Alig nm e nt Fin Re c e sse d Cap
Flat Gasket; open end for GS
and GL DOE configurations
Internal O-ring; open end for
DN and DA DOE or RN and
RA SOE configurations
Button Cap; closed end for
C1, C2, C5 and C6 SOE
configurations
Alignment Fin; closed end for
F1, F2, F5 and F6 SOE
configurations
Recessed Cap; closed end for
RN and RA SOE configurations
Ordering Information
DOE = Double Open EndSOE = Single Open End
FilterGrade
AbsoluteRating (μm)
CartridgeLength
End CapC o nfig ura tio n
ReinforcementRing Option
Seal Material(O-ring or Gasket)
SMH 0.2 3 F2 R S
SMH
STW
SLH
SLW
SPH
0.2, 0.4, 0.6
0.2
0.2, 0.4, 0.6
0.2
0.1, 0.2, 0.4
1 = 10"
(25 cm)
2 = 20"
(50 cm)
3 = 30"
(75 cm)
4 = 40"
(100 cm)
GS = DOE; flat gaskets
(9.75", 19.5", 29.25", 39" length filters)
GL = DOE; flat gaskets
(20", 30", 40" length fil ters)
C1 = SOE; -222 nO-Ring®, but ton cap end
C2 = SOE; -222 O-rings, but ton cap end
F1 = SOE; -222 nO-Ring®, f in end
F2 = SOE; -222 O-rings, f in end
C5 = SOE; -226 nO-Ring®, but ton cap end
C6 = SOE; -226 O-rings, but ton cap end
F5 = SOE; -226 nO-Ring®, f in end
F6 = SOE; -226 O-rings, f in end
(Blank) = Standard - no
reinforcement ring
R = Reinforcement ring;
required for autoclave/
SIP applicat ions
O-ring Seal
B = Buna
E = EPR
S = Silicone
T = Teflon® over sil icone
V = Viton®
X = Teflon® over Viton®
Gasket Seal
B = Buna
E = EPR
P = Polyethylene
Grade Descriptions
DN = DOE; internal -120 O-rings
RN = SOE; internal -120 O-rings,
recessed cap end
DA = DOE; internal -213 O-rings
RA = SOE; internal -213 O-rings,
recessed cap end
S = Silicone
T = Teflon®
V = Viton®
SMH = This standard , sing le layer PES mem brane featu res a high ly asymm et ric pore st ructu re. It is 100%in tegr i t y tested and flushed during manufactu re. It is su ited fo r cr i t ical app licat ionswhen regulatory documentation requirements are minimal.
STW = This pharmaceut ical val idated , steri l iz ing grade fi l t er featu res two ser ial ly layered , high ly asymm et ric PES mem branes with the coarser upst ream layer op t imized fo r pref i l t rat ion. Thisfi l t er meet s fu l l t raceab i l i t y requ irement s fo r the pharmaceut ical indust ry. Each STW fi l t er is shipped with a Cer t i f icate of Qual i t y stat ing exact qual i t y con t rol cr i t er ia and test per fo rm ance resu lt s.
SLH = This sing le layer PES mem brane featu res a high ly asymm et ric pore st ructu re, bu t is no t 100%in tegri t y tested or flushed dur ingmanufacture. It is offered as an economical pre-filter or final f iler when sterilit y assurance is not required.
SLW = This fi l t er featu res two ser ial ly layered , highly asymm et ric PES mem branes with the coarser upst ream layer op t imized fo rpref i l t rat ion . This fi l t er is no t 100%in tegri t y tested or flushed dur ing manufactu re. It is of fered as an econom ical pre-f i l t er or finalf ilter that provides longer life in biological solut ions.SPH = This is an absolute, part iculate rated filter. It is 100%integrit y tested and DI flushed during manufacture.
Vit on and Tef lon ar e registered tradem ar ks of DuPont Dow Elastom er s L.L.C. & The DuPont Com pany© 2011, 2003 Meissner Filt ration Products, Inc.
STyLUX® Filter Cartridge
The STyLUX® filter cartridge is an absolute rated, pleated polyethersulfone (PES) membrane filter designed to provide greater
bacteria and particle removal at high flow rates and extremely low pressure drops. It offers the greatest assurance of filtration
performance, stability and service life for controlling contaminants in demanding environments.
The exceptional performance of STyLUX® is derived from its unique filtration media.
The filter media is made by a patented process which produces an asymmetric
polyethersulfone membrane that is inherently hydrophilic. The membrane is a highly
porous structure whose pore size decreases progressively through its depth. This
highly durable structure maintains consistent porosity and contaminant retention
throughout its operational life without shedding or unloading particles. This results
in a filter that provides absolute retention and
superior flow rates, cleanliness and throughputs,
even in severe process conditions.
For applications requiring Mycoplasma removal,
Meissner offers the STyLUX®SC0.1 filter. This sterilizing
grade filter provides 100% retention of Mycoplasma per modified ASTM F838 Challenge,
while delivering the highest reliability and security for the sterilization of serum, culture
media and other biological fluids.
All components of the STyLUX® filter cartridge comply with FDA regulations
for food contact use. A unique state-of-the-art process thermally bonds
the membrane and polypropylene support components to the cartridge end
caps. This provides an integral filter cartridge that has excellent chemical
compatibility and extremely low extractables in a wide range of fluids and
applications.
Features and Benefits
•Durable PES and PP components
STyLUX® is ideal for the clarification and cold sterilization of
beverages, including:
•Absolute ratings of 0.04, 0.1, 0.2, 0.4 and 0.6 μm
•Highly porous asymmetric membrane
•Mineral water
•Wine and wine coolers
•Soft drinks
•Draft beer
•Extremely high flow rates at low pressure drops
•Permanently hydrophilic membrane
•Integrity testable in water
The wide chemical resistance of PES and PP makes the
STyLUX® filter perfectly suited for the purification of chemicals
such as:
•Contains no binders, adhesives or other extraneous materials
•High thermal and hydrolytic stability
•Acids & bases
•Alcohols
•Aldehydes
•Resistant to oxidizing agents
•Rugged, thermally bonded construction
•Biologically inert and non-toxic
STyLUX® is designed for the removal of particulates, colloids
and microorganisms from a broad variety of pharmaceutical
and biological solutions, including:
•High protein transmission
•100% integrity tested during manufacture
Typical Applications
STyLUX®meets the critical demand for contamination control in
the chemical, microelectronics, aerospace, food and beverage,
biologicals, veterinary, pharmaceutical and other industries.
