Epstein-Barr Virus
Brittany Seyler
What is it?
• Herpes virus that infects B Cells and Epithelial cells- linked to malignancies in both
• Responsible for Infectious Mononucleosis
• 2nd most common
BackgroundNamed after M. Anthony Epstein and
Yvonne Barr in 1961
Humans are the only known reservoir
TransmissionSaliva
Blood transfusions
Infects 95% of the world’s population
90% of US population infected by age 25
Symptoms •Fever
•Fatigue
•Sore throat
•Swollen lymph glands
•Weight Loss
•Vomiting
•Hemolysis
Demographics
• Occurs worldwide• No racial predilection• Occurs earlier in
females than males
Structure Crystal structure
Linear, double stranded DNA
“spikes”
Viral envelope easily damaged
Toroidal shaped core
Representation Of Immuno response vs viral incubation.
•Each Line Plot represents different antigens to the EBV over the incubation period of the virus as a whole.
•This scaling can be used in the testing of carriers, and previous carriers of the EBV
Viral Detail•Family:Herpesviridae
•Subfamily:Gammaherpesvirinae
•Genus:Lymphocryptovirus
•Species:Human herpesvirus 4 (HHV-4)
•Associated with several forms of cancer, lymphoma in HIV patients, and believed to be associated with higher risks of autoimmune conditions in those affected.
Prevention
Sources
http://www.cdc.gov/ncidod/diseases/ebv.htmhttp://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001617/http://emedicine.medscape.com/article/963894-overviewhttp://www.pnas.org/contenthttp://www.nature.com/nsmb/journalhttp://virus.stanford.edu/herpes/transmission.htmlhttp://bioweb.uwlax.edu
Thank You :)