TIG APRIL 1998 VOL. 14 NO. 4
167Copyright © 1998 Elsevier Science Ltd. All rights reserved. 0168-9525/98/$19.00
BOOKS
ErratumThe cyclin family of budding yeast: abundant use of a good idea
by Brenda Andrews and Vivien Measday (Trends Genet. 14, 66–72)
Figure 2 of this Review article contained an error, so the correct version is shown here.
Cell cycle Cell metabolism
Transcription
Ccl1p–Kin28p
Srb11p–Srb10p
Ctk2p–Ctk1p
RNAPol IICTD
SBF/MBF
Clb5p/6p–Cdc28p Cln1p/2p–Cdc28p(Pcl1p/2p–Pho85p)
Sic1p
Far1pCLNs
Budding
DNAreplication
ORCCdc6pMCMs
Clb1p–4p–Cdc28p
Mitotic events
Cln3p–Cdc28p
CLB–Cdc28p
Spindle-pole-bodyduplication
Swi4pSwi5p
SFF/Mcm1p
Pheromonepathway
CLBproteolysis
Pho80p–Pho85p
Pho4p
Pcl8p/10p–Pho85p
Gsy2p
FIGURE 2. Regulatory pathways involvingyeast CDK complexes. Only those CDKcomplexes with established biologicalfunctions are shown. Cdc28p complexesare shown in yellow, Pho85p complexesin blue and other CDK complexes inpurple. Known substrates are in red textand proteins implicated as CDK targetsin vivo are in green. Black arrowsindicate activation of the target proteinby the CDK and a black bar denotesrepression. See text and Tables 1–3 fordiscussion of these and other yeast CDKs.
Correction to Table 1
Pho85p interacts with Pcl1p and Pcl2p
Correction to Table 3
Gsy2p (not Gys2p)
An ‘encyclopaedia’ is defined in theOxford English Dictionary as a workcontaining extensive and comprehensiveinformation on all branches ofknowledge. It also brings to mind thebooks you used to receive at Christmasalongside The Blue Peter Annual. Andtherein lies the problem in compiling abook of this type for rapidly advancingfields, such as molecular biology ormolecular medicine, while the FootballEncyclopedia 1997 might prove less ofa problem. The Encyclopedia ofMolecular Biology and MolecularMedicine’, however, makes an excellentattempt at living up to its title. Thesections on basic theoretical conceptsand techniques are thorough and verywell explained. Thus, linkage andtranscriptional regulation are welldescribed and the chapter onchemiluminescence is particularly good.Cross references, which are vital in anencyclopaedia, are excellent and the
index is very comprehensive. We foundit particularly useful for obtaining‘single-sentence’ definitions formoderately difficult concepts. Eachchapter commences with a series ofkeywords, which are then carefully andbriefly defined in the context of thatchapter. Depending on the angle ofattack, for example, teaching a particularcourse, several definitions could beobtained easily and an appropriate onechosen. For linkage alone there wereseven separate definitions, each slightlydifferent. The chapters are well writtenand so reading it is not a chore;however, for the majority of readers, thesix-volume nature of the book wouldpreclude it as bedtime reading.
The one area where the books fallsdown slightly is in fields where the paceof research is very rapid. This is notreally a criticism of this work, butindeed one which could, inevitably, belevelled at many textbooks. Thus,
chemokines are restricted to a definitionin the chapter on growth factors. In lightof the recent advances linkingchemokine receptors, such as CCR5,and HIV infection, it is obvious that theymerit a much more detailed treatment.The section on mRNA stability is verybrief and makes no mention of AU-richelements or of nonsense-mediatedinstability and, although the transgenicsection gives a very good overview oftransgenic and knockout technology,there is little detail provided. Specifictechniques, such as the use of theCre/Lox system to construct knockoutmice, are not mentioned at all.
As a teaching aid and as a means ofgathering background information onsubjects about which the reader knowslittle, the Encyclopedia is an excellent book and we wouldthoroughly recommend it. Mind you, if anyone wants to swap it for someBlue Peter Annuals…
Bernard J. Morley [email protected]
Tracey J. [email protected]
Rheumatology Section, Division of Medicine,Imperial College School of Medicine,
Hammersmith Site, London, UK W12 0NN.
The Full Monty
Encyclopedia of Molecular Biology and Molecular Medicine (Vols 1–6)edited by Robert A. MeyersVCH Press, 1997. £220.00 per volume (~500 pages per volume) ISBN 3 527 28471 0
We apologize to the authors for publishing an incorrect version of their article.
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