STyLUX®may be used as either a prefilter or final filter. It offers
the greatest security for bulk and point-of-use filtration.
STyLUX® provides high quality filtration for a variety of ultrapure
water requirements, including:
•Deionized water
•High temperature water
•Chemically treated water
•Serum & blood-based products
•Tissue culture media
•Microbiological growth media
•Ophthalmics
•Oral and topical medications
•Diagnostics
•Protein solutions
•Antibiotics
•Vaccine preparations
0.04 µm
0.1 µm
0.2 µm
0.4 µm
0.6 µm
InitialDifferentialPressure,psid
Product Specifications
Materials of Construction
Filter Media: Polyethersulfone (PES)
Upstream Support: Polypropylene (PP)
Downstream Support: Polypropylene
Core/Outer Guard: Polypropylene
End Caps: Polypropylene
Sealing Method: Thermal Bonding
O-ring/Gasket Seal: Buna, EPR, polyethylene, silicone,
Teflon®over silicone, Teflon®over Viton®
All materials of construction listed above are FDA approved
for food contact use per 21 CFR 177. Filters comply with
European Commission Directive 2002/72/EC and subsequent
amendments up to Commission Regulation (EU) no 10/2011.
STyLUX®filters are manufactured in conformance to cGMP.
STyLUX®filters meet the requirements as specified in the
current USP Class VI plastics, physicochemical, oxidizable
substances, and cytotoxicity tests. Bacterial endotoxin levels
in aqueous extracts of STyLUX® filters are less than 0.5 EU/
mL, as determined using the Limulus amebocyte lysate (LAL)
test. No binders, adhesives or surfactants are used in the
construction of STyLUX® filters. STyLUX® filters are non-fiber-
releasing as defined in 21 CFR 210.3(b)(6) and211.72.
Filtration Ratings
Filter Grade: Absolute Ratings (µm):
SM, ST, SL 0.04, 0.1, 0.2, 0.4, 0.6
SP 0.04, 0.1, 0.2, 0.4
SC 0.1
Integrity Testing
Minimum Bubble Point, Water
Bacterial Retention
ASTM F838-05 Challenge:
SM/ST
0.04 μm, 0.1 μm, 0.2 μm > 107 cfu/cm2 Brevundimonas
diminuta and meet the FDA definition of a sterilizing grade filter.
0.04 μm > 107 cfu/cm2Acholeplasma laidlawii
0.1 μm ≥ 104cfu/cm2Acholeplasma laidlawii
0.4 μm > 107 cfu/cm2Serratia marcescens
0.6 μm > 107 cfu/cm2Saccharomyces cerevisiae
SC
0.1 μm > 107 cfu/cm2Brevundimonas diminuta and meets the
FDA definition of a sterilizing grade filter.
0.1 μm > 107 cfu/cm2Acholeplasma laidlawii
Sterilization
Steam-in-place (SIP):
saturated steam @ 121-135 ˚C, 30-60 minutes[15 psi (1 bar) to 30 psi (2 bar), 30-60 minutes]
Autoclave: 121-135 ˚C, 30-60 minutes
STyLUX®cartridges are capable of repeated sterilization cycles
without loss of integrity. For applications requiring autoclave/
SIP, a stainless steel reinforcement ring must be ordered.
See “Reinforcement Ring Option” on back page. (Membrane
must be wet prior to steam sterilization. Reference “Green
Docs” online for more information.)
Maximum Operating Temperatures and Pressures
Δp 80 psi @ 32 °F to 100 °F
(Δp 5,5 bar @ 0 °C to 38°C)
Δp 60 psi @ 150 °F
(Δp 4,1 bar @ 66 °C)
Δp 30 psi @ 180 °F
(Δp 2,1 bar @ 82 °C)
Typical Water Flow Rates per 10" Cartridge
L min-1
0 5 10 15 20 25 30 35
Cartridge Dimensions (nominal)
Diameter: 2.75" (7 cm) 8
Lengths: 10", 20", 30", 40" 7
(25 cm, 50 cm, 75 cm, 100 cm)6
5
4
600
500
400
300
3 200
2
100
1
0 0
0 1 2 3 4 5 6 7 8 9 10
Flow Rate, gpm
∆p(mbar)
SM/ST0.04 µm 115 psi (7,9 bar)
0.1 µm
0.2 µm
0.4 µm
0.6 µm
80 psi
44 psi
32 psi
18 psi
(5,5 bar)
(3,0 bar)
(2,2 bar)
(1,2 bar)
SC
0.1 µm 110 psi (7,6 bar) 10
9
-226 O-ring -222 O-ring -226 nO-Ring® -222 nO-Ring®
STyLUX® Filter Cartridge
End Cap Configuration
External -226 O-rings withlocking tabs; open end forC6
and F6 SOE configurations
External -222 O-rings;openend for C2 and F2 SOE
configurations
External -226 nO-Ring® withlocking tabs; open end forC5
and F5 SOE configurations
External -222 nO-Ring®, openend for C1 and F1 SOE
configurations
Flat Gasket Internal O-ring Button Cap Alignment Fin Recessed Cap
Flat Gasket; open end forGS
and GL DOE configurations
Internal O-ring; open end for
DN and DA DOE or RN andRA SOEconfigurations
Button Cap; closed end for
C1, C2, C5 and C6 SOE
configurations
Alignment Fin; closed end for
F1, F2, F5 and F6 SOE
configurations
Recessed Cap; closed end for
RN and RA SOE configurations
Ordering Information
DOE = Double Open End
SOE = Single Open End
FilterGrade
AbsoluteRating (μm)
CartridgeLength
End CapConfiguration
ReinforcementRing Option
Seal Material(O-ring or Gasket)
SM 0.2 3 F2 R S
O-ring Seal
B = Buna
E = EPR
S = Silicone
T = Teflon®over silicone
V = Viton®
X = Teflon®over Viton®
Gasket Seal
B = Buna
E = EPR
P = Polyethylene
S = Silicone
T = Teflon®
V = Viton®
Grade Descriptions
SM = This sterilizing grade filter is absolute, microbially rated and 100% integrity tested and flushed with DI water during manufacture. It is suited for critical applications whenregulatory documentation requirements are minimal. A Certificate of Conformance is provided.
ST = This sterilizing grade, absolute microbially rated filter meets full traceability requirements for the pharmaceutical industry. It is 100% integrity tested and flushed with DI waterduring manufacture. Each ST grade filter is shipped with a Certificate of Quality that gives precise information on the quality, integrity and acceptance criteria of the filter. This is avalidatable product to meet the stringent requirements of the pharmaceutical industry.
SC0.1 = This is a sterilizing grade filter designed specifically for the 100% removal of Mycoplasma. It is 100% integrity tested and DI flushed during manufacture and it has the addedbenefit of certification that meets the critical needs of the pharmaceutical, biotechnology and related industries. Each SC0.1 filter comes with a Certificate of Quality that gives preciseinformation on the quality, integrity and acceptance criteria of the filter.
SL = This filter is not 100% integrity tested or flushed with DI water during manufacture. It is offered as an economicalprefilter or final filter when sterility assurance and validation are not required. A Certificate of Conformance is provided.
SP = This is an absolute, particulate rated filter. It is 100% integrity tested and DI flushed during manufacture.A Certificate of Conformance is provided.
SM 0.04, 0.1, 0.2, 1 = 10" GS = DOE; flat gaskets (Blank) = Standard -
0.4, 0.6 (25 cm) (9.75", 19.5", 29.25", 39" length filters) no reinforcement ring
2 = 20" GL = DOE; flat gaskets
ST 0.04, 0.1, 0.2, (50 cm) (20", 30", 40" length filters) R = Reinforcement ring;
0.4, 0.6 3 = 30"
(75 cm)
C1
C2
=
=
SOE; -222 nO-Ring®, button cap end
SOE; -222 O-rings, button cap end
required for autoclave/
SIP applications
SC 0.1 4 = 40" F1 = SOE; -222 nO-Ring®, fin end
SL 0.04, 0.1, 0.2,(100 cm)
F2 = SOE; -222 O-rings, fin end
0.4, 0.6 C5 = SOE; -226 nO-Ring®, button cap end
C6 = SOE; -226 O-rings, button cap end
SP 0.04, 0.1, F5 = SOE; -226 nO-Ring®, fin end
0.2, 0.4 F6 = SOE; -226 O-rings, fin end
DN = DOE; internal -120 O-rings
RN = SOE; internal -120 O-rings,
recessed cap end
DA = DOE; internal -213 O-rings
RA = SOE; internal -213 O-rings,
recessed cap end
Steridyne®Filter Cartridge
Steridyne® f il ter cart ridges are hydrophobic, pleated, 0.2 µm absolute-rated PVDF membrane fil ters. In air andgas streams, they are virus retent ive and wil l remove contaminants to 0.01 µm. Offering high flow rates andbroad chemical compat ibil ity, the Steridyne® f il ter is ideal for the removal of part icles and microorganismsfrom gases in the pharmaceut ical, biologicals, chemical, and food and beverage industries. It is opt im ized forsterile tank vent ing, fermentat ion air and compressed air and gas f iltrat ion applicat ions.
The Steridyne® f il ter can also be used to fil ter many low surface tension chemicals and solvents.It is a sterilizing grade filter, based on ASTM F838-05 liquid bacterial challenge test ing.
The Steridyne® PVDF filter membrane is manufactured by Meissner ’s state-of -the-art process.All f il ter support components are polypropylene. Through a unique process, the membraneand polypropylenesupport componentsarethermally bonded to thecartridgeend caps.This produces an integral f il ter cart ridge with excellent mechanical st rength, wide chemicalcompat ibility and minimal extractables.
The Steridyne® f il ter ’s PVDF membrane is made without wet t ing agents, post treatmentsor other added materials. Steridyne® f iltersarecert if ied asnon-f iber-releasing. EachSteridyne® f il ter car t ridge is 100%integrity tested during manufacture. Each lot is tested forbacterial retent ion, according to ASTM methodology.
Fe a ture s a nd Be ne fits
• Inert , rugged PVDF membrane and polypropylenecomponentsof fer widechemical compat ibili tyand thermal strength in abroad rangeof f luidsand applicat ions
• Absolute 0.2 µm rated fil ter meets steril iz ing gradefil ter criteria per ASTM F838-05 methodology andis virus retent ive in air and gas applicat ions
Typical Applications
Steridyne®meets theneed for crit ical contaminat ioncontrol in the pharmaceut ical, biologicals,biopharmaceut ical, bioprocessing, microelect ronics,chemical, food and beverage and other processindustries. It wil l remove part icles and microorganismsfrom awiderangeof process fluids. Typicalair and gasapplicat ions include:
• Contains no binders or adhesives for wide solventcompat ibili tywith extremely low extractables
• 100%integrity tested during manufacture to ensureproduct integrity, consistency and reliability
• Integrity testable for assured product integrity and
• Sterile tank vent ing
• Process gases
• Compressed air
• Fermentor inlet air and
off-gases
• Nitrogen and other
inert gases
• Bioreactor inlet and
out let air
ef fect iveness in operat ion
• Biologically iner t and non-tox ic, the fil ter meets FDArequirements for food contact useand passesUSPClass VI Plast ics biological react ivity tests
Steridyne® wets immediately in compat ible non-aqueousliquids. In aqueous liquids, the Steridyne® f il ter must bepre-wet by immersion in a low surface tension liquid(<35 dynes/ cm). Typical liquid applicat ions include:*
• Filters comply with European Commission Directive2002/ 72/ ECand subsequent amendments upto 2008/ 39/ EC
• Acids
• Alcohols
• Ant ibiot ic andsolvent mix tures
• Solvents
• Weak bases
* Not recomm ended for concent rated chlorinated hydrocarbon andketonesolut ions. Consult Meissner for chemical compat ibil it y.
Steridyne® SEM
0.2 µm
Product Specif icat ions
Materials of Construction
Filter Membrane: Polyvinylidene Fluoride (PVDF)
Upstream Support : Polypropylene
Downstream Support : Polypropylene
Core/ Outer Guard: Polypropylene
End Caps: Polypropylene
Sealing Method: Thermal Bonding
O-ring/ Gasket Seal: Buna, EPR, polyethylene, sil icone,Teflon® over silicone, Teflon® over Viton®
All materialsof construct ion listed aboveareFDAapproved for food contact use per 21 CFR 177.Fil ters comply with European Commission Directive2002/ 72/ ECand subsequent amendments upto 2008/ 39/ EC.
Steridyne® f il ters are manufactured in conformancetocGMP. Steridyne® f iltersmeet the requirementsas specif ied in the current USPClass VI plast ics,physicochemical, ox idizable substances, andcytotox icity tests. Bacterial endotox in levels inaqueous extracts of Steridyne® f il ters are less than0.5 EU/ mL, as determined using the Limulusamebocyte lysate (LAL)test . No binders, adhesivesorsurfactants are used in the construct ion of Steridyne®
f ilters. Steridyne® f ilters are non-f iber-releasing asdef ined in 21 CFR210.3(b)(6) and 211.72.
Filtration Rating (Absolute)
0.2 µm
Integrity Testing
Minimum Bubble Point , 60%IPA18 psi (1,2 bar)
Cartridge Dimensions (nominal)
Diameter: 2.75" (7 cm)Lengths: 10", 20", 30", 40"(25 cm, 50 cm, 75 cm, 100 cm)
Bacterial Retention
Steridyne® retains >107cfu/ cm2Brevundimonas
diminuta, qualifying it as a steril iz ing grade filter, perASTM F838-05 liquid challenge methodology.
Sterilization
Steam-in-place (SIP):saturated steam @121-135 °C, 30-60 minutes[15 psi (1 bar) to 30 psi (2 bar), 30-60 minutes]
Autoclave: 121-135 °C, 30-60 minutes
Steridyne®cartridges arecapable of repeatedsterilizat ion cycles without loss of integrity. Forapplicat ions requiring autoclave/ SIP, a stainlesssteel reinforcement ring must be ordered. See“Reinforcement Ring Opt ion” in Ordering Informat ion.
Maximum Operating Temperatures and Pressures
∆p 80 psi @32 °F to 100 °F(∆p 5,5 bar @0 °C to 38 °C)
∆p 60 psi @ 150 °F(∆p 4,1 bar @ 66 °C)
∆p 30 psi @ 180 °F(∆p 2,1 bar @ 82 °C)
Typic a l Wa te r Flo w Ra te s pe r 10" C a rtridg e
L m in- 1
0 10 20 306
5
4
3
2
1
0
400
350
300
250
200
150
100
50
0
2.0
1.8
1.6
1.4
1.2
1.0
0.8
0.6
0.4
0.2
0
Typic a l Air Flo w Ra te s pe r 10" C a rtridg e
Nm 3 hr- 1
0 20 40 60 80 100
0.2 µm
120
100
80
60
40
20
0
0 1 2 3 4 5 6 7 8 9 10
Flo w Ra te , g pm
0 10 20 30 40 50 60
Flo w Ra te , sc fm
∆p
(mb
ar)
Init
ial
Dif
fere
nti
al
Pre
ssu
re,
psid
∆p
(mb
ar)
Init
ial
Dif
fere
nti
al
Pre
ssu
re,
psid
- 226 O- ring - 222 O- ring - 226 nO- Ring - 222 nO- Ring
Steridyne®Filter Cartridge
End Cap Conf igurat ion
External -226 O-rings with
locking tabs; open end for C6and F6 SOE configurations
External -222 O-rings; open
end for C2 and F2 SOEconfigurations
External -226 nO-Ring® with
locking tabs; open end for C5and F5 SOE configurations
External -222 nO-Ring®, open
end for C1 and F1 SOEconfigurations
Flat Gaske t Inte rnal O- ring Butto n C a p Alig nm e nt Fin Re c e sse d Cap
Flat Gasket; open end for GS
and GL DOE configurations
Internal O-ring; open end for
DN and DA DOE or RN and
RA SOE configurations
Button Cap; closed end for
C1, C2, C5 and C6 SOE
configurations
Alignment Fin; closed end for
F1, F2, F5 and F6 SOE
configurations
Recessed Cap; closed end for
RN and RA SOE configurations
Ordering Information
DOE = Double Open EndSOE = Single Open End
FilterGrade
AbsoluteRating (μm)
CartridgeLength
End CapC o nfig ura tio n
ReinforcementRing Option
Seal Material(O-ring or Gasket)
VMV 0.2 - 3 F2 R S
VMV
VTV
0.2
0.2
1 = 10"
(25 cm)
2 = 20"
(50 cm)
3 = 30"
(75 cm)
4 = 40"
GS = DOE; flat gaskets
(9.75", 19.5", 29.25", 39" length filters)
GL = DOE; flat gaskets
(20", 30", 40" length fil ters)
C1 = SOE; -222 nO-Ring®, but ton cap end
C2 = SOE; -222 O-rings, but ton cap end
F1 = SOE; -222 nO-Ring®, f in end
(Blank) = Standard - no
reinforcement ring
R = Reinforcement ring;
required for autoclave/
SIP applicat ions
O-ring Seal
B = Buna
E = EPR
S = Silicone
T = Teflon® over sil icone
V = Viton®
X = Teflon® over Viton®
l
Grade Descriptions
VMV = This ster i l izing grade fi l t er is abso lute, microb ial ly rated and 100%in tegr it y tested dur ing manufactu re. It is su ited for cr i t ical app licat ions when regu lato ry document at ion requ irement s areminimal. A Cert if icate of Conformance is available on a lot basis.
VTV = Th is abso lute, microb ial ly rated , ster i l izing grade fi l t er meet s fu l l t raceab i l i t y requ irem ent s fo r the pharmaceut ical indust ry. It is 100%in tegr it y tested dur ing manufactu re. Each VTV grade fi l t er issh ipped with a Cer t i f icate of Qual i t y stat ing exact qual i t y con t rol cri t er ia and test per fo rm ance resu lt s. This is a val idatab le product to meet the st r ingent requ irement s of the pharmaceut ical indust ry.
(100 cm) F2 = SOE; -222 O-rings, f in end
C5 = SOE; -226 nO-Ring®, but ton cap end Gasket Sea
C6 = SOE; -226 O-rings, but ton cap end B = Buna
F5 = SOE; -226 nO-Ring®, fin end E = EPR
F6 = SOE; -226 O-rings, f in end P = Polyethylene
DN = DOE; internal -120 O-rings S = Silicone
RN = SOE; internal -120 O-rings, T = Teflon®
DA =
recessed cap end
DOE; internal -213 O-rings
V = Viton®
RA = SOE; internal -213 O-rings,
recessed cap end
Chemdyne®Filter Cartridge
The Chemdyne® filter cartridge is an absolute rated, pleated membrane filter that is
constructed of 100% pure polypropylene. It provides maximum chemical compatibility,
performance and economy while controlling contaminants in critical processes.
Its pure polypropylene membrane is made by a patented process, which produces a
highly porous structure that is inherently hydrophobic. This uniform structure
maintains consistent porosity and particle retention throughout its operational life,
even after repeated in-line steam sterilization or autoclaving. A unique,
state-of-the-art process thermally bonds the filter and support components to the
cartridge end caps. This produces an integral filter cartridge with excellent
chemical compatibility and exceptionally low extractables levels.
Available in absolute retention ratings of 0.04, 0.1 and 0.2 micron, the Chemdyne® filter
offers a cost effective alternative to PTFE membrane filter cartridges. Constructed entirely of inert polypropylene, the
Chemdyne® filter offers similar chemical compatibility, reliability, and performance of PTFE membrane cartridges.
Features and Benefits
• 100% polypropylene components provide wide
chemical compatibility and permit use in a broad
range of fluids and applications
• Absolute ratings of 0.04, 0.1 and 0.2 micron deliver
precise particle retention at rated level
• Unique polypropylene membrane offers high flow
rates, long service life and is a cost effective
alternative to PTFEmembranes
• Inherently hydrophobic membrane provides a natural
barrier to water without the use of additives or
surface modifying agents which can leach or wash out
• Rugged, thermally bonded construction ensures
reliable integrity under severe process conditions and
withstands multiple sterilizations
• Contains no binders or adhesives for wide solvent
compatibility with extremely low extractables
• Fully integrity testable for assurance of product
integrity and effectiveness in operation
• 100% integrity tested by factory to guarantee
product reliability and consistency
• Biologically inert and non-toxic - Chemdyne®
meets FDA requirements for food contact use and
is biosafe in compliance with USP Class VI biological
reactivity tests
Typical Applications
Chemdyne®meets the critical demand for contamination
control in the chemical, microelectronics, aerospace,
photonics, biologicals, pharmaceutical, cosmetics, and
other industries. The Chemdyne® cartridge is designed for
the removal of particulates, colloids and microorganisms
from solvents, corrosive chemicals and gases. It also
offers high security for bulk and point-of-use filtration.
Typical chemicals include:
• Acids
• Bases
• Alcohols
• Solvents
• Etchants
• Photoresists
• Photolithographic solutions
For aqueous solutions, the Chemdyne® filter must
be pre-wet by immersion in a suitable low surface
tension fluid.
The inherently hydrophobic Chemdyne® filter is ideal
for gas filtration applications which include:
• Compressed air
• Fermentation air
• Pressurized gases
• Tank ventilation
InitialDifferentialPressure,psid
Product Specifications
Materials of Construction
Filter Media: Polypropylene
Upstream Support: Polypropylene
Downstream Support: Polypropylene
Core/Outer Guard: Polypropylene
End Caps: Polypropylene
Sealing Method: Thermal bonding
O-ring/Gasket Seal: Buna, EPR,
polyethylene, silicone, Teflon® over silicone,
Viton®, Teflon® over Viton®
Filtration Ratings
Filter Grade: Absolute Ratings (µm):
PM 0.04, 0.1, 0.2
PT 0.2
Integrity Testing
Minimum Bubble Point, 60% IPA
0.04 µm 29 psi (2,0 bar)
0.1 µm 24 psi (1,7 bar)
0.2 µm 10 psi (0,7 bar)
Cartridge Dimensions (nominal)
Diameter: 2.75" (7 cm)
Lengths: 10", 20", 30", 40"
(25 cm, 50 cm, 75 cm, 100 cm)
Bacterial Retention
ASTM F838-05 Challenge
0.1 µm, 0.2 µm > 107 cfu/cm2Brevundimonas diminuta
(0.1 µm, 0.2 µm meet the FDA definition
of a liquid rated sterilizing grade filter.)
Sterilization
Steam-in-place (SIP):
saturated steam @ 121-135 ˚C, 30-60 minutes[15-30 psi (1-2 bar), 30-60 minutes]
Autoclave: 121-125 ˚C, 30-60 minutesChemdyne® cartridges are capable of repeated
sterilization cycles without loss of integrity.
For applications requiring autoclave/SIP, a
stainless steel reinforcement ring must be ordered.
See “Reinforcement Ring Option” on back page.
Maximum Operating Temperatures
and Pressures
80 psid @32°F to 100°F
(∆p 5,5 bar @ 0°C to 38°C)
60 psid @150°F
(∆p 4,1 bar @ 66°C)
30 psid @180°F
(∆p 2,1 bar @ 82°C)
Typical Water Flow Rates per 10" Cartridge
L min-1
0 5 10 15 20 25 30 35
10
9
80.04 µm
0.1 µm
7 0.2 µm
6
5
4
3
2
1
600
500
400
300
200
100
3.0
2.5
2.0
1.5
1.0
0.5
Typical Air Flow Rates per 10" Cartridge
Nm3hr-1
0 20 40 60 80 100
0.04 µm
0.1 µm
0.2 µm
200
150
100
50
0 0
0 1 2 3 4 5 6 7 8 9 10
Flow Rate, gpm
0.0 0
0 10 20 30 40 50 60
Flow Rate, scfm
∆p(mbar)
∆p(mbar)
InitialDifferentialPressure,psid
Chemdyne®Filter Cartridge
End Cap Configuration
-226 O-ring -222 O-ring -226 nO-Ring -222 nO-Ring
External -226 O-rings with
locking tabs; open end forC6and F6 SOE configurations
External -222 O-rings;open
end for C2 and F2 SOEconfigurations
External -226 nO-Ring®with
locking tabs; open end forC5and F5 SOE configurations
External -222 nO-Ring®, open
end for C1 and F1 SOEconfigurations
Flat Gasket Internal O-ring Button Cap Alignment Fin Recessed Cap
Flat Gasket; open end forGS
and GL DOE configurations
Internal O-ring; open end for
DN and DA DOE or RN and
RA SOEconfigurations
Button Cap; closed end for
C1, C2, C5 and C6 SOE
configurations
Alignment Fin; closed end for
F1, F2, F5 and F6 SOE
configurations
Recessed Cap; closed end for
RN and RA SOE configurations
Ordering InformationDOE = Double Open End
SOE = Single Open End
FilterGrade
AbsoluteRating (µm)
CartridgeLength
End CapConfiguration
ReinforcementRing Option
Seal Material(O-ring or Gasket)
PM 0.2 - 3 F2 R S
1 = 10"
(25 cm)
2 = 20"
(50 cm)
3 = 30"
(75 cm)
4 = 40"
(100 cm)
GS = DOE; flat gaskets
(9.75", 19.5", 29.25", 39" lengthfilters)
GL = DOE; flat gaskets
(20", 30", 40" length filters)
C1 = SOE; -222 nO-Ring®, button cap end
C2 = SOE; -222 O-rings, button cap end
F1 = SOE; -222 nO-Ring®, fin end
F2 = SOE; -222 O-rings, fin end
(Blank) = Standard -
no reinforcement ring
R = Reinforcement
ring; required for
autoclave/SIP
applications
O-ring Seal
B= Buna
E= EPR
S= Silicone
T= Teflon ® over Silicone
V= Viton ®
X= Teflon ® over Viton®
C5 = SOE; -226 nO-Ring®, button cap end Gasket Seal
F5 = SOE; -226 nO-Ring®, fin end B= Buna
C6 = SOE; -226 O-rings, button cap end
F6 = SOE; -226 O-rings, fin end
DN = DOE; internal -120 O-rings
RN = SOE; internal -120 O-rings,
recessed cap end
DA = DOE; internal -213 O-rings
RA = SOE; internal -213 O-rings,
recessed cap end
E= EPR
P= Polyethylene
S= Silicone
T= Teflon ®
V= Viton ®
Grade Descriptions
PM = This sterilizing grade filter is absolute, microbially rated and 100% integrity tested during manufacture. It is suited for critical applications when regulatory documentation
requirements are minimal. A Certificate of Conformance is available on a lot basis.
PT = This absolute, microbially rated, sterilizing grade filter meets full traceability requirements for the pharmaceutical industry. It is 100% integrity tested during manufacture.
Each PT grade filter is shipped with a Certificate of Quality stating exact quality control criteria and test performance results. This is a validatable product to meet the stringent
requirements of the pharmaceutical industry.
Viton and Teflon are registered trademarks of DuPont Dow Elastomers L.L.C. & The DuPont Company
© 2008, 2000, 1995 Meissner Filtration Products, Inc.
PM 0.04, 0.1, 0.2
PT 0.2
Protec® Filter Cartridge
The Protec® f i lter is a glass microf iber pref i lter optimized
to protect downstream sterile f ilters. The Protec®RF f i lter
contains a single layer of borosilicate glass f iber media in a
choice of absolute-rated 0.5 µm or 1 µm. The Protec®RM f i lter
is available in a choice of absolute-rated 0.2 µm, 0.3 µm or
0.5 µm and combines an outer layer of borosilicate glass f iber
media with an inner layer of Meissner’s proprietary hydrophilic
SteriLUX®PVDF membrane.
Protec® f i lters provide consistent submicron contaminant
removal, high dirt-holding capacity and high f low rates, while
removing colloids, aggregated and non-product proteins, lipids
and other particles. Protec®effectively protects downstream
membrane f ilters and equipment. These f i lter cartridges are
available in lengths of 10, 20, 30 and 40 inches.
Features and Benefits
•RF version can be specif ied in 0.5 µm and 1 µm
absolute-rated
•RM version can be specif ied in absolute-rated
0.2 µm, 0.3 µm and 0.5 µm
•High f low rates and excellent f i ltration economics
•High contaminant holding capacity provides a long
service life
•All-polypropylene support materials provide wide
chemical compatibility and permit use in a broad
range of f luids
•Protec®RM combines the retention performance
of a PVDF membrane with the high adsorption and
contaminant-holding capacity of a glass f iber media
Typical Applications
Protec® f ilters are ideal for clarif ication, pref iltration
and bioburden reduction in a variety of applications.
•Biological liquids, including serum, plasma fractions
and other blood products
•Vaccines
•Tissue and cell culture media
•Protein solutions
•Fermentation media and feeds
•Cell removal from fermentation broths
•Pre-column chromatography
•Biopharmaceuticals
Product Specif ications
Materials of Construction
Filter Media
RF (single layer): Borosilicate glass microf iber
RM (double layer): Borosilicate glass microfiber
with SteriLUX®PVDF membrane
Core/Outer Guard: Polypropylene
End Caps: Polypropylene
Sealing Method: Thermal Bonding
O-ring/Gasket Seal: Buna, EPR, polyethylene, silicone,
Tef lon®over silicone, Teflon®over Viton®
All materials of construction listed above are FDA approved
for food contact use per 21 CFR 177.
Protec® f i lters are manufactured in conformance to cGMP.
Protec® f i lters meet the requirements as specif ied in the
current USP Class VI plastics, physicochemical, oxidizable
substances, and cytotoxicity tests. Protec® f ilters are non-
f iber-releasing as def ined in 21 CFR 210.3(b)(6) and 211.72.
Filtration Ratings
Filter Grade Absolute Particulate Ratings
RF 0.5 µm, 1 µm
RM 0.2 µm, 0.3 µm, 0.5 µm
Cartridge Dimensions (nominal)
Diameter: 2.75" (7 cm)
Lengths: 10", 20", 30", 40"
(25 cm, 50 cm, 75 cm, 100 cm)
Typical Microbial Retention per cm2
Grade Rating Organism LRV
RF 0.5 µm Saccharomyces cerevisiae 6
RM 0.5 µm Serratia marcescens 5
Saccharomyces cerevisiae ≥7
RM 0.3 µm Serratia marcescens 6
RM 0.2 µm Serratia marcescens ≥7
Sterilization
Steam-in-place (SIP):
Saturated steam @ 121-135 ˚C, 30-60 minutes
[15 psi (1 bar) to 30 psi (2 bar), 30-60 minutes]
Autoclave: 121-135 ˚C, 30-60 minutes
For applications requiring autoclave/SIP, a stainless steel
reinforcement ring must be ordered. See “Reinforcement
Ring Option” within Ordering Information.
Maximum Operating Temperatures & Pressures
∆p 80 psi @ 32 °F to 100°F
(∆p 5,5 bar @ 0 °C to 38 °C)
∆p 60 psi @ 150 °F
(∆p 4,1 bar @ 66 °C)
∆p 30 psi @ 180 °F
(∆p 2,1 bar @ 82 °C)
Typical Water Flow Rates per 10" Cartridge
L min-1
3.0
0 10 20 30
RM 0.2 µm
200
2.5
2.0
RM 0.3 µm
RM 0.5 µm
RF 0.5 µm
RF 1 µm
150
1.5 100
1.0
50
0.5
0.0 0
0 1 2 3 4 5 6 7 8 9 10
Flow Rate, gpm
InitialDifferentialPressure,psid
∆p(mbar)
-226 O-ring -222 O-ring -226 nO-Ring® -222 nO-Ring®
Protec® Filter Cartridge
End Cap Conf iguration
External -226 O-rings with
locking tabs; open end forC6and F6 SOE configurations
External -222 O-rings;open
end for C2 and F2 SOEconfigurations
External -226 nO-Ring® with
locking tabs; open end forC5and F5 SOE configurations
External -222 nO-Ring®, open
end for C1 and F1 SOEconfigurations
Flat Gasket Internal O-ring Button Cap Alignment Fin Recessed Cap
Flat Gasket; open end forGS
and GL DOE configurations
Internal O-ring; open end for
DN and DA DOE or RN and
RA SOEconfigurations
Button Cap; closed endfor
C1, C2, C5 and C6 SOE
configurations
Alignment Fin; closed end for
F1, F2, F5 and F6 SOE
configurations
Recessed Cap; closed end for
RN and RA SOE configurations
DOE = Double Open End
SOE = Single Open End
Ordering Information
FilterGrade
AbsoluteRating (μm)
CartridgeLength
End CapConfiguration
ReinforcementRing Option
Seal Material(O-ring or Gasket)
RM 0.2 3 F2 R S
RF = Borosilicate
glass microf iber media
(single layer)
RM = Borosilicate
glass microf iber media
(outer layer) combined
with a hydrophilic
PVDF membrane
(inner layer)
0.5, 1
0.2, 0.3, 0.5
1 = 10"
(25 cm)
2 = 20"
(50 cm)
3 = 30"
(75 cm)
4 = 40"
(100 cm)
GS = DOE; f lat gaskets
(9.75", 19.5", 29.25", 39" length f ilters)
GL = DOE; f lat gaskets
(20", 30", 40" length f i lters)
C1 = SOE; -222 nO-Ring®, button cap end
C2 = SOE; -222 O-rings, button cap end
F1 = SOE; -222 nO-Ring®, f in end
F2 = SOE; -222 O-rings, f in end
C5 = SOE; -226 nO-Ring®, button cap end
C6 = SOE; -226 O-rings, button cap end
F5 = SOE; -226 nO-Ring®, f in end
F6 = SOE; -226 O-rings, f in end
DN = DOE; internal -120 O-rings
RN = SOE; internal -120 O-ring,
recessed cap end
DA = DOE; internal -213 O-rings
RA = SOE; internal -213 O-ring,
recessed cap end
(Blank) = Standard - no
reinforcement ring
R = Reinforcement ring;
required for autoclave/
SIP applications
O-ring Seal
B = Buna
E = EPR
S = Silicone
T = Tef lon®over silicone
V = Viton®
X = Tef lon®over Viton®
Gasket Seal
B = Buna
E = EPR
P = Polyethylene
S = Silicone
T = Tef lon®
V = Viton®
ALpHA® Filter Cartridge
ALpHA® f ilter cartridges are absolute rated, pleated depth-type f i lters that are constructed of 100% polypropylene. ALpHA®
cartridges are high contaminant capacity f i lters that are available in absolute particle retention ratings from 0.45 to 70 micron.
The ALpHA® f ilter’s polypropylene media is made from a process which produces a self-bonded structure comprised of multiple
layers of successively f iner f ibers and smaller pores. This unique
construction results in a highly porous, tapered pore structure
with a controlled, absolute rated inner layer and several outer
pref i lter layers to substantially increase dirt holding capacity.
This f i lter matrix of decreasing pore size and remarkably high
void volume provides superior f low rates at low pressure drops
and high throughputs, while achieving submicron retentions,
high eff iciencies and extraordinary dirt holding capacities.
All components of the ALpHA® f i lter cartridge use FDA approved
polypropylene. By a unique, state-of-the-art process, the f i lter
media and its support structure are thermally bonded to the
end caps. This provides an integral f ilter cartridge, which has
excellent chemical compatibility and minimum extractables in a
wide range of f luids and applications. ALpHA® f i lter cartridges are
offered in a range of lengths and styles to allow service in most
standard f i lter housings.
Meissner Technical Services (MTS) provides clients with completetechnical and validation support for its manufactured products.
Features
•All-polypropylene construction
•Particle removal ratings from 0.45 to 70 µm
•Self-bonded f i lter media
•Tapered pore structure delivers high dirt
holding capacity
•Contains no binders, adhesives or surfactants
•Biologically inert and non-toxic
Benef its
Wide chemical compatibility for use in a broad range of f luids
Greater selection of optimum f ilter media for precise particle retention at
desired rating
Fixed pore structure, consistent particle removal, no migration of f i lter
media, non f iber releasing
Long f ilter service life, large throughputs, lower operating costs
Wide solvent compatibility, extremely low extractables, quickly rinses
to 18 meg-ohm
Meets FDA requirements for food contact and complies with European
Commission Directives; passes USP Class VI biological tests for plastics
Typical Applications
ALpHA®polypropylene f ilter cartridges are ideal for applications where high quality f i ltration and economy are important. They may
be used as either pref i lters or as f inal f i lters. For selected applications, they are a low cost alternative to membrane f ilter cartridges.
•Water Purif ication
•Chemicals
•Solvents
•Biologicals
•Pharmaceuticals
•Ophthalmics
•Cosmetics
•Diagnostics
•Serum Products
•Food and Beverage
•Syrups
•Microelectronics
•Photonics
•Coatings
•Printing
•Metal Finishing
•Photovoltaics/Solar
•Petrochemicals
•Oil Well Production
•Compressed Air and Gasses
ALpHA®SEM
0.45 µm0.6 µm0.8 µm1.2 µm2.4 µm5 µm7 µm10 µm20 µm30 µm40 µm
Product Specif ications
Materials of Construction
Filter Media: Polypropylene
Upstream Support: Polypropylene
Downstream Support: Polypropylene
Core/Outer Guard: Polypropylene
End Caps: Polypropylene
Sealing Method: Thermal Bonding
O-ring/Gasket Seal: Buna, EPR, polyethylene,
silicone, Tef lon®over silicone,
Tef lon®over Viton®
All materials of construction listed above are FDA
approved for food contact use per 21 CFR 177. Filters
comply with European Commission Directive
2002/72/EC and subsequent amendments up to
Commission Regulation (EU) No. 10/2011.
ALpHA® f ilters are manufactured in conformance
to cGMP. ALpHA® f i lters meet the requirements
as specif ied in the current USP Class VI plastics,
physicochemical, oxidizable substances, and
cytotoxicity tests. Bacterial endotoxin levels in
aqueous extracts of ALpHA® f i lters are less than
0.5 EU/mL, as determined using the Limulus
amebocyte lysate (LAL) test. No binders, adhesives
or surfactants are used in the construction of ALpHA®
f i lters. ALpHA® f i lters are non-f iber-releasing as
def ined in 21 CFR 210.3(b)(6) and 211.72.
Filtration Ratings
Absolute Pore Sizes (µm):
0.45, 0.6, 0.8, 1.2, 2.4, 5, 7,10, 20, 30, 40, 70
Cartridge Dimensions (nominal)
Diameter: 2.75" (7 cm)
Lengths: 10", 20", 30", 40"
(25 cm, 50 cm, 75 cm, 100 cm)
Sterilization
Steam-in-place (SIP):
Saturated steam @ 121-135 ˚C, 30-60 minutes[15 psi (1 bar) to 30 psi (2 bar), 30-60 minutes]
Autoclave: 121-135 ˚C, 30-60 minutes
ALpHA®cartridges are capable of repeated sterilization
cycles without loss of integrity. For applications requiring
autoclave/SIP, a stainless steel reinforcement ring must be
ordered. See “Reinforcement Ring Option” on back page.
Maximum Operating Temperatures & Pressures
∆p 80 psi @ 32 °F to 100°F
(∆p 5,5 bar @ 0 °C to 38 °C)
∆p 60 psi @ 150 °F
(∆p 4,1 bar @ 66 °C)
∆p 30 psi @ 180 °F
(∆p 2,1 bar @ 82 °C)
The removal ratings given in the chart represent actual dynamic measurementsobtained from controlled laboratory tests using latex spheres in DI water at a flowrate of 2 gpm/10-inch element. The particle retention efficiencies were determinedusing a particle counter that accurately measured particles down to 0.3 µm.
Pore
Size
(µm)
Removal Rating in
Microns (µm) at % Efficiency
100% 99% 90%
0.45 0.45 0.40 < 0.30
0.6 0.6 0.56 0.38
0.8 0.8 0.72 0.50
1.2 1.2 1.1 0.7
2.4 2.4 2.3 2.0
5 5 4.5 3.0
7 7 6.5 5.0
10 10 9.5 7.5
20 20 19.0 12.0
30 30 26.0 16.0
40 40 35.0 28.0
Typical Water Flow Rates per 10" Cartridge
L min -1
1.4
1.3
1.2
1.1
1.0
0.9
0.8
0.7
0.6
0.5
0.4
0.3
0.2
0.1
0.0
0 5 10 15 20 25 30 35
90
80
70
60
50
40
30
20
10
0
0 1 2 3 4 5 6 7 8 9 10
Flow Rate, gpm
∆p(mbar)
InitialDifferentialPressure,psid
-226 O-ring -222 O-ring -226 nO-Ring® -222 nO-Ring®
ALpHA® Filter Cartridge
End Cap Conf iguration
External -226 O-rings with
locking tabs; open end forC6
and F6 SOE configurations
External -222 O-rings;open
end for C2 and F2 SOE
configurations
External -226 nO-Ring® with
locking tabs; open end forC5
and F5 SOE configurations
External -222 nO-Ring®, open
end for C1 and F1 SOE
configurations
Flat Gasket Internal O-ring Button Cap Alignment Fin Recessed Cap
Flat Gasket; open end forGS
and GL DOE configurations
Internal O-ring; open end for
DN and DA DOE or RN and
RA SOEconfigurations
Button Cap; closed endfor
C1, C2, C5 and C6 SOE
configurations
Alignment Fin; closed end for
F1, F2, F5 and F6 SOE
configurations
Recessed Cap; closed end for
RN and RA SOE configurations
Ordering Information
DOE = Double Open EndSOE = Single Open End
FilterMedia
AbsoluteRating (μm)
CartridgeLength
End CapConfiguration
ReinforcementRing Option
Seal Material(O-ring or Gasket)
MF 0.45 3 F2 R S
MF = 0.45 1 = 10" GS = DOE; flat gaskets (Blank) = Standard - no O-ring Seal
polypropylene 0.6 (25 cm) (9.75", 19.5", 29.25", 39" length f i lters) reinforcement ring B = Buna
microf iber 0.8 2 = 20" GL = DOE; flat gaskets E = EPR
1.2 (50 cm) (20", 30", 40" length f i lters) R = Reinforcement ring; S = Silicone
2.4 3 = 30" C1 = SOE; -222 nO-Ring®, button cap end required for autoclave/ T = Tef lon® over silicone
5 (75 cm) C2 = SOE; -222 O-rings, button cap end SIP applications V = Viton®
7 4 = 40" F1 = SOE; -222 nO-Ring®, f in end X = Teflon® over Viton®
10 (100 cm) F2 = SOE; -222 O-rings, fin end Gasket Seal
20 C5 = SOE; -226 nO-Ring®, button cap end B = Buna
30 C6 = SOE; -226 O-rings, button cap end E = EPR
40 F5 = SOE; -226 nO-Ring®, f in end P = Polyethylene
70 F6 = SOE; -226 O-rings, fin end S = Silicone
DN = DOE; internal -120 O-rings T = Tef lon®
RN = SOE; internal -120 O-ring,
recessed cap endV = Viton®
DA = DOE; internal -213 O-rings
RA = SOE; internal -213 O-ring,
recessed cap